Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CTNNA2 (catenin alpha 2)

Identity

Alias_namescatenin (cadherin-associated protein), alpha 2
Alias_symbol (synonym)CAP-R
CT114
Other aliasCAPR
CDCBM9
CTNR
HGNC (Hugo) CTNNA2
LocusID (NCBI) 1496
Atlas_Id 53898
Location 2p12  [Link to chromosome band 2p12]
Location_base_pair Starts at 79512934 and ends at 80648863 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AIG1 (6q24.2) / CTNNA2 (2p12)CTNNA2 (2p12) / AC084193.1 ()CTNNA2 (2p12) / CTNNA2 (2p12)
CTNNA2 (2p12) / RNU5F-1 (1q41)CTNNA2 (2p12) / UBXN4 (2q21.3)GLIS3 (9p24.2) / CTNNA2 (2p12)
HIBCH (2q32.2) / CTNNA2 (2p12)MAGI2 (7q21.11) / CTNNA2 (2p12)MRPL35 (2p11.2) / CTNNA2 (2p12)
PIGN (18q21.33) / CTNNA2 (2p12)PIGT (20q13.12) / CTNNA2 (2p12)GLIS3 9p24.2 / CTNNA2 2p12
HIBCH 2q32.2 / CTNNA2 2p12MRPL35 2p11.2 / CTNNA2 2p12PIGN 18q21.33 / CTNNA2 2p12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  t(2;2)(p11;p12) MRPL35/CTNNA2
t(2;2)(p12;q32) HIBCH/CTNNA2
t(2;9)(p12;p24) GLIS3/CTNNA2
t(2;18)(p12;q21) PIGN/CTNNA2

