CYP2C19 (cytochrome P450 family 2 subfamily C member 19)

2003-08-01  

Identity

HGNC
LOCATION
10q23.33
LOCUSID
ALIAS
CPCJ,CYP2C,CYPIIC17,CYPIIC19,P450C2C,P450IIC19
FUSION GENES

Other Information

Locus ID:

NCBI: 1557
MIM: 124020
HGNC: 2621
Ensembl: ENSG00000165841

Variants:

dbSNP: 1557
ClinVar: 1557
TCGA: ENSG00000165841
COSMIC: CYP2C19

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165841ENST00000371321P33261
ENSG00000165841ENST00000480405A0A087X125

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Arachidonic acid metabolismKEGGko00590
Linoleic acid metabolismKEGGko00591
Drug metabolism - cytochrome P450KEGGko00982
Arachidonic acid metabolismKEGGhsa00590
Linoleic acid metabolismKEGGhsa00591
Drug metabolism - cytochrome P450KEGGhsa00982
Metabolic pathwaysKEGGhsa01100
Serotonergic synapseKEGGhsa04726
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)REACTOMER-HSA-2142816
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)REACTOMER-HSA-2142670
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897
XenobioticsREACTOMER-HSA-211981
CYP2E1 reactionsREACTOMER-HSA-211999

