Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1558
MIM: 601129
HGNC: 2622
Ensembl: ENSG00000138115
Variants:
dbSNP: 1558
ClinVar: 1558
TCGA: ENSG00000138115
COSMIC: CYP2C8
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10235 | zoledronate | Chemical | ClinicalAnnotation | associated | PD | 18594024 | |
| PA128406954 | Weight gain | Disease | VariantAnnotation | ambiguous | PD | 27271184 | |
| PA128406956 | fluorouracil | Chemical | ClinicalAnnotation | associated | PD | ||
| PA133950441 | hmg coa reductase inhibitors | Chemical | Pathway | associated | |||
| PA164712563 | Bisphosphonates | Chemical | ClinicalAnnotation, VariantAnnotation, VipGene | ambiguous | PD | 21396799, 18594024 | |
| PA164712580 | Calcineurin inhibitors | Chemical | VariantAnnotation | associated | PD | 23426640 | |
| PA164746311 | everolimus | Chemical | VariantAnnotation | not associated | PD | 23797529 | |
| PA164748728 | mycophenolic acid | Chemical | Pathway, VipGene | associated | 22572835, 24220207 | ||
| PA164925725 | Toxic liver disease | Disease | VariantAnnotation | ambiguous | PD | 17241877, 25504632 | |
| PA165291492 | pazopanib | Chemical | VariantAnnotation | associated | PD | 25504632 | |
| PA165817016 | Kidney Transplantation | Disease | ClinicalAnnotation, VariantAnnotation | associated | PK | PD | 18769365, 23426640, 24681964, 28316087 |
| PA165958682 | CYP2C8*1B | Haplotype | VipGene | associated | 17923851, 12429347 | ||
| PA165958683 | CYP2C8*1C | Haplotype | VipGene | associated | 12429347 | ||
| PA165958684 | CYP2C8*2 | Haplotype | VipGene | associated | 17361129, 20459297, 23536207, 11668219 | ||
| PA165958685 | CYP2C8*3 | Haplotype | VipGene | associated | 11767116, 12429347, 12435384, 12530467, 12756196, 15655291, 15900280, 16164496, 17361129, 17923851, 19614891, 20421446, 20459297, 20665013, 23536207, 11668219 | ||
| PA165958686 | CYP2C8*4 | Haplotype | VipGene | associated | 17923851, 18574320, 20459297, 20848147, 23536207, 12429347 | ||
| PA166114458 | heart transplantation | Disease | VariantAnnotation | not associated | PD | 23797529 | |
| PA166122590 | simeprevir | Chemical | LabelAnnotation | associated | |||
| PA166131631 | glomerular filtration rate | Disease | VariantAnnotation | associated | 28316087 | ||
| PA166153431 | flibanserin | Chemical | LabelAnnotation | associated | |||
| PA166153961 | rs1058930 | Variant | VipGene | associated | 17923851, 18574320, 20459297, 20848147, 23536207, 12429347 | ||
| PA166154085 | rs7909236 | Variant | VipGene | associated | 17923851, 12429347 | ||
| PA166154110 | rs10509681 | Variant | VipGene | associated | 11767116, 12429347, 12435384, 12530467, 12756196, 15655291, 15900280, 16164496, 17361129, 17923851, 19614891, 20421446, 20459297, 20665013, 23536207, 11668219 | ||
| PA166154140 | rs11572080 | Variant | VipGene | associated | 11767116, 12429347, 12435384, 12530467, 12756196, 15655291, 15900280, 16164496, 17361129, 17923851, 19614891, 20421446, 20459297, 20665013, 23536207, 11668219 | ||
| PA166154141 | rs11572103 | Variant | VipGene | associated | 17361129, 20459297, 23536207, 11668219 | ||
| PA166154160 | rs17110453 | Variant | VipGene | associated | 12429347 | ||
| PA166163418 | rucaparib | Chemical | LabelAnnotation | associated | |||
| PA166163692 | diclofenac acyl glucuronide | Chemical | VariantAnnotation | associated | PK | 29203276 | |
| PA378 | NR1I2 | Gene | Pathway | associated | 21151855 | ||
| PA443450 | Asthma | Disease | ClinicalAnnotation | associated | PK | 28940478 | |
| PA443560 | Breast Neoplasms | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PK | PD | 24599932, 25495407, 30520341 |
