Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1473
MIM: 123858
HGNC: 2477
Ensembl: ENSG00000170367
Variants:
dbSNP: 1473
ClinVar: 1473
TCGA: ENSG00000170367
COSMIC: CST5
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000170367 | ENST00000304710 | P28325 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Salivary secretion | KEGG | ko04970 |
| Salivary secretion | KEGG | hsa04970 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164713366 | Tumor necrosis factor alpha (TNF-alpha) inhibitors | Chemical | ClinicalAnnotation | associated | PD | ||
| PA443434 | Arthritis, Rheumatoid | Disease | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 28694499 | 2017 | Cystatin D (CST5): An ultra-early inflammatory biomarker of traumatic brain injury. | 16 |
| 28694499 | 2017 | Cystatin D (CST5): An ultra-early inflammatory biomarker of traumatic brain injury. | 16 |
| 26158294 | 2015 | p53 directly activates cystatin D/CST5 to mediate mesenchymal-epithelial transition: a possible link to tumor suppression by vitamin D3. | 16 |
| 26364852 | 2015 | Cystatin D locates in the nucleus at sites of active transcription and modulates gene and protein expression. | 13 |
| 26158294 | 2015 | p53 directly activates cystatin D/CST5 to mediate mesenchymal-epithelial transition: a possible link to tumor suppression by vitamin D3. | 16 |
| 26364852 | 2015 | Cystatin D locates in the nucleus at sites of active transcription and modulates gene and protein expression. | 13 |
| 20223287 | 2010 | The effects of 1,25-dihydroxyvitamin D3 on colon cancer cells depend on RhoA-ROCK-p38MAPK-MSK signaling. | 10 |
| 20379614 | 2010 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | 78 |
| 20223287 | 2010 | The effects of 1,25-dihydroxyvitamin D3 on colon cancer cells depend on RhoA-ROCK-p38MAPK-MSK signaling. | 10 |
| 20379614 | 2010 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | 78 |
| 19662683 | 2009 | Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells. | 49 |
| 19662683 | 2009 | Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells. | 49 |
| 15728581 | 2005 | Crystal structure of human cystatin D, a cysteine peptidase inhibitor with restricted inhibition profile. | 14 |
| 15728581 | 2005 | Crystal structure of human cystatin D, a cysteine peptidase inhibitor with restricted inhibition profile. | 14 |
Citation
Dessen P
CST5 (cystatin D)
Atlas Genet Cytogenet Oncol Haematol. 2009-09-01
Online version: http://atlasgeneticsoncology.org/gene/51126/cst5