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10066duloxetineChemicalVariantAnnotationnot associatedPD23545896
PA10074escitalopramChemicalClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGeneambiguousPKPD20492469, 7969038, 8195181, 8563772, 11802100, 12222994, 12975335, 15168101, 16413245, 16418702, 16855453, 17625515, 18654768, 19404631, 19593158, 19773541, 19840783, 20350136, 20531370, 21926427, 23545896, 23981149, 24014145, 24257813, 24858822, 25122046, 25154506, 25974703, 28614176, 29325448, 30135031, 30983508, 8451774, 8835706
PA10075esomeprazoleChemicalClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotation, VipGeneambiguousPKPD16338278, 18637061, 18751689, 19166419, 19785625, 21118735, 22324425
PA10233voriconazoleChemicalClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGeneambiguousPKPD17625515, 20083681, 8195181, 15179414, 16003289, 16413245, 16890574, 17827141, 18982321, 19033450, 19261446, 19299322, 19933691, 20669013, 21038076, 21192313, 21383338, 21507170, 21831685, 23215888, 23588332, 24510446, 24554646, 25084200, 25155930, 25239277, 25558073, 25986028, 26024717, 26239729, 26616742, 26775563, 26861072, 26982740, 27056297, 27143031, 27284960, 27388292, 27432796, 27937048, 28685218, 28834922, 29285995, 29393850, 29607533
PA10251atazanavirChemicalLabelAnnotationassociated
PA10402benzodiazepine derivativesChemicalVipGeneassociated8148870
PA10888clobazamChemicalClinicalAnnotation, LabelAnnotation, VariantAnnotationambiguousPKPD12451290, 14729419, 15483195, 15533655, 18466100, 23666564, 24345815, 25323806
PA126CYP2C9GeneDataAnnotationassociated
PA128CYP2D6GeneDataAnnotationassociated
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD
PA1318870083,4-methylenedioxymethamphetamineChemicalClinicalAnnotation, VariantAnnotationassociatedPKPD28117133
PA133950441hmg coa reductase inhibitorsChemicalPathwayassociated
PA134308647rosuvastatinChemicalVariantAnnotationambiguousPK23930675, 24140730
PA134687907formoterolChemicalLabelAnnotationassociated
PA151958426nebivololChemicalVariantAnnotationambiguousPK29098786
PA153619833Peripheral Vascular DiseasesDiseaseVariantAnnotationassociatedPD27464309
PA154410481prasugrelChemicalClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotationambiguousPKPD17900275, 20492467, 23257377, 24402637, 25008027, 26151596, 26556524
PA162316739Maculopapular ExanthemaDiseaseClinicalAnnotationassociatedPD
PA162370415Metabolic SyndromeDiseaseVariantAnnotationassociatedPD
PA164713207Proton pump inhibitorsChemicalLiterature, MultilinkAnnotation, VipGeneassociated15258107, 16772608, 21412232, 8148870, 8195181, 15199661, 25303292
PA164743150labetalolChemicalVariantAnnotationassociatedPK23090703
PA164746334cilostazolChemicalVariantAnnotationambiguousPKPD21345843, 21511217
PA164746757tolterodineChemicalLabelAnnotationassociated
PA164781320flunitrazepamChemicalPathwayassociated
PA164784021ethambutolChemicalClinicalAnnotationassociatedPD
PA164924493axitinibChemicalLabelAnnotation, VariantAnnotationambiguousPK22170007
PA164925725Toxic liver diseaseDiseaseVariantAnnotationnot associatedPD27284960
PA165108401Acute coronary syndromeDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD16772608, 17697139, 17900275, 18004210, 18323861, 18346178, 18394438, 18482659, 18532997, 18577829, 18781853, 19106083, 19106084, 19108880, 19193675, 19268736, 19463375, 19531897, 19576320, 19624462, 19926050, 19934793, 20083681, 20351750, 20492469, 20510210, 20620727, 20650435, 20708365, 20724801, 20801498, 20826260, 20833683, 20845077, 20924183, 20965456, 20979470, 21075428, 21099121, 21163112, 21168310, 21178986, 21527445, 21628721, 21700758, 21716274, 21806387, 21831410, 21918510, 21972404, 22028352, 22045970, 22088980, 22228204, 22285300, 22374717, 22390861, 22462746, 22464343, 22624833, 22704413, 22940005, 22955794, 22974728, 22990067, 23001453, 23150151, 23257377, 23364775, 23429358, 23640828, 23692149, 23726091, 23922007, 24019397, 24080325, 24088578, 24214141, 24418943, 24504666, 24508947, 24535487, 24608794, 24821368, 24856643, 25008027, 25542807, 25712182, 25730082, 25828136, 25860557, 25897911, 26151596, 26265231, 26873108, 27450232, 28589365, 28604225, 28806186, 29723426
PA165290928drospirenone / ethinyl estradiolChemicalLabelAnnotationassociated
PA165374639suicideDiseaseVariantAnnotationassociatedPD
PA165374673ticagrelorChemicalGuidelineAnnotation, LabelAnnotation, VariantAnnotationassociatedPD26151596
PA165816522CYP2C19*6HaplotypeLabelAnnotationassociated
PA165816523CYP2C19*7HaplotypeLabelAnnotationassociated
PA165816524CYP2C19*8HaplotypeLabelAnnotationassociated
