CTNNBIP1 (catenin beta interacting protein 1)

2003-02-01  

Identity

HGNC
CTNNBIP1
LOCATION
1p36.22
LOCUSID
56998
ALIAS
ICAT
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 56998
MIM: 607758
HGNC: 16913
Ensembl: ENSG00000178585

Variants:

dbSNP: 56998
ClinVar: 56998
TCGA: ENSG00000178585
COSMIC: CTNNBIP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178585ENST00000377256Q9NSA3
ENSG00000178585ENST00000377256A0A024R4D7
ENSG00000178585ENST00000377258Q9NSA3
ENSG00000178585ENST00000377258A0A024R4D7
ENSG00000178585ENST00000377263Q9NSA3
ENSG00000178585ENST00000377263A0A024R4D7
ENSG00000178585ENST00000400904Q9NSA3
ENSG00000178585ENST00000400904A0A024R4D7

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Wnt signaling pathwayKEGGhsa04310
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Deactivation of the beta-catenin transactivating complexREACTOMER-HSA-3769402

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
184330212008MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations.245
228158842012R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5.69
124088252002ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules.62
188522872008A genome-wide screen for beta-catenin binding sites identifies a downstream enhancer element that controls c-Myc gene expression.55
208093342011Wnt/beta-Catenin pathway in human glioma: expression pattern and clinical/prognostic correlations.52
208780572010Involvement of the Wnt-β-catenin pathway in invasion and migration of oral squamous carcinoma cells.52
253447542014ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1.46
251759162014MiR-424-5p reversed epithelial-mesenchymal transition of anchorage-independent HCC cells by directly targeting ICAT and suppressed HCC progression.40
203009722011β-Catenin overexpression in malignant glioma and its role in proliferation and apoptosis in glioblastma cells.39
236481392013Nuclear β-catenin accumulation is associated with increased expression of Nanog protein and predicts poor prognosis of non-small cell lung cancer.39

Citation

Dessen P

CTNNBIP1 (catenin beta interacting protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40195/ctnnbip1