CSH1 (chorionic somatomammotropin hormone 1)

2009-01-01  

Identity

HGNC
LOCATION
17q23.3
LOCUSID
ALIAS
CS-1,CSA,CSMT,GHB3,PL,hCS-1,hCS-A
FUSION GENES

Other Information

Locus ID:

NCBI: 1442
MIM: 150200
HGNC: 2440
Ensembl: ENSG00000136488

Variants:

dbSNP: 1442
ClinVar: 1442
TCGA: ENSG00000136488
COSMIC: CSH1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136488ENST00000316193P0DML2
ENSG00000136488ENST00000316193A8K6C2
ENSG00000136488ENST00000329882A6NFB4
ENSG00000136488ENST00000453363B1A4H2
ENSG00000136488ENST00000610991A0A087WUG6

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Jak-STAT signaling pathwayKEGGko04630
Neuroactive ligand-receptor interactionKEGGhsa04080
Jak-STAT signaling pathwayKEGGhsa04630
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Growth hormone receptor signalingREACTOMER-HSA-982772
Prolactin receptor signalingREACTOMER-HSA-1170546

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
182925252008Alternatively activated macrophages regulate extracellular levels of the hormone placental lactogen via receptor-mediated uptake and transcytosis.24
202337822010Differential expression profile of growth hormone/chorionic somatomammotropin genes in placenta of small- and large-for-gestational-age newborns.14
192908442009Effect of maternal smoking on cord blood estriol, placental lactogen, chorionic gonadotropin, FSH, LH, and cortisol.13
155315132004Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster.11
223870442012Differential placental expression profile of human Growth Hormone/Chorionic Somatomammotropin genes in pregnancies with pre-eclampsia and gestational diabetes mellitus.9
165462092006Crystal structure and site 1 binding energetics of human placental lactogen.8
169508182006Measurement of mRNA of trophoblast-specific genes in cellular and plasma components of maternal blood.6
204272832010Obligate ordered binding of human lactogenic cytokines.6
217652432011Human placental lactogen (hPL-A) activates signaling pathways linked to cell survival and improves insulin secretion in human pancreatic islets.6

Citation

Dessen P

CSH1 (chorionic somatomammotropin hormone 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-01-01

Online version: http://atlasgeneticsoncology.org/gene/50632/csh1