PA165816533CYP2C19*17HaplotypeGuidelineAnnotation, VipGeneassociated11240980, 11452243, 12222994, 15168101, 16132042, 16772608, 16912869, 16961157, 17625515, 17645482, 17900275, 18004210, 18654768, 18677622, 18781853, 19106083, 19106084, 19108880, 19166419, 19496924, 19621685, 19884907, 20351750, 20376628, 20492469, 20531370, 20620727, 20665013, 20826260, 20890775, 21412232, 21511218, 21693476, 8563772, 8835703, 9316174, 9867757, 10340921
PA165816544CYP2C9*3HaplotypeGuidelineAnnotationassociated
PA165817016Kidney TransplantationDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD23175667, 29607533
PA165860521ambrisentanChemicalMultilinkAnnotation, VariantAnnotationassociatedPK25286744
PA165954769HLA-B*15:02:01HaplotypeLabelAnnotationassociated
PA165980634CYP2C19*1HaplotypeLabelAnnotationassociated
PA165980635CYP2C19*2HaplotypeGuidelineAnnotation, LabelAnnotation, VipGeneassociated11240980, 11452243, 12222994, 15168101, 16132042, 16772608, 16912869, 16961157, 17625515, 17645482, 17900275, 18004210, 18654768, 18677622, 18781853, 19106083, 19106084, 19108880, 19166419, 19496924, 19621685, 19884907, 20351750, 20376628, 20492469, 20531370, 20620727, 20665013, 20826260, 20890775, 21412232, 21511218, 21693476, 8563772, 8835703, 9316174, 9867757, 10340921
PA165980636CYP2C19*3HaplotypeLabelAnnotation, VipGeneassociated11240980, 11452243, 12222994, 15168101, 16132042, 16772608, 16912869, 16961157, 17625515, 17645482, 17900275, 18004210, 18654768, 18677622, 18781853, 19106083, 19106084, 19108880, 19166419, 19496924, 19621685, 19884907, 20351750, 20376628, 20492469, 20531370, 20620727, 20665013, 20826260, 20890775, 21412232, 21511218, 21693476, 8563772, 8835703, 9316174, 9867757, 10340921
PA165980637CYP2C19*4HaplotypeLabelAnnotationassociated
PA165980638CYP2C19*5HaplotypeLabelAnnotationassociated
PA166014703etravirineChemicalClinicalAnnotationassociatedPK23111422
PA166048740Helicobacter InfectionsDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD10579481, 11240980, 11446878, 11785712, 12121503, 12544691, 12662378, 12809821, 14638340, 15710002, 15952098, 15976989, 16815316, 16863547, 16912869, 17215846, 18637061, 19166419, 19552744, 20559522, 20633187, 21054464, 21118735, 21361732, 23646118, 27611887, 9867757
PA166048829Elderly AdultDiseaseVariantAnnotationnot associatedPK24858822
PA166110255lafutidineChemicalVariantAnnotationnot associatedPD12662378, 14653835
PA166110257dexlansoprazoleChemicalClinicalAnnotation, LabelAnnotationassociatedPK22455762
PA166114457lung transplantationDiseaseVariantAnnotationambiguousPD21038076, 26982740
PA166114460icotinibChemicalClinicalAnnotation, MultilinkAnnotation, VariantAnnotationassociatedPK22585284, 25995169
PA166118565ginkgo biloba extractChemicalLiterature, MultilinkAnnotationnot associated19299322
PA166122590simeprevirChemicalLabelAnnotationassociated
PA166122646hemopoietic stem cell transplantDiseaseClinicalAnnotation, VariantAnnotationassociatedPKPD24165757, 24192117, 26616742
PA166123007hematopoietic stem cell transplantationDiseaseVariantAnnotationambiguousPKPD19933691, 28685218
PA166123203intragastric phDiseaseVariantAnnotationassociatedPKPD21361732, 24996380
PA166123207overall survivalDiseaseVariantAnnotationassociatedPD21047200
PA166123366event-free survivalDiseaseVariantAnnotationassociatedPD23842856
PA166123368schizoaffective disorderDiseaseVariantAnnotationassociatedPKPD28664816
PA166123369electrocardiogram qt prolongedDiseaseVariantAnnotationassociatedPD
PA166123766platelet aggregationDiseaseVariantAnnotationassociatedPD28604225, 30020015
PA166124406platelet reactivityDiseaseVariantAnnotationambiguousPD24402637, 24856643, 25175362, 25828136, 25832119, 25850030, 25891840, 25897911, 27380588, 28329746, 28589365
PA166124478endoxifenChemicalVariantAnnotationnot associatedPK
PA166127651n-desmethyltamoxifenChemicalVariantAnnotationnot associatedPK
PA1661276524-hydroxytamoxifenChemicalVariantAnnotationnot associatedPK
PA166127658Recurrence free survivalDiseaseVariantAnnotationnot associatedPD19156902
PA166128095treatment failureDiseaseVariantAnnotationassociatedPD25986028, 29325448
PA166128206dipyroneChemicalClinicalAnnotationassociatedPK25241292
PA166128371platelet aggregation inhibitionDiseaseVariantAnnotationassociatedPD25115434, 28135763
PA166129537composite endpoints (transient ischemic attack (tia), stroke, myocardial infarction, or death)DiseaseVariantAnnotationambiguousPD
PA166129538secondary composite endpoints (transient ischemic attack (tia), stroke, or death)DiseaseVariantAnnotationassociatedPD
PA166129560major adverse cardiac events (mace)DiseaseVariantAnnotationambiguousPD27653892, 28377187, 29397568
PA166131507desmethyl clomipramineChemicalVariantAnnotationassociatedPK28470111
PA166151827adverse eventsDiseaseVariantAnnotationassociatedPD
PA166152940tolperisoneChemicalVariantAnnotationnot associatedPK25953735
PA166153431flibanserinChemicalLabelAnnotationassociated
PA166153491brivaracetamChemicalClinicalAnnotation, LabelAnnotation, VariantAnnotationassociatedPK24717838
