CTTN (cortactin)

2003-02-01  

Identity

HGNC
LOCATION
11q13.3
LOCUSID
ALIAS
EMS1
FUSION GENES

Other Information

Locus ID:

NCBI: 2017
MIM: 164765
HGNC: 3338
Ensembl: ENSG00000085733

Variants:

dbSNP: 2017
ClinVar: 2017
TCGA: ENSG00000085733
COSMIC: CTTN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000085733ENST00000301843Q14247
ENSG00000085733ENST00000346329Q14247
ENSG00000085733ENST00000346329A0A024R5M3
ENSG00000085733ENST00000376561Q14247
ENSG00000085733ENST00000529736H0YCD9
ENSG00000085733ENST00000533931H0YEV2

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Pathogenic Escherichia coli infectionKEGGko05130
Tight junctionKEGGhsa04530
Pathogenic Escherichia coli infectionKEGGhsa05130
ShigellosisKEGGhsa05131
Bacterial invasion of epithelial cellsKEGGko05100
Bacterial invasion of epithelial cellsKEGGhsa05100
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate PAKsREACTOMER-HSA-5627123
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Clathrin-mediated endocytosisREACTOMER-HSA-8856828

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
176433702007HDAC6 modulates cell motility by altering the acetylation level of cortactin.230
174833342007Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular matrix degradation in invadopodia.189
150566552004Pulmonary endothelial cell barrier enhancement by sphingosine 1-phosphate: roles for cortactin and myosin light chain kinase.133
160511702005Cortactin promotes cell motility by enhancing lamellipodial persistence.124
212577112011An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion.114
151698912004Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP.106
184060522008Cortactin in tumor invasiveness.85
221053492011Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway.84
223780442012β₁Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy.84
126728172003A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton.78

Citation

Dessen P

CTTN (cortactin)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/369/cttn