Identity
HGNC
LOCATION
10q24.32
LOCUSID
ALIAS
CPT7,CYP17,P450C17,S17AH
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1586
MIM: 609300
HGNC: 2593
Ensembl: ENSG00000148795
Variants:
dbSNP: 1586
ClinVar: 1586
TCGA: ENSG00000148795
COSMIC: CYP17A1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166123407 | abiraterone | Chemical | MultilinkAnnotation | associated | 25157341 | ||
| PA452347 | glucocorticoids | Chemical | MultilinkAnnotation | associated | 25157341 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38104728 | 2024 | Prostate cancer androgen biosynthesis relies solely on CYP17A1 downstream metabolites. | 0 |
| 38280431 | 2024 | Proteomics, modeling, and fluorescence assays delineate cytochrome b(5) residues involved in binding and stimulation of cytochrome P450 17A1 17,20-lyase. | 0 |
| 38842434 | 2024 | Tracking protein-protein interactions by NMR: conformational selection in human steroidogenic cytochrome P450 CYP17A1 induced by cytochrome b(5). | 0 |
| 38104728 | 2024 | Prostate cancer androgen biosynthesis relies solely on CYP17A1 downstream metabolites. | 0 |
| 38280431 | 2024 | Proteomics, modeling, and fluorescence assays delineate cytochrome b(5) residues involved in binding and stimulation of cytochrome P450 17A1 17,20-lyase. | 0 |
| 38842434 | 2024 | Tracking protein-protein interactions by NMR: conformational selection in human steroidogenic cytochrome P450 CYP17A1 induced by cytochrome b(5). | 0 |
| 37370070 | 2023 | Mutated CYP17A1 promotes atherosclerosis and early-onset coronary artery disease. | 1 |
| 37539608 | 2023 | CYP17A1 (rs74357) polymorphism and polycystic ovary syndrome risk: a systemic review and meta-analysis. | 0 |
| 37370070 | 2023 | Mutated CYP17A1 promotes atherosclerosis and early-onset coronary artery disease. | 1 |
| 37539608 | 2023 | CYP17A1 (rs74357) polymorphism and polycystic ovary syndrome risk: a systemic review and meta-analysis. | 0 |
| 34655046 | 2022 | Aberrant H19 Expression Disrupts Ovarian Cyp17 and Testosterone Production and Is Associated with Polycystic Ovary Syndrome in Women. | 5 |
| 34724156 | 2022 | A rare cause of delayed puberty and primary amenorrhea: 17α-hydroxylase enzyme deficiency. | 3 |
| 35287432 | 2022 | Importance of Asparagine 202 in Manipulating Active Site Structure and Substrate Preference for Human CYP17A1. | 3 |
| 35366770 | 2022 | Insights into Interactions of Human Cytochrome P450 17A1: A Review. | 1 |
| 36293479 | 2022 | A Role of DNA Methylation within the CYP17A1 Gene in the Association of Genetic and Environmental Risk Factors with Stress-Related Manifestations of Schizophrenia. | 0 |
Citation
Dessen P
CYP17A1 (cytochrome P450 family 17 subfamily A member 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40233/cyp17a1