PA166154053rs4244285VariantVipGeneassociated11240980, 11452243, 12222994, 15168101, 16132042, 16772608, 16912869, 16961157, 17625515, 17645482, 17900275, 18004210, 18654768, 18677622, 18781853, 19106083, 19106084, 19108880, 19166419, 19496924, 19621685, 19884907, 20351750, 20376628, 20492469, 20531370, 20620727, 20665013, 20826260, 20890775, 21412232, 21511218, 21693476, 8563772, 8835703, 9316174, 9867757, 10340921
PA166154070rs4986893VariantVipGeneassociated11240980, 11452243, 12222994, 15168101, 16132042, 16772608, 16912869, 16961157, 17625515, 17645482, 17900275, 18004210, 18654768, 18677622, 18781853, 19106083, 19106084, 19108880, 19166419, 19496924, 19621685, 19884907, 20351750, 20376628, 20492469, 20531370, 20620727, 20665013, 20826260, 20890775, 21412232, 21511218, 21693476, 8563772, 8835703, 9316174, 9867757, 10340921
PA166154147rs12248560VariantVipGeneassociated11240980, 11452243, 12222994, 15168101, 16132042, 16772608, 16912869, 16961157, 17625515, 17645482, 17900275, 18004210, 18654768, 18677622, 18781853, 19106083, 19106084, 19108880, 19166419, 19496924, 19621685, 19884907, 20351750, 20376628, 20492469, 20531370, 20620727, 20665013, 20826260, 20890775, 21412232, 21511218, 21693476, 8563772, 8835703, 9316174, 9867757, 10340921
PA166160048lacosamideChemicalLabelAnnotationassociated
PA166163418rucaparibChemicalLabelAnnotationassociated
PA166163563high on-treatment platelet reactivityDiseaseVariantAnnotationambiguousPD29397568
PA166163659n-desmethylclozapineChemicalVariantAnnotationassociatedPK28664816
PA166163794composite endpoints (stroke, myocardial infarction, or vascular death)DiseaseVariantAnnotationassociatedPD27806998
PA166165020adverse cardiovascular eventsDiseaseVariantAnnotationambiguousPD28329746, 28589365
PA166180939phenazepamChemicalClinicalAnnotationassociatedPD30325732
PA193HTR2AGeneDataAnnotationassociated
PA27093CYP1A2GeneDataAnnotationassociated
PA312SLC6A4GeneDataAnnotationassociated
PA443309AlcoholismDiseaseClinicalAnnotationassociatedPD30325732
PA443362Angina PectorisDiseaseVariantAnnotationambiguousPD23993903, 24019397
PA443423Arterial Occlusive DiseasesDiseaseVariantAnnotationassociatedPD
PA443450AsthmaDiseaseVariantAnnotationassociated23623526
PA443459Atrial FibrillationDiseaseClinicalAnnotation, VariantAnnotationassociatedPD27356304
PA443560Breast NeoplasmsDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD19156902, 20179710, 21047200, 21480951, 21830868, 21961651, 23842856, 24682508, 26799162, 29938344, 30022682
PA443626Carcinoma, Squamous CellDiseaseVariantAnnotationassociatedPD26982740
PA443635Cardiovascular DiseasesDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD16772608, 17697139, 17900275, 18004210, 18323861, 18346178, 18394438, 18482659, 18532997, 18577829, 18781853, 19106083, 19106084, 19108880, 19193675, 19268736, 19463375, 19531897, 19576320, 19624462, 19926050, 19934793, 20351750, 20492469, 20510210, 20620727, 20650435, 20708365, 20724801, 20801498, 20833683, 20845077, 20924183, 20965456, 20979470, 21075428, 21099121, 21163112, 21168310, 21178986, 21527445, 21628721, 21700758, 21806387, 21831410, 21918510, 21972404, 22028352, 22088980, 22228204, 22285300, 22390861, 22462746, 22624833, 22940005, 22990067, 23364775, 23993903, 24782221, 25712182, 25730082, 25851472, 25860557, 25897911, 26265231, 28589365, 28806186, 29723426, 30983508
PA443636Carotid Artery DiseasesDiseaseVariantAnnotationambiguousPD26526111
PA443672Ischemic Attack, TransientDiseaseVariantAnnotationambiguousPD26265231, 27806998
PA443678Cerebrovascular DisordersDiseaseVariantAnnotationassociatedPD
PA443796Coronary Artery DiseaseDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD18323861, 18346178, 18532997, 19106083, 19106084, 19463375, 19576320, 20083681, 20492469, 20650435, 20724801, 20801498, 20826260, 21075428, 21168310, 21178986, 21716274, 22028352, 22045970, 22123356, 22228204, 22374717, 22462746, 22704413, 22955794, 22974728, 22990067, 23001453, 23150151, 23364775, 23402725, 23428009, 23429358, 23640828, 23692149, 23726091, 23922007, 24019397, 24080325, 24088578, 24214141, 24402637, 24504666, 24508947, 24535487, 24576527, 24608794, 24781308, 24821368, 24996381, 25008027, 25877345, 26071277, 26311225, 27450232, 28589365, 29397568
PA443797Coronary DiseaseDiseaseVariantAnnotationassociatedPD24535487, 24608794, 25891840
PA443829Cystic FibrosisDiseaseVariantAnnotationambiguousPD21038076
PA443842DeathDiseaseVariantAnnotationambiguousPD19106084, 22527345, 25877345, 26265231
PA443886Diabetes MellitusDiseaseVariantAnnotationassociatedPD28664816
PA443937Drug ToxicityDiseaseVariantAnnotationambiguousPD15590749, 18466100, 21038076, 21831685, 28685218
PA444065EpilepsyDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD12451290, 14729419, 15483195, 15533655, 18466100, 23666564, 24345815, 25162219, 25323806, 26223287
