CUL4B (cullin 4B)

2003-02-01  

Identity

HGNC
LOCATION
Xq24
LOCUSID
ALIAS
CUL-4B,MRXHF2,MRXS15,MRXSC,SFM2
FUSION GENES

Other Information

Locus ID:

NCBI: 8450
MIM: 300304
HGNC: 2555
Ensembl: ENSG00000158290

Variants:

dbSNP: 8450
ClinVar: 8450
TCGA: ENSG00000158290
COSMIC: CUL4B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158290ENST00000336592K4DI93
ENSG00000158290ENST00000371322Q13620
ENSG00000158290ENST00000371323A6NE76
ENSG00000158290ENST00000404115Q13620

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Nucleotide excision repairKEGGko03420
Ubiquitin mediated proteolysisKEGGko04120
Nucleotide excision repairKEGGhsa03420
Ubiquitin mediated proteolysisKEGGhsa04120
Cul4-DDB1-DDB2 complexKEGGhsa_M00385
Cul4-DDB1-CSA complexKEGGhsa_M00386
Cul4-DDB1-DDB2 complexKEGGM00385
Cul4-DDB1-CSA complexKEGGM00386
DNA RepairREACTOMER-HSA-73894
DNA Damage BypassREACTOMER-HSA-73893
Recognition of DNA damage by PCNA-containing replication complexREACTOMER-HSA-110314
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
DNA Damage Recognition in GG-NERREACTOMER-HSA-5696394
Formation of Incision Complex in GG-NERREACTOMER-HSA-5696395
Dual Incision in GG-NERREACTOMER-HSA-5696400
Transcription-Coupled Nucleotide Excision Repair (TC-NER)REACTOMER-HSA-6781827
Formation of TC-NER Pre-Incision ComplexREACTOMER-HSA-6781823
Dual incision in TC-NERREACTOMER-HSA-6782135
Gap-filling DNA repair synthesis and ligation in TC-NERREACTOMER-HSA-6782210

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198186322009CRL4s: the CUL4-RING E3 ubiquitin ligases.161
173927872007Dioxin receptor is a ligand-dependent E3 ubiquitin ligase.158
209324712010CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation.127
164072522006PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination.124
209519432010Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase.96
172361392007Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor.81
163226932006Involvement of CUL4 ubiquitin E3 ligases in regulating CDK inhibitors Dacapo/p27Kip1 and cyclin E degradation.57
185938992008The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A.53
172739782007Mutation in CUL4B, which encodes a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardation.52
198015442009Characterization of nuclear localization signal in the N terminus of CUL4B and its essential role in cyclin E degradation and cell cycle progression.46

Citation

Dessen P

CUL4B (cullin 4B)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40215/cul4b