CUEDC2 (CUE domain containing 2)

2007-07-01  

Identity

HGNC
LOCATION
10q24.32
LOCUSID
ALIAS
C10orf66,bA18I14.5
FUSION GENES

Other Information

Locus ID:

NCBI: 79004
MIM: 614142
HGNC: 28352
Ensembl: ENSG00000107874

Variants:

dbSNP: 79004
ClinVar: 79004
TCGA: ENSG00000107874
COSMIC: CUEDC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107874ENST00000369937Q9H467

Expression (GTEx)

0
50
100
150
200

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
215724282011Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer.51
217434652011Cdk1-phosphorylated CUEDC2 promotes spindle checkpoint inactivation and chromosomal instability.28
173476542007CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasome.26
248820112014Dysregulation of the miR-324-5p-CUEDC2 axis leads to macrophage dysfunction and is associated with colon cancer.20
220842472012CUEDC2 (CUE domain-containing 2) and SOCS3 (suppressors of cytokine signaling 3) cooperate to negatively regulate Janus kinase 1/signal transducers and activators of transcription 3 signaling.14
237762052013Phosphorylation-triggered CUEDC2 degradation promotes UV-induced G1 arrest through APC/C(Cdh1) regulation.7
283257732017CUE domain-containing protein 2 promotes the Warburg effect and tumorigenesis.7
241258382013CUEDC2 sensitizes chronic myeloid leukemic cells to imatinib treatment.6
260237332015CUEDC2 down-regulation is associated with tumor growth and poor prognosis in lung adenocarcinoma.5

Citation

Dessen P

CUEDC2 (CUE domain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47645/cuedc2