PA444086Erythema NodosumDiseaseVariantAnnotationassociatedPD31124417
PA444104EsophagitisDiseaseClinicalAnnotationassociatedPKPD10340921, 10982760, 11069321, 14653835, 15447734, 17112810, 21361732, 24996380
PA444255Gastroesophageal RefluxDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD10340921, 10982760, 11012469, 11069321, 11380317, 11446878, 11785712, 11929404, 12121503, 12386647, 12544691, 12656699, 14638340, 14653835, 14687173, 15447734, 15470328, 15903128, 15932363, 15963082, 16338278, 16815316, 16863547, 16911688, 17112810, 17295875, 17725594, 17934830, 19166419, 19259653, 20633187, 21054464, 21361732, 22324425, 24996380, 29377228
PA444327Granulomatous Disease, ChronicDiseaseVariantAnnotationassociatedPK23215888
PA444339HallucinationsDiseaseVariantAnnotationassociatedPD
PA444395Hematologic DiseasesDiseaseVariantAnnotationambiguousPKPD
PA444417HemorrhageDiseaseClinicalAnnotation, VariantAnnotationambiguousPD22123356, 27348249, 27806998, 28329746, 29260275
PA444445Hepatitis CDiseaseVariantAnnotationassociatedPK25155930
PA444516HypercholesterolemiaDiseaseVariantAnnotationnot associatedPK23930675
PA444545HyperprolactinemiaDiseaseVariantAnnotationassociatedPK25025989
PA444614InfectionDiseaseVariantAnnotationnot associatedPK
PA444620InflammationDiseaseVariantAnnotationnot associatedPD26311225
PA444745LeprosyDiseaseVariantAnnotationassociatedPD31124417
PA444773LeukopeniaDiseaseVariantAnnotationnot associatedPD26894931
PA444822Lupus Erythematosus, SystemicDiseaseClinicalAnnotationassociatedPKPD20358205
PA444840LymphomaDiseaseVariantAnnotationassociatedPK25155930
PA444845Lymphoma, Non-HodgkinDiseaseVariantAnnotationassociatedPKPD28181240
PA444859MalariaDiseaseVariantAnnotationassociatedPK10471063
PA445009MycosesDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD15179414, 16003289, 16890574, 17827141, 18982321, 19033450, 19261446, 19299322, 19933691, 21038076, 21192313, 21383338, 21507170, 21831685, 23215888, 23588332, 24554646, 25155930, 25239277, 25558073, 25986028, 26024717, 26239729, 26616742, 26775563, 26861072, 27056297, 27143031, 27284960, 27388292, 27432796, 27937048, 28685218, 28834922, 29285995, 29393850, 29607533
PA445019Myocardial InfarctionDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD19106083, 19463375, 20083681, 20492469, 20801498, 20826260, 22028352, 22045970, 22228204, 22462746, 22704413, 22955794, 22990067, 23364775, 23726091, 23922007, 24019397, 24080325, 25850030, 25877345, 26265231, 26556524, 27767438, 28604225, 29260275
PA445043Opioid-Related DisordersDiseaseVariantAnnotationnot associatedPK17178267
PA445105Neurologic ManifestationsDiseaseVariantAnnotationassociatedPD25042870
PA445218Pancreatic NeoplasmsDiseaseClinicalAnnotation, VariantAnnotationassociatedPK16267764, 25752914
PA445506RecurrenceDiseaseVariantAnnotationambiguousPD24682508, 27767438, 30022682
PA445526Respiratory Tract InfectionsDiseaseVariantAnnotationassociated23623526
PA445647Shock, SepticDiseaseVariantAnnotationassociatedPK25155930
PA445850ThrombosisDiseaseClinicalAnnotation, Literature, MultilinkAnnotation, VariantAnnotationambiguousPKPD16772608, 17697139, 17900275, 18004210, 18323861, 18346178, 18394438, 18482659, 18532997, 18577829, 18781853, 19106083, 19106084, 19108880, 19193675, 19268736, 19463375, 19531897, 19576320, 19624462, 19926050, 19934793, 20351750, 20492469, 20510210, 20620727, 20650435, 20708365, 20724801, 20801498, 20833683, 20845077, 20877456, 20924183, 20979470, 21099121, 21163112, 21168310, 21178986, 21527445, 21628721, 21700758, 21806387, 21831410, 21918510, 21972404, 22028352, 22088980, 22228204, 22285300, 22462746, 22624833, 22940005, 22990067, 23364775, 24508947, 25730082, 25860557, 26265231, 28589365, 28806186, 30191759
PA445876Tobacco Use DisorderDiseaseVariantAnnotationnot associatedPD
PA445941TuberculosisDiseaseClinicalAnnotationassociatedPD
PA445973UlcerDiseaseVariantAnnotationambiguousPD10982760, 17645482, 17934830
PA446023VasculitisDiseaseVariantAnnotationnot associatedPD26894931
PA446065Wegener GranulomatosisDiseaseVariantAnnotationnot associatedPD26894931
PA446155Precursor Cell Lymphoblastic Leukemia-LymphomaDiseaseVariantAnnotationassociatedPD27143031
PA446336Severe Combined ImmunodeficiencyDiseaseVariantAnnotationassociatedPK27056297
PA446459Myocardial IschemiaDiseaseVariantAnnotationambiguousPD22955794
PA447054StrokeDiseaseMultilinkAnnotation, VariantAnnotationambiguousPD25529343, 25877345, 26019129, 26265231, 26873108, 27233747, 27806998, 29520080
PA447198Autistic DisorderDiseaseVariantAnnotationnot associatedPD
PA447199Bipolar DisorderDiseaseVariantAnnotationnot associatedPD27353638
PA447207Depressive DisorderDiseaseVariantAnnotationassociatedPK19773541, 19884907
PA447208Mental DisordersDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD11763000, 12172336, 15205367, 16044105, 16413245, 17625515, 18677622, 20531370
