CTPS2 (CTP synthase 2)

2003-05-01  

Identity

HGNC
CTPS2
LOCATION
Xp22.2
LOCUSID
56474
ALIAS
GATD5B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 56474
MIM: 300380
HGNC: 2520
Ensembl: ENSG00000047230

Variants:

dbSNP: 56474
ClinVar: 56474
TCGA: ENSG00000047230
COSMIC: CTPS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000047230ENST00000359276Q9NRF8
ENSG00000047230ENST00000359276A0A024RC00
ENSG00000047230ENST00000380241Q9NRF8
ENSG00000047230ENST00000380241A0A024RC00
ENSG00000047230ENST00000443824Q9NRF8
ENSG00000047230ENST00000443824A0A024RC00
ENSG00000047230ENST00000455276H0Y5S6

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pyrimidine metabolismKEGGko00240
Pyrimidine metabolismKEGGhsa00240
Metabolic pathwaysKEGGhsa01100
Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTPKEGGhsa_M00052
Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTPKEGGM00052
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Synthesis and interconversion of nucleotide di- and triphosphatesREACTOMER-HSA-499943

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
207392752010Regulation of human cytidine triphosphate synthetase 2 by phosphorylation.12
213785022011Low cytosine triphosphate synthase 2 expression renders resistance to 5-fluorouracil in colorectal cancer.6
318733032020Coupled structural transitions enable highly cooperative regulation of human CTPS2 filaments.4
212522872011Comprehensive evaluation of the contribution of X chromosome genes to platinum sensitivity.2

Citation

Dessen P

CTPS2 (CTP synthase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40200/ctps2