CYBB (cytochrome b-245 beta chain)

2007-02-01  

Identity

HGNC
LOCATION
Xp21.1
LOCUSID
ALIAS
AMCBX2,CGD,CGDX,GP91-1,GP91-PHOX,GP91PHOX,IMD34,NOX2,p91-PHOX
FUSION GENES

Other Information

Locus ID:

NCBI: 1536
MIM: 300481
HGNC: 2578
Ensembl: ENSG00000165168

Variants:

dbSNP: 1536
ClinVar: 1536
TCGA: ENSG00000165168
COSMIC: CYBB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165168ENST00000378588P04839
ENSG00000165168ENST00000378588A0A0S2Z3S6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Leukocyte transendothelial migrationKEGGko04670
Leukocyte transendothelial migrationKEGGhsa04670
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
HIF-1 signaling pathwayKEGGhsa04066
ROS, RNS production in phagocytesREACTOMER-HSA-1222556
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing-Cross presentationREACTOMER-HSA-1236975
Cross-presentation of particulate exogenous antigens (phagosomes)REACTOMER-HSA-1236973
Innate Immune SystemREACTOMER-HSA-168249
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate NADPH OxidasesREACTOMER-HSA-5668599
Cellular responses to stressREACTOMER-HSA-2262752
Detoxification of Reactive Oxygen SpeciesREACTOMER-HSA-3299685
AGE-RAGE signaling pathway in diabetic complicationsKEGGko04933
AGE-RAGE signaling pathway in diabetic complicationsKEGGhsa04933
Neutrophil degranulationREACTOMER-HSA-6798695
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
168398872006NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells.307
182021722008Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein.142
257308482015SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx.121
157060792005Expression and localization of NOX2 and NOX4 in primary human endothelial cells.117
186825992008NADPH oxidase controls phagosomal pH and antigen cross-presentation in human dendritic cells.107
204950742010Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease.102
118937322002Intracellular localization and preassembly of the NADPH oxidase complex in cultured endothelial cells.96
163546862006Nox2 and Rac1 regulate H2O2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes.96
169870042006NOX2 and NOX4 mediate proliferative response in endothelial cells.95
212787362011Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease.85

Citation

Dessen P

CYBB (cytochrome b-245 beta chain)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46322/cybb