External links

Nomenclature
HGNC (Hugo)CTNNA2   2510
Cards
Entrez_Gene (NCBI)CTNNA2  1496  catenin alpha 2
AliasesCAP-R; CAPR; CDCBM9; CT114; 
CTNR
GeneCards (Weizmann)CTNNA2
Ensembl hg19 (Hinxton)ENSG00000066032 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000066032 [Gene_View]  ENSG00000066032 [Sequence]  chr2:79512934-80648863 [Contig_View]  CTNNA2 [Vega]
ICGC DataPortalENSG00000066032
TCGA cBioPortalCTNNA2
AceView (NCBI)CTNNA2
Genatlas (Paris)CTNNA2
WikiGenes1496
SOURCE (Princeton)CTNNA2
Genetics Home Reference (NIH)CTNNA2
Genomic and cartography
GoldenPath hg38 (UCSC)CTNNA2  -     chr2:79512934-80648863 +  2p12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CTNNA2  -     2p12   [Description]    (hg19-Feb_2009)
GoldenPathCTNNA2 - 2p12 [CytoView hg19]  CTNNA2 - 2p12 [CytoView hg38]
ImmunoBaseENSG00000066032
Mapping of homologs : NCBICTNNA2 [Mapview hg19]  CTNNA2 [Mapview hg38]
OMIM114025   618174   
Gene and transcription
Genbank (Entrez)AK127226 AK294362 AK295181 AK295493 AK303035
RefSeq transcript (Entrez)NM_001164883 NM_001282597 NM_001282598 NM_001282599 NM_001282600 NM_001320810 NM_004389
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CTNNA2
Cluster EST : UnigeneHs.167368 [ NCBI ]
CGAP (NCI)Hs.167368
Alternative Splicing GalleryENSG00000066032
Gene ExpressionCTNNA2 [ NCBI-GEO ]   CTNNA2 [ EBI - ARRAY_EXPRESS ]   CTNNA2 [ SEEK ]   CTNNA2 [ MEM ]
Gene Expression Viewer (FireBrowse)CTNNA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1496
GTEX Portal (Tissue expression)CTNNA2
Human Protein AtlasENSG00000066032-CTNNA2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP26232   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP26232  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP26232
Splice isoforms : SwissVarP26232
PhosPhoSitePlusP26232
Domaine pattern : Prosite (Expaxy)VINCULIN_1 (PS00663)   
Domains : Interpro (EBI)Alpha-catenin/vinculin-like_sf    Alpha_catenin    CTNNA2    Vinculin/catenin    Vinculin_CS   
Domain families : Pfam (Sanger)Vinculin (PF01044)   
Domain families : Pfam (NCBI)pfam01044   
Conserved Domain (NCBI)CTNNA2
DMDM Disease mutations1496
Blocks (Seattle)CTNNA2
SuperfamilyP26232
Human Protein Atlas [tissue]ENSG00000066032-CTNNA2 [tissue]
Peptide AtlasP26232
HPRD00228
IPIIPI00385055   IPI00743859   IPI00916487   IPI00944563   IPI00944536   IPI00514038   IPI00917211   IPI00917375   IPI01013932   
Protein Interaction databases
DIP (DOE-UCLA)P26232
IntAct (EBI)P26232
FunCoupENSG00000066032
BioGRIDCTNNA2
STRING (EMBL)CTNNA2
ZODIACCTNNA2
Ontologies - Pathways
QuickGOP26232
Ontology : AmiGOstructural constituent of cytoskeleton  protein binding  nucleus  cytoplasm  cytosol  adherens junction  cell-cell adherens junction  cytoskeleton organization  axonogenesis  regulation of neuron projection development  actin cytoskeleton  basolateral plasma membrane  radial glia guided migration of Purkinje cell  lamellipodium  axon  negative regulation of Arp2/3 complex-mediated actin nucleation  identical protein binding  cadherin binding  dendrite morphogenesis  brain morphogenesis  actin filament binding  positive regulation of muscle cell differentiation  regulation of synapse structural plasticity  prepulse inhibition  cell-cell adhesion  hippocampal mossy fiber to CA3 synapse  parallel fiber to Purkinje cell synapse  presynaptic active zone cytoplasmic component  modification of postsynaptic actin cytoskeleton  extrinsic component of presynaptic membrane  extrinsic component of postsynaptic membrane  postsynaptic density, intracellular component  regulation of neuron migration  
Ontology : EGO-EBIstructural constituent of cytoskeleton  protein binding  nucleus  cytoplasm  cytosol  adherens junction  cell-cell adherens junction  cytoskeleton organization  axonogenesis  regulation of neuron projection development  actin cytoskeleton  basolateral plasma membrane  radial glia guided migration of Purkinje cell  lamellipodium  axon  negative regulation of Arp2/3 complex-mediated actin nucleation  identical protein binding  cadherin binding  dendrite morphogenesis  brain morphogenesis  actin filament binding  positive regulation of muscle cell differentiation  regulation of synapse structural plasticity  prepulse inhibition  cell-cell adhesion  hippocampal mossy fiber to CA3 synapse  parallel fiber to Purkinje cell synapse  presynaptic active zone cytoplasmic component  modification of postsynaptic actin cytoskeleton  extrinsic component of presynaptic membrane  extrinsic component of postsynaptic membrane  postsynaptic density, intracellular component  regulation of neuron migration  
Pathways : KEGGHippo signaling pathway    Adherens junction    Tight junction    Leukocyte transendothelial migration    Bacterial invasion of epithelial cells    Pathways in cancer    Endometrial cancer    Arrhythmogenic right ventricular cardiomyopathy (ARVC)   
NDEx NetworkCTNNA2
Atlas of Cancer Signalling NetworkCTNNA2
Wikipedia pathwaysCTNNA2
Orthology - Evolution
OrthoDB1496
GeneTree (enSembl)ENSG00000066032
Phylogenetic Trees/Animal Genes : TreeFamCTNNA2
HOGENOMP26232
Homologs : HomoloGeneCTNNA2
Homology/Alignments : Family Browser (UCSC)CTNNA2
Gene fusions - Rearrangements
Fusion : MitelmanGLIS3/CTNNA2 [9p24.2/2p12]  [t(2;9)(p12;p24)]  
Fusion : MitelmanHIBCH/CTNNA2 [2q32.2/2p12]  [t(2;2)(p12;q32)]  
Fusion : MitelmanMRPL35/CTNNA2 [2p11.2/2p12]  [t(2;2)(p11;p12)]  
Fusion : MitelmanPIGN/CTNNA2 [18q21.33/2p12]  [t(2;18)(p12;q21)]  
Fusion PortalGLIS3 9p24.2 CTNNA2 2p12 HNSC
Fusion PortalHIBCH 2q32.2 CTNNA2 2p12 BRCA
Fusion PortalMRPL35 2p11.2 CTNNA2 2p12 LUSC
Fusion PortalPIGN 18q21.33 CTNNA2 2p12 BRCA
Fusion Cancer (Beijing)CTNNA2 [2p12]  -  AC084193.1 [FUSC000305]
Fusion : QuiverCTNNA2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCTNNA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CTNNA2
dbVarCTNNA2
ClinVarCTNNA2
1000_GenomesCTNNA2 
Exome Variant ServerCTNNA2
ExAC (Exome Aggregation Consortium)ENSG00000066032
GNOMAD BrowserENSG00000066032
Varsome BrowserCTNNA2
Genetic variants : HAPMAP1496
Genomic Variants (DGV)CTNNA2 [DGVbeta]
DECIPHERCTNNA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCTNNA2 
Mutations
ICGC Data PortalCTNNA2 
TCGA Data PortalCTNNA2 
Broad Tumor PortalCTNNA2
OASIS PortalCTNNA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCTNNA2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCTNNA2
Mutations and Diseases : HGMDCTNNA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CTNNA2
DgiDB (Drug Gene Interaction Database)CTNNA2
DoCM (Curated mutations)CTNNA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CTNNA2 (select a term)
intoGenCTNNA2
Cancer3DCTNNA2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM114025    618174   
Orphanet
DisGeNETCTNNA2
MedgenCTNNA2
Genetic Testing Registry CTNNA2
NextProtP26232 [Medical]
TSGene1496
GENETestsCTNNA2
Target ValidationCTNNA2
Huge Navigator CTNNA2 [HugePedia]
snp3D : Map Gene to Disease1496
BioCentury BCIQCTNNA2
ClinGenCTNNA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1496
Chemical/Pharm GKB GenePA27009
Clinical trialCTNNA2
Miscellaneous
canSAR (ICR)CTNNA2 (select the gene name)
DataMed IndexCTNNA2
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCTNNA2
EVEXCTNNA2
GoPubMedCTNNA2
iHOPCTNNA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:39:11 CET 2019
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