CTR9 (CTR9 homolog, Paf1/RNA polymerase II complex component)

2015-08-01  

Identity

HGNC
LOCATION
11p15.4
LOCUSID
ALIAS
SH2BP1,TSBP,p150,p150TSP
FUSION GENES

Other Information

Locus ID:

NCBI: 9646
MIM: 609366
HGNC: 16850
Ensembl: ENSG00000198730

Variants:

dbSNP: 9646
ClinVar: 9646
TCGA: ENSG00000198730
COSMIC: CTR9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198730ENST00000361367Q6PD62
ENSG00000198730ENST00000524523H0YCE8
ENSG00000198730ENST00000532365A0A2R8Y3S3

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Pre-transcription EventsREACTOMER-HSA-674695
RNA Polymerase II Transcription ElongationREACTOMER-HSA-75955
Formation of RNA Pol II elongation complexREACTOMER-HSA-112382
Protein ubiquitinationREACTOMER-HSA-8852135
E3 ubiquitin ligases ubiquitinate target proteinsREACTOMER-HSA-8866654

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
205414772010The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis.93
250992822014Germline mutations in the PAF1 complex gene CTR9 predispose to Wilms tumour.25
179111132007hCTR9, a component of Paf1 complex, participates in the transcription of interleukin 6-responsive genes through regulation of STAT3-DNA interactions.16
264947902015Ctr9, a key subunit of PAFc, affects global estrogen signaling and drives ERα-positive breast tumorigenesis.10
185519932008SNP combinations in chromosome-wide genes are associated with bone mineral density in Taiwanese women.9
302282572018Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation.3
235933882013CTR9, a component of PAF complex, controls elongation block at the c-Fos locus via signal-dependent regulation of chromatin-bound NELF dissociation.2
260489902015Ctr9, a Protein in the Transcription Complex Paf1, Regulates Dopamine Transporter Activity at the Plasma Membrane.2
278293572016Systematic identification of Ctr9 regulome in ERα-positive breast cancer.1
292922102018Identification of a novel CTR9 germline mutation in a family with Wilms tumor.1

Citation

Dessen P

CTR9 (CTR9 homolog, Paf1/RNA polymerase II complex component)

Atlas Genet Cytogenet Oncol Haematol. 2015-08-01

Online version: http://atlasgeneticsoncology.org/gene/55370/ctr9