CTSZ (cathepsin Z)

2003-06-01  

Identity

HGNC
LOCATION
20q13.32
LOCUSID
ALIAS
CTSX
FUSION GENES

Other Information

Locus ID:

NCBI: 1522
MIM: 603169
HGNC: 2547
Ensembl: ENSG00000101160

Variants:

dbSNP: 1522
ClinVar: 1522
TCGA: ENSG00000101160
COSMIC: CTSZ

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101160ENST00000217131Q9UBR2

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
ApoptosisKEGGko04210
ApoptosisKEGGhsa04210
LysosomeKEGGko04142
LysosomeKEGGhsa04142
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle TransportREACTOMER-HSA-204005
Peptide hormone metabolismREACTOMER-HSA-2980736
Metabolism of Angiotensinogen to AngiotensinsREACTOMER-HSA-2022377
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
trans-Golgi Network Vesicle BuddingREACTOMER-HSA-199992
Clathrin derived vesicle buddingREACTOMER-HSA-421837
Lysosome Vesicle BiogenesisREACTOMER-HSA-432720
Cargo concentration in the ERREACTOMER-HSA-5694530
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
381846272024Blood DNA methylation profiling identifies cathepsin Z dysregulation in pulmonary arterial hypertension.1
381846272024Blood DNA methylation profiling identifies cathepsin Z dysregulation in pulmonary arterial hypertension.1
370204152023Granulomatous rosacea in Chinese patients: Clinical-histopathological analysis and pathogenesis exploration.0
372102162023Defective cathepsin Z affects EGFR expression and causes autosomal dominant palmoplantar keratoderma.1
370204152023Granulomatous rosacea in Chinese patients: Clinical-histopathological analysis and pathogenesis exploration.0
372102162023Defective cathepsin Z affects EGFR expression and causes autosomal dominant palmoplantar keratoderma.1
351637062022Upregulation of Cathepsin X in Glioblastoma: Interplay with γ-Enolase and the Effects of Selective Cathepsin X Inhibitors.9
351637062022Upregulation of Cathepsin X in Glioblastoma: Interplay with γ-Enolase and the Effects of Selective Cathepsin X Inhibitors.9
343786782021Decreased levels of cathepsin Z mRNA expressed by immune blood cells: diagnostic and prognostic implications in prostate cancer.4
343786782021Decreased levels of cathepsin Z mRNA expressed by immune blood cells: diagnostic and prognostic implications in prostate cancer.4
310901992019KMT2A histone methyltransferase contributes to colorectal cancer development by promoting cathepsin Z transcriptional activation.16
310901992019KMT2A histone methyltransferase contributes to colorectal cancer development by promoting cathepsin Z transcriptional activation.16
297953042018NELFCD and CTSZ loci are associated with jaundice-stage progression in primary biliary cholangitis in the Japanese population.7
300180082018Deguelin attenuates non-small cell lung cancer cell metastasis through inhibiting the CtsZ/FAK signaling pathway.26
300469412018Cysteine cathepsins B, X and K expression in peri-arteriolar glioblastoma stem cell niches.19

Citation

Dessen P

CTSZ (cathepsin Z)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40210/ctsz