PA447211Obsessive-Compulsive DisorderDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD23332809, 23357843, 23545896, 27804107
PA447212Panic DisorderDiseaseVariantAnnotationassociatedPD28614176
PA447215Psychotic DisordersDiseaseVariantAnnotationnot associatedPD27353638
PA447216SchizophreniaDiseaseVariantAnnotationassociatedPKPD28664816
PA447230HIVDiseaseClinicalAnnotationassociatedPK16267764, 21860339, 23111422, 25752914
PA447240Peptic UlcerDiseaseClinicalAnnotation, VariantAnnotationassociatedPKPD10340921, 10982760, 11069321, 14653835, 15447734, 17112810, 21361732, 23267857, 24996380
PA447278DepressionDiseaseClinicalAnnotation, DataAnnotation, VariantAnnotationambiguousPKPD20468063, 23332809, 23357843, 23545896, 23799451, 27800629, 28480819, 30983508
PA447300Acquired Long QT Syndrome (aLQTS)DiseaseVariantAnnotationnot associatedPD30983508
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotation, DataAnnotation, VariantAnnotationambiguousPKPD10510155, 11452243, 11802100, 12975335, 15168101, 15590749, 16236141, 16418702, 16855453, 17625515, 17667959, 18654768, 18677622, 19404631, 19593158, 19773541, 19840783, 1988236, 19884907, 20350136, 20531370, 21926427, 23545896, 23981149, 24014145, 24257813, 24858822, 25122046, 25154506, 26343256, 26830411, 30135031, 7965806, 8451774, 8835703, 8835706, 9316174
PA447325Coronary RestenosisDiseaseVariantAnnotationassociatedPD27464309
PA448385amitriptylineChemicalClinicalAnnotation, GuidelineAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGeneambiguousPKPD12222994, 15168101, 16413245, 17625515, 18677622, 19884907, 20083681, 20492469, 20531370, 21412232, 7969038, 8195181, 8563772, 8835703, 9316174, 11452243, 12012142, 12172336, 15168101, 15205367, 15590749, 16024198, 16044105, 20531370, 23486447
PA448497aspirinChemicalClinicalAnnotation, VariantAnnotationambiguousPKPD20833683, 20965456, 21075428, 21345843, 21511217, 22390861, 23993903, 24336898, 24576527, 25712182, 26311225, 27348249, 28589365, 28604225, 29520080, 29723426, 30020015, 30191759
PA448500atorvastatinChemicalPathway, VariantAnnotationassociated24140730
PA448687bupropionChemicalClinicalAnnotation, Literature, MultilinkAnnotation, VariantAnnotationambiguousPKPD25187485
PA448691busulfanChemicalClinicalAnnotationassociatedPK24165757, 24192117
PA448785carbamazepineChemicalVipGeneassociated
PA448809carisoprodolChemicalClinicalAnnotation, LabelAnnotation, VariantAnnotationambiguousPKPD16021435, 22527345
PA448817carvedilolChemicalVariantAnnotationnot associatedPK21599570
PA448871celecoxibChemicalVariantAnnotationnot associatedPK21692664
PA448927chloramphenicolChemicalVipGeneassociated
PA449001cimetidineChemicalVipGeneassociated
PA449015citalopramChemicalClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Pathway, VariantAnnotation, VipGeneambiguousPKPD12222994, 15168101, 16413245, 17625515, 18677622, 19884907, 20083681, 20492469, 20531370, 21412232, 7969038, 8195181, 8563772, 8835703, 9316174, 11452243, 11802100, 12975335, 15168101, 16418702, 16855453, 17625515, 18654768, 19404631, 19593158, 19773541, 19840783, 20350136, 20531370, 21546862, 21926427, 23545896, 23981149, 24014145, 24257813, 24858822, 25122046, 25154506, 26343256, 27804107, 30135031, 30983508, 8451774, 8835706
PA449048clomipramineChemicalClinicalAnnotation, GuidelineAnnotation, Literature, MultilinkAnnotation, Pathway, VariantAnnotation, VipGeneambiguousPKPD12222994, 15168101, 16413245, 17625515, 18677622, 19884907, 20083681, 20492469, 20531370, 21412232, 7969038, 8195181, 8563772, 8835703, 9316174, 11452243, 11763000, 20531370, 23486447, 23545896, 27800629, 28470111
PA449053clopidogrelChemicalClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, Pathway, VariantAnnotation, VipGeneambiguousPKPD15199661, 15258107, 16132042, 16413245, 16772608, 17625515, 17900275, 18004210, 18781853, 19106083, 19106084, 19108880, 19496924, 20083681, 20351750, 20492469, 20620727, 20665013, 20826260, 20890775, 21412232, 21511218, 21693476, 7969038, 8148870, 8195181, 8563772, 12222994, 16772608, 17697139, 17900275, 18004210, 18323861, 18346178, 18394438, 18482659, 18532997, 18577829, 18781853, 19106083, 19106084, 19108880, 19193675, 19268736, 19463375, 19531897, 19576320, 19624462, 19926050, 19934793, 20083681, 20351750, 20492469, 20510210, 20620727, 20650435, 20708365, 20724801, 20801498, 20826260, 20833683, 20845077, 20877456, 20924183, 20938371, 20965456, 20979470, 21075428, 21099121, 21163112, 21168310, 21178986, 21345843, 21352268, 21511217, 21527445, 21628721, 21700758, 21716271, 21716274, 21806387, 21831410, 21918510, 21972404, 22028352, 22045970, 22088980, 22123356, 22228204, 22285300, 22374717, 22390861, 22462746, 22464343, 22624833, 22704413, 22940005, 22955794, 22974728, 22990067, 23001453, 23150151, 