CUL1 (cullin 1)

2003-02-01  

Identity

HGNC
LOCATION
7q36.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 8454
MIM: 603134
HGNC: 2551
Ensembl: ENSG00000055130

Variants:

dbSNP: 8454
ClinVar: 8454
TCGA: ENSG00000055130
COSMIC: CUL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000055130ENST00000325222Q13616
ENSG00000055130ENST00000325222A0A090N7U0
ENSG00000055130ENST00000409469Q13616
ENSG00000055130ENST00000409469A0A090N7U0
ENSG00000055130ENST00000602748Q13616
ENSG00000055130ENST00000602748A0A090N7U0
ENSG00000055130ENST00000617797A0A0C4DGX4
ENSG00000055130ENST00000655324A0A590UK34
ENSG00000055130ENST00000656001A0A590UJ56
ENSG00000055130ENST00000660013A0A590UJA0
ENSG00000055130ENST00000660240A0A590UJC4
ENSG00000055130ENST00000662132A0A590UJ50
ENSG00000055130ENST00000662670A0A590UJ97
ENSG00000055130ENST00000662716Q13616
ENSG00000055130ENST00000662716A0A090N7U0
ENSG00000055130ENST00000663044Q13616
ENSG00000055130ENST00000663044A0A090N7U0
ENSG00000055130ENST00000663835A0A590UJR3
ENSG00000055130ENST00000665936Q13616
ENSG00000055130ENST00000665936A0A090N7U0
ENSG00000055130ENST00000666124A0A590UJ21
ENSG00000055130ENST00000671397A0A590UJM8
ENSG00000055130ENST00000671421A0A590UJ59

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Ubiquitin mediated proteolysisKEGGko04120
Wnt signaling pathwayKEGGko04310
Hedgehog signaling pathwayKEGGko04340
TGF-beta signaling pathwayKEGGko04350
Circadian rhythmKEGGko04710
Cell cycleKEGGhsa04110
Ubiquitin mediated proteolysisKEGGhsa04120
Wnt signaling pathwayKEGGhsa04310
Hedgehog signaling pathwayKEGGhsa04340
TGF-beta signaling pathwayKEGGhsa04350
Circadian rhythmKEGGhsa04710
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
SCF-BTRC complexKEGGhsa_M00380
SCF-SKP2 complexKEGGhsa_M00381
SCF-FBS complexKEGGhsa_M00382
SCF-FBW7 complexKEGGhsa_M00387
SCF-FBS complexKEGGM00382
SCF-BTRC complexKEGGM00380
SCF-SKP2 complexKEGGM00381
SCF-FBW7 complexKEGGM00387
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by NOTCH1 in CancerREACTOMER-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in CancerREACTOMER-HSA-2644602
Constitutive Signaling by NOTCH1 PEST Domain MutantsREACTOMER-HSA-2644606
Signaling by NOTCH1 HD+PEST Domain Mutants in CancerREACTOMER-HSA-2894858
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsREACTOMER-HSA-2894862
FBXW7 Mutants and NOTCH1 in CancerREACTOMER-HSA-2644605
Loss of Function of FBXW7 in Cancer and NOTCH1 SignalingREACTOMER-HSA-2644607
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
TCR signalingREACTOMER-HSA-202403
Downstream TCR signalingREACTOMER-HSA-202424
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)REACTOMER-HSA-1168372
Activation of NF-kappaB in B cellsREACTOMER-HSA-1169091
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 10 (TLR10) CascadeREACTOMER-HSA-168142
MyD88 cascade initiated on plasma membraneREACTOMER-HSA-975871
MAP kinase activation in TLR cascadeREACTOMER-HSA-450294
Toll Like Receptor 3 (TLR3) CascadeREACTOMER-HSA-168164
MyD88-independent TLR3/TLR4 cascadeREACTOMER-HSA-166166
TRIF-mediated TLR3/TLR4 signalingREACTOMER-HSA-937061
Toll Like Receptor 5 (TLR5) CascadeREACTOMER-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) CascadeREACTOMER-HSA-168181
MyD88 dependent cascade initiated on endosomeREACTOMER-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationREACTOMER-HSA-975138
Toll Like Receptor 9 (TLR9) CascadeREACTOMER-HSA-168138
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
MyD88:Mal cascade initiated on plasma membraneREACTOMER-HSA-166058
Toll Like Receptor 2 (TLR2) CascadeREACTOMER-HSA-181438
Toll Like Receptor TLR1:TLR2 CascadeREACTOMER-HSA-168179
Toll Like Receptor TLR6:TLR2 CascadeREACTOMER-HSA-168188
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
FCERI mediated NF-kB activationREACTOMER-HSA-2871837
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
CLEC7A (Dectin-1) signalingREACTOMER-HSA-5607764
Dectin-1 mediated noncanonical NF-kB signalingREACTOMER-HSA-5607761
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-1 signalingREACTOMER-HSA-446652
Prolactin receptor signalingREACTOMER-HSA-1170546
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
NIK-->noncanonical NF-kB signalingREACTOMER-HSA-5676590
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
NOTCH1 Intracellular Domain Regulates TranscriptionREACTOMER-HSA-2122947
Signaling by WntREACTOMER-HSA-195721
Degradation of beta-catenin by the destruction complexREACTOMER-HSA-195253
Signaling by HedgehogREACTOMER-HSA-5358351
Hedgehog 'off' stateREACTOMER-HSA-5610787
GLI3 is processed to GLI3R by the proteasomeREACTOMER-HSA-5610785
Degradation of GLI2 by the proteasomeREACTOMER-HSA-5610783
Degradation of GLI1 by the proteasomeREACTOMER-HSA-5610780
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1 PhaseREACTOMER-HSA-69236
Cyclin D associated events in G1REACTOMER-HSA-69231
G1/S TransitionREACTOMER-HSA-69206
Cyclin E associated events during G1/S transitionREACTOMER-HSA-69202
SCF(Skp2)-mediated degradation of p27/p21REACTOMER-HSA-187577
S PhaseREACTOMER-HSA-69242
Cyclin A:Cdk2-associated events at S phase entryREACTOMER-HSA-69656
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Regulation of mitotic cell cycleREACTOMER-HSA-453276
APC/C-mediated degradation of cell cycle proteinsREACTOMER-HSA-174143
Regulation of APC/C activators between G1/S and early anaphaseREACTOMER-HSA-176408
SCF-beta-TrCP mediated degradation of Emi1REACTOMER-HSA-174113
Circadian ClockREACTOMER-HSA-400253
MAP3K8 (TPL2)-dependent MAPK1/3 activationREACTOMER-HSA-5684264
FBXL7 down-regulates AURKA during mitotic entry and in early mitosisREACTOMER-HSA-8854050

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
119615462002Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.546
125040252002NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases.126
125040262002CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex.112
199453792009Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substrates.92
254887492015Whole-exome sequencing reveals frequent genetic alterations in BAP1, NF2, CDKN2A, and CUL1 in malignant pleural mesothelioma.66
127593632003DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1.65
119671552002The COP9 signalosome inhibits p27(kip1) degradation and impedes G1-S phase progression via deneddylation of SCF Cul1.63
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
187236772008Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail.59
168613002006Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate.57

Citation

Dessen P

CUL1 (cullin 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40211/cul1