Identity
HGNC
LOCATION
2p22.2
LOCUSID
ALIAS
ASGD6,CP1B,CYPIB1,GLC3A,P4501B1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1545
MIM: 601771
HGNC: 2597
Ensembl: ENSG00000138061
Variants:
dbSNP: 1545
ClinVar: 1545
TCGA: ENSG00000138061
COSMIC: CYP1B1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000138061 | ENST00000490576 | A0A087WUQ7 |
| ENSG00000138061 | ENST00000494864 | A0A087WW26 |
| ENSG00000138061 | ENST00000610745 | Q16678 |
| ENSG00000138061 | ENST00000614273 | Q16678 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA128406956 | fluorouracil | Chemical | ClinicalAnnotation | associated | PD | 24958282 | |
| PA443560 | Breast Neoplasms | Disease | ClinicalAnnotation | associated | PD | 24599932, 24958282 | |
| PA447216 | Schizophrenia | Disease | ClinicalAnnotation | associated | PD | ||
| PA448404 | amodiaquine | Chemical | Pathway | associated | |||
| PA449165 | cyclophosphamide | Chemical | ClinicalAnnotation | associated | PD | 24599932, 24958282 | |
| PA449383 | docetaxel | Chemical | Pathway | associated | 21151855 | ||
| PA449412 | doxorubicin | Chemical | ClinicalAnnotation | associated | PD | ||
| PA449476 | epirubicin | Chemical | ClinicalAnnotation | associated | PD | 24599932, 24958282 | |
| PA450761 | paclitaxel | Chemical | ClinicalAnnotation, Pathway | associated | PD | 21151855, 24599932 | |
| PA451257 | risperidone | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37661069 | 2024 | Enhancing the invasive traits of breast cancers by CYP1B1 via regulation of p53 to promote uPAR expression. | 1 |
| 37788597 | 2024 | Variable Phenotype of Congenital Corneal Opacities in Biallelic CYP1B1 Pathogenic Variants. | 0 |
| 38429921 | 2024 | CYP1B1 affects the integrity of the blood-brain barrier and oxidative stress in the striatum: An investigation of manganese-induced neurotoxicity. | 0 |
| 38479850 | 2024 | Circ_0020887 Silencing Combats Hypoxic-Induced Cardiomyocyte Injury in an MiR-370-3p/CYP1B1-Dependent Manner. | 0 |
| 38701513 | 2024 | Cytochrome P450 1B1 is critical in the development of TNF-α, IL-6, and LPS-induced cellular hypertrophy. | 0 |
| 37661069 | 2024 | Enhancing the invasive traits of breast cancers by CYP1B1 via regulation of p53 to promote uPAR expression. | 1 |
| 37788597 | 2024 | Variable Phenotype of Congenital Corneal Opacities in Biallelic CYP1B1 Pathogenic Variants. | 0 |
| 38429921 | 2024 | CYP1B1 affects the integrity of the blood-brain barrier and oxidative stress in the striatum: An investigation of manganese-induced neurotoxicity. | 0 |
| 38479850 | 2024 | Circ_0020887 Silencing Combats Hypoxic-Induced Cardiomyocyte Injury in an MiR-370-3p/CYP1B1-Dependent Manner. | 0 |
| 38701513 | 2024 | Cytochrome P450 1B1 is critical in the development of TNF-α, IL-6, and LPS-induced cellular hypertrophy. | 0 |
| 34526297 | 2023 | CYP1B1 and MYOC variants in neonatal-onset versus infantile-onset primary congenital glaucoma. | 3 |
| 36442682 | 2023 | Human CYP1B1 enzyme-mediated, AhR enhanced activation of aflatoxin B1 for its genotoxicity in human cells. | 1 |
| 36634630 | 2023 | CYP1B1 Genetic Variants (rs10916 and rs2855658) Are Associated with Increased Risk of Ischemic Stroke in Chinese Han Population. | 1 |
| 37371125 | 2023 | Human Adult Renal Progenitor Cells Prevent Cisplatin-Nephrotoxicity by Inducing CYP1B1 Overexpression and miR-27b-3p Down-Regulation through Extracellular Vesicles. | 0 |
| 37442234 | 2023 | Mitochondrial cytochrome P450 1B1 is involved in pregnenolone synthesis in human brain cells. | 1 |
Citation
Dessen P
CYP1B1 (cytochrome P450 family 1 subfamily B member 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40237/cyp1b1
