Identity
HGNC
LOCATION
2q35
LOCUSID
ALIAS
CP27,CTX,CYP27
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1593
MIM: 606530
HGNC: 2605
Ensembl: ENSG00000135929
Variants:
dbSNP: 1593
ClinVar: 1593
TCGA: ENSG00000135929
COSMIC: CYP27A1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000135929 | ENST00000258415 | Q02318 |
| ENSG00000135929 | ENST00000411688 | C9J1K5 |
| ENSG00000135929 | ENST00000445971 | F8WD90 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166160055 | cholic acid | Chemical | LabelAnnotation | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38183874 | 2024 | Global spread characteristics of CTX-M-type extended-spectrum β-lactamases: A genomic epidemiology analysis. | 1 |
| 38336741 | 2024 | Cerebrotendinous Xanthomatosis patients with late diagnosed in single orthopedic clinic: two novel variants in the CYP27A1 gene. | 0 |
| 38704863 | 2024 | Methyl-CpG-binding protein 2 regulates CYP27A1-induced myometrial contraction during preterm labor. | 0 |
| 38183874 | 2024 | Global spread characteristics of CTX-M-type extended-spectrum β-lactamases: A genomic epidemiology analysis. | 1 |
| 38336741 | 2024 | Cerebrotendinous Xanthomatosis patients with late diagnosed in single orthopedic clinic: two novel variants in the CYP27A1 gene. | 0 |
| 38704863 | 2024 | Methyl-CpG-binding protein 2 regulates CYP27A1-induced myometrial contraction during preterm labor. | 0 |
| 36811281 | 2023 | The Interaction Effect of 27-Hydroxycholesterol Metabolism Disorder and CYP27A1 Single Nucleotide Polymorphisms in Mild Cognitive Impairment: Evidence from a Case-Control Study. | 2 |
| 36872411 | 2023 | TUBB2B facilitates progression of hepatocellular carcinoma by regulating cholesterol metabolism through targeting HNF4A/CYP27A1. | 1 |
| 37981011 | 2023 | 27-Hydroxylation of oncosterone by CYP27A1 switches its activity from pro-tumor to anti-tumor. | 0 |
| 36811281 | 2023 | The Interaction Effect of 27-Hydroxycholesterol Metabolism Disorder and CYP27A1 Single Nucleotide Polymorphisms in Mild Cognitive Impairment: Evidence from a Case-Control Study. | 2 |
| 36872411 | 2023 | TUBB2B facilitates progression of hepatocellular carcinoma by regulating cholesterol metabolism through targeting HNF4A/CYP27A1. | 1 |
| 37981011 | 2023 | 27-Hydroxylation of oncosterone by CYP27A1 switches its activity from pro-tumor to anti-tumor. | 0 |
| 34930075 | 2022 | Analysis of CYP27A1 mutations in Han Chinese women with intrahepatic cholestasis of pregnancy. | 0 |
| 35810773 | 2022 | CYP27A1 inhibits proliferation and migration of clear cell renal cell carcinoma via activation of LXRs/ABCA1. | 6 |
| 35969149 | 2022 | The tumor-repressing effect of CYP27A1 on renal cell carcinoma by 27-HC arising from cholesterol metabolism. | 2 |
Citation
Dessen P
CYP27A1 (cytochrome P450 family 27 subfamily A member 1)
Atlas Genet Cytogenet Oncol Haematol. 2009-05-01
Online version: http://atlasgeneticsoncology.org/gene/50913/cyp27a1