23364775, 23402725, 23428009, 23429358, 23470885, 23517020, 23556336, 23640828, 23692149, 23698643, 23726091, 23895809, 23922007, 23993903, 24019397, 24080325, 24088578, 24140730, 24214141, 24262617, 24336898, 24402637, 24418943, 24479687, 24504666, 24508947, 24535487, 24576527, 24608794, 24624918, 24632932, 24781308, 24782221, 24821368, 24856643, 24945780, 24951432, 24996381, 25001882, 25008027, 25115434, 25175362, 25258374, 25329996, 25529343, 25542807, 25712182, 25730082, 25828136, 25832119, 25850030, 25851472, 25860557, 25877345, 25891840, 25897911, 26071277, 26151596, 26265231, 26311225, 26362473, 26369612, 26526111, 26556524, 26873108, 27023676, 27233747, 27348249, 27380588, 27450232, 27464309, 27653892, 27767438, 27806998, 28135763, 28329746, 28377187, 28589365, 28604225, 28806186, 29260275, 29397568, 29520080, 29723426, 30020015, 30191759
PA449061clozapineChemicalVariantAnnotationassociatedPD28664816
PA449165cyclophosphamideChemicalClinicalAnnotation, VariantAnnotationambiguousPKPD20179710, 20358205, 26894931, 28181240, 29938344
PA449233desipramineChemicalPathway, VariantAnnotationambiguousPK17667959
PA449283diazepamChemicalClinicalAnnotation, LabelAnnotation, MultilinkAnnotation, Pathway, VariantAnnotationambiguousPK16338280, 27099220
PA449409doxepinChemicalClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, Pathway, VariantAnnotationassociatedPK12360109, 23486447
PA449412doxorubicinChemicalClinicalAnnotationassociatedPD20179710, 29938344
PA449441efavirenzChemicalVariantAnnotationassociatedPK
PA449586famotidineChemicalVariantAnnotationambiguousPKPD11929404, 15710002, 15903128, 15963082, 17112810
PA449590felbamateChemicalVipGeneassociated
PA449653fluconazoleChemicalVariantAnnotationnot associatedPK21692664
PA449673fluoxetineChemicalPathway, VariantAnnotationambiguousPKPD16236141, 21692664, 23545896, 28494448
PA449688fluvastatinChemicalPathwayassociated
PA449690fluvoxamineChemicalGuidelineAnnotation, VariantAnnotation, VipGeneambiguousPKPD21692664, 23545896
PA449918hydromorphoneChemicalVariantAnnotationnot associatedPK
PA449957ibuprofenChemicalPathwayassociated25502615
PA449969imipramineChemicalClinicalAnnotation, GuidelineAnnotation, Literature, MultilinkAnnotation, Pathway, VariantAnnotation, VipGeneambiguousPKPD12222994, 15168101, 16413245, 17625515, 18677622, 19884907, 20083681, 20492469, 20531370, 21412232, 7969038, 8195181, 8563772, 8835703, 9316174, 11452243, 17667959, 1988236, 19884907, 23486447, 7965806, 8835703, 9316174
PA449982indomethacinChemicalVipGeneassociated
PA450112isoniazidChemicalClinicalAnnotation, VipGeneassociatedPD
PA450146ketoconazoleChemicalVariantAnnotationnot associatedPK21692664
PA450180lansoprazoleChemicalClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotation, VipGeneambiguousPKPD11240980, 12222994, 16413245, 16912869, 16961157, 17625515, 17645482, 18654768, 19166419, 19621685, 20083681, 20376628, 20492469, 7969038, 8195181, 8563772, 9867757, 10340921, 11012469, 11240980, 11474773, 11929404, 12121503, 12386647, 12544691, 12656699, 12662378, 14638340, 15710002, 15952098, 15963082, 16815316, 16863547, 17215846, 17295875, 19166419, 19259653, 22076562, 23623526, 24996380, 9164419, 9272410
PA450272lovastatinChemicalPathwayassociated
PA450373mephenytoinChemicalClinicalAnnotation, VariantAnnotation, VipGeneambiguousPKPD15258107, 16772608, 21412232, 8148870, 8195181, 10022751, 10411572, 12464799, 15199661, 16413245, 17455109, 19661214, 21325430, 25001882, 26153442, 27578295, 7969038, 8195181, 8747407, 8988068, 9103550, 9435198, 9732415
PA450374methylphenobarbitalChemicalClinicalAnnotation, VariantAnnotationassociatedPK15499191
PA450401methadoneChemicalVariantAnnotationambiguousPK17178267, 27199033
PA450480metoprololChemicalVariantAnnotationnot associatedPK15467211
PA450522mirtazapineChemicalGuidelineAnnotation, VariantAnnotationambiguousPD23545896
PA450530modafinilChemicalVipGeneassociated
PA450606nelfinavirChemicalClinicalAnnotation, LabelAnnotation, MultilinkAnnotation, VariantAnnotationassociatedPK16267764, 25752914
PA450616nevirapineChemicalClinicalAnnotationassociatedPK21860339
PA450651norethindroneChemicalVipGeneassociated
PA450657nortriptylineChemicalVariantAnnotationambiguousPK12012142, 15205367, 20531370
PA450704omeprazoleChemicalClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGeneambiguousPKPD11240980, 12222994, 16413245, 16912869, 16961157, 17625515, 17645482, 18654768, 19166419, 19621685, 20083681, 20376628, 20492469, 7969038, 8195181, 8563772, 9867757, 10206083, 10340921, 10511062, 10579481, 10626755, 10982760, 11046127, 11069321, 11240980, 11446878, 11474773, 11785712, 12121503, 12809821, 14638340, 14653835, 1505152, 15447734, 15932363, 15976989, 16815316, 16863547, 17112810, 17934830, 18312490, 18637061, 18751689, 19166419, 19661214, 20633187, 21054464, 21118735, 21325430, 21352268, 21361732, 21692664, 24945780, 24996380, 25495411, 26153442, 26244421, 27578295, 29377228, 7648764, 8675169, 8681489, 8747407, 8823231, 9014204, 9284848, 9357389, 9797796, 9829356, 9867757
