CYP17A1 (cytochrome P450 family 17 subfamily A member 1)

2003-02-01  

Identity

HGNC
LOCATION
10q24.32
LOCUSID
ALIAS
CPT7,CYP17,P450C17,S17AH
FUSION GENES

Other Information

Locus ID:

NCBI: 1586
MIM: 609300
HGNC: 2593
Ensembl: ENSG00000148795

Variants:

dbSNP: 1586
ClinVar: 1586
TCGA: ENSG00000148795
COSMIC: CYP17A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148795ENST00000369887P05093
ENSG00000148795ENST00000369887Q1HB44
ENSG00000148795ENST00000638190A0A1W2PRY0
ENSG00000148795ENST00000638272A0A1W2PQ28
ENSG00000148795ENST00000638971A0A1W2PQT5
ENSG00000148795ENST00000639393A0A1W2PRK7

Expression (GTEx)

0
1000
2000
3000
4000
5000
6000
7000

Pathways

PathwaySourceExternal ID
Steroid hormone biosynthesisKEGGko00140
Steroid hormone biosynthesisKEGGhsa00140
Metabolic pathwaysKEGGhsa01100
C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estroneKEGGhsa_M00110
C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisoneKEGGhsa_M00109
C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estroneKEGGM00110
C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisoneKEGGM00109
Ovarian steroidogenesisKEGGhsa04913
Ovarian steroidogenesisKEGGko04913
Prolactin signaling pathwayKEGGhsa04917
Prolactin signaling pathwayKEGGko04917
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Metabolism of steroid hormonesREACTOMER-HSA-196071
Glucocorticoid biosynthesisREACTOMER-HSA-194002
Androgen biosynthesisREACTOMER-HSA-193048
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897
Endogenous sterolsREACTOMER-HSA-211976

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166123407abirateroneChemicalMultilinkAnnotationassociated25157341
PA452347glucocorticoidsChemicalMultilinkAnnotationassociated25157341

References

Pubmed IDYearTitleCitations
194304792009Genome-wide association study of blood pressure and hypertension.542
194304832009Genome-wide association study identifies eight loci associated with blood pressure.476
218687582011Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors.151
114709932001Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver.113
151991132004Polymorphisms associated with circulating sex hormone levels in postmenopausal women.103
195982352009Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.92
195982352009Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.92
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
222669432012Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001.83
200861732010Evidence of limited contributions for intratumoral steroidogenesis in prostate cancer.71

Citation

Dessen P

CYP17A1 (cytochrome P450 family 17 subfamily A member 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40233/cyp17a1