Identity
HGNC
LOCATION
20q13.2
LOCUSID
ALIAS
CP24,CYP24,HCAI,HCINF1,P450-CC24
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1591
MIM: 126065
HGNC: 2602
Ensembl: ENSG00000019186
Variants:
dbSNP: 1591
ClinVar: 1591
TCGA: ENSG00000019186
COSMIC: CYP24A1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000019186 | ENST00000216862 | Q07973 |
| ENSG00000019186 | ENST00000395954 | Q07973 |
| ENSG00000019186 | ENST00000395955 | Q07973 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA162263533 | nephrotoxicity | Disease | ClinicalAnnotation | associated | PD | 31619748 | |
| PA164760843 | deferasirox | Chemical | ClinicalAnnotation | associated | PK | 29099735, 29160302 | |
| PA165958354 | telaprevir | Chemical | ClinicalAnnotation | associated | PK | 26158282 | |
| PA166201941 | tenofovir disoproxil fumarate | Chemical | ClinicalAnnotation | associated | PD | 31619748 | |
| PA444445 | Hepatitis C | Disease | ClinicalAnnotation | associated | PK | 26158282 | |
| PA446432 | beta-Thalassemia | Disease | ClinicalAnnotation | associated | PK | 29099735, 29160302 | |
| PA447230 | HIV Infections | Disease | ClinicalAnnotation | associated | PD | 31619748 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38350553 | 2024 | MicroRNA-125b regulates vitamin D resistance by targeting CYP24A1 in the progression of gestational diabetes mellitus. | 0 |
| 38504242 | 2024 | Biallelic and monoallelic pathogenic variants in CYP24A1 and SLC34A1 genes cause idiopathic infantile hypercalcemia. | 0 |
| 38632160 | 2024 | Gene expression profiling of vitamin D metabolism enzymes in leukemia and lymphoma patients: molecular aspect interplay of VDR, CYP2R1, and CYP24A1. | 1 |
| 38839691 | 2024 | Zika virus infection suppresses CYP24A1 and CAMP expression in human monocytes. | 0 |
| 38350553 | 2024 | MicroRNA-125b regulates vitamin D resistance by targeting CYP24A1 in the progression of gestational diabetes mellitus. | 0 |
| 38504242 | 2024 | Biallelic and monoallelic pathogenic variants in CYP24A1 and SLC34A1 genes cause idiopathic infantile hypercalcemia. | 0 |
| 38632160 | 2024 | Gene expression profiling of vitamin D metabolism enzymes in leukemia and lymphoma patients: molecular aspect interplay of VDR, CYP2R1, and CYP24A1. | 1 |
| 38839691 | 2024 | Zika virus infection suppresses CYP24A1 and CAMP expression in human monocytes. | 0 |
| 36542209 | 2023 | Circular RNA Circ_0005962 Contributes to Lung Adenocarcinoma Cell Proliferation and Stem Cell Formation Through Sponging of miR-3611 and Modulating CYP24A1 Expression. | 0 |
| 36625425 | 2023 | 3' Untranslated Region Structural Elements in CYP24A1 Are Associated With Infantile Hypercalcemia Type 1. | 0 |
| 36833234 | 2023 | Association of CYP24A1 Gene rs6127099 (A > T) Polymorphism with Lower Risk to COVID-19 Infection in Kazakhstan. | 1 |
| 36928289 | 2023 | Suppression of the vitamin D metabolizing enzyme CYP24A1 provides increased sensitivity to chemotherapeutic drugs in breast cancer. | 2 |
| 37244301 | 2023 | Local production of active vitamin D(3) metabolites in breast cancer cells by CYP24A1 and CYP27B1. | 2 |
| 37414755 | 2023 | USP11-mediated LSH deubiquitination inhibits ferroptosis in colorectal cancer through epigenetic activation of CYP24A1. | 4 |
| 37670334 | 2023 | Genetic polymorphisms of CYP24A1 gene and cancer susceptibility: a meta-analysis including 40640 subjects. | 0 |
Citation
Dessen P
CYP24A1 (cytochrome P450 family 24 subfamily A member 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40239/cyp24a1