PA450731oxazepamChemicalPathwayassociated
PA450774pantoprazoleChemicalClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotation, VipGeneambiguousPKPD11240974, 15976989, 16912869, 17645482, 18637061, 18664620, 19166419, 19785625, 25495411, 27611887, 9433390
PA450801paroxetineChemicalPathway, VariantAnnotationambiguousPD23545896
PA450911phenobarbitalChemicalVariantAnnotationassociatedPD23551241
PA450921phenprocoumonChemicalVariantAnnotationassociatedPD21636598
PA450947phenytoinChemicalClinicalAnnotation, DataAnnotation, LabelAnnotation, Pathway, VariantAnnotationambiguousPKPD22569204, 23551241, 25162219, 25597548, 28391407
PA451100prednisoneChemicalVipGeneassociated
PA451123progesteroneChemicalClinicalAnnotationassociatedPK31482508
PA451124proguanilChemicalVariantAnnotationassociatedPK10471063
PA451182pyrazinamideChemicalClinicalAnnotationassociatedPD
PA451201quetiapineChemicalVariantAnnotationassociatedPK25025989
PA451216rabeprazoleChemicalClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotationambiguousPKPD11012469, 11380317, 11446878, 11474773, 11785712, 12121503, 12544691, 14638340, 14687173, 15470328, 15903128, 16815316, 16863547, 16911688, 17725594, 17934830, 19166419, 19552744, 20559522, 20633187, 21054464, 21118735, 22324425, 23646118, 24996380, 25495411, 7648764
PA451250rifampinChemicalClinicalAnnotation, VipGeneassociatedPD
PA451257risperidoneChemicalVariantAnnotationassociatedPD25042870
PA451333sertralineChemicalClinicalAnnotation, GuidelineAnnotation, MultilinkAnnotation, VariantAnnotation, VipGeneambiguousPKPD12222994, 15168101, 16413245, 17625515, 18677622, 19884907, 20083681, 20492469, 20531370, 21412232, 7969038, 8195181, 8563772, 8835703, 9316174, 10510155, 11452243, 15168101, 18677622, 21692664, 23545896, 25974703, 26830411, 30983508
PA451363simvastatinChemicalPathwayassociated
PA451578tacrolimusChemicalClinicalAnnotation, VariantAnnotationambiguousPD23175667
PA451581tamoxifenChemicalClinicalAnnotation, Pathway, VariantAnnotationambiguousPKPD19156902, 21047200, 21480951, 21830868, 21961651, 23842856, 23962908, 24682508, 26799162, 30022682
PA451608temazepamChemicalPathwayassociated
PA451644thalidomideChemicalVariantAnnotationassociatedPD31124417
PA451686ticlopidineChemicalVariantAnnotation, VipGeneambiguousPK21692664
PA451718tolbutamideChemicalVariantAnnotationassociatedPK10022751, 10411572
PA451728topiramateChemicalVipGeneassociated
PA451741tranylcypromineChemicalVariantAnnotationnot associatedPK21692664
PA451791trimipramineChemicalClinicalAnnotation, GuidelineAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGeneassociatedPK12222994, 15168101, 16413245, 17625515, 18677622, 19884907, 20083681, 20492469, 20531370, 21412232, 7969038, 8195181, 8563772, 8835703, 9316174, 10774635, 11452243, 14520122, 23486447
PA451799troglitazoneChemicalVariantAnnotationnot associatedPK21692664
PA451846valproic acidChemicalClinicalAnnotation, VariantAnnotationambiguousPKPD26223287, 27353638
PA451866venlafaxineChemicalClinicalAnnotation, VariantAnnotationambiguousPKPD23332809, 23357843, 23545896, 23799451, 28480819
PA451906warfarinChemicalClinicalAnnotation, MultilinkAnnotation, VariantAnnotationassociatedPKPD18574025, 19752777, 21692828, 23941071, 25652102, 27356304, 8723744
PA452229antidepressantsChemicalGuidelineAnnotation, MultilinkAnnotation, VariantAnnotation, VipGeneassociatedPK15258107, 16772608, 21412232, 8148870, 8195181, 15168101, 15199661, 27023676
PA452615moclobemideChemicalGuidelineAnnotation, LabelAnnotationassociated
PA452621antineoplastic agentsChemicalVariantAnnotationambiguousPD19156902, 23842856, 24682508
PA452632acenocoumarolChemicalVariantAnnotationambiguousPD21636598, 23651023

References

Pubmed IDYearTitleCitations
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191060842009Cytochrome p-450 polymorphisms and response to clopidogrel.391
197068582009Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.307
197068582009Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.307
191060832009Genetic determinants of response to clopidogrel and cardiovascular events.288
191060832009Genetic determinants of response to clopidogrel and cardiovascular events.288
209782602010Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis.204
167726082006Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects.155
167726082006Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects.155
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Citation

Dessen P

CYP2C19 (cytochrome P450 family 2 subfamily C member 19)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40243/cyp2c19