| PA443622 | Carcinoma, Non-Small-Cell Lung | Disease | ClinicalAnnotation | associated | PD | 31616045 | |
| PA443886 | Diabetes Mellitus | Disease | VariantAnnotation | ambiguous | PD | 27271184 | |
| PA443937 | Drug Toxicity | Disease | ClinicalAnnotation | associated | PD | 20212519 | |
| PA444682 | Kidney Diseases | Disease | VariantAnnotation | ambiguous | PD | ||
| PA444985 | Multiple Myeloma | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 18594024 | |
| PA445113 | Neutropenia | Disease | ClinicalAnnotation | associated | PD | ||
| PA445187 | Osteonecrosis | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 18594024 | |
| PA445204 | Ovarian Neoplasms | Disease | VariantAnnotation | ambiguous | PK | PD | 20368717, 21327421 |
| PA445301 | Peripheral Nervous System Diseases | Disease | VariantAnnotation | ambiguous | PD | 24599932, 26115084 | |
| PA445846 | Thrombocytopenia | Disease | ClinicalAnnotation | associated | PD | 31616045 | |
| PA446975 | Neurotoxicity Syndromes | Disease | ClinicalAnnotation | associated | PD | 20212519 | |
| PA447247 | liver transplantation | Disease | VariantAnnotation | ambiguous | PD | ||
| PA448404 | amodiaquine | Chemical | ClinicalAnnotation, Pathway, VariantAnnotation, VipGene | associated | PK | PD | 21998472, 23204183, 17361129, 18855526 |
| PA448500 | atorvastatin | Chemical | Pathway | associated | |||
| PA448785 | carbamazepine | Chemical | Pathway | associated | 21738081 | ||
| PA448803 | carboplatin | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 21327421, 31616045 | |
| PA448871 | celecoxib | Chemical | VariantAnnotation | not associated | PK | 23996211 | |
| PA448897 | cerivastatin | Chemical | VariantAnnotation, VipGene | associated | PK | 15365880, 11844864 | |
| PA449053 | clopidogrel | Chemical | Literature, MultilinkAnnotation | associated | 24971633 | ||
| PA449165 | cyclophosphamide | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 24599932 | |
| PA449167 | cyclosporine | Chemical | VariantAnnotation | ambiguous | PD | 23426640 | |
| PA449293 | diclofenac | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PK | PD | 17241877, 18548238, 29203276 |
| PA449412 | doxorubicin | Chemical | VariantAnnotation | not associated | PD | ||
| PA449476 | epirubicin | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 24599932 | |
| PA449688 | fluvastatin | Chemical | Pathway | associated | |||
| PA449748 | gemcitabine | Chemical | ClinicalAnnotation | associated | PD | 31616045 | |
| PA449957 | ibuprofen | Chemical | ClinicalAnnotation, Pathway, VariantAnnotation, VipGene | associated | PK | PD | 18216720, 18694831, 19480553, 15289789, 18694831, 19480553, 25502615, 26122864, 30562214 |
| PA450272 | lovastatin | Chemical | Pathway | associated | |||
| PA450546 | montelukast | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PK | 28940478 | |
| PA450566 | mycophenolate mofetil | Chemical | ClinicalAnnotation | associated | PD | 24681964 | |
| PA450761 | paclitaxel | Chemical | ClinicalAnnotation, Pathway, VariantAnnotation, VipGene | ambiguous | PK | PD | 17224914, 17925548, 19143748, 20212519, 20368717, 22527201, 23215890, 11668219, 11767116, 12429347, 16299241, 18574320, 20212519, 20368717, 21151855, 21327421, 24599932, 25495407, 25504632, 26115084, 30520341 |
| PA450767 | pamidronate | Chemical | ClinicalAnnotation | associated | PD | 18594024 | |
| PA450970 | pioglitazone | Chemical | ClinicalAnnotation, VariantAnnotation, VipGene | ambiguous | PK | PD | 17913194, 23370354, 17178266, 22625877, 23712614, 27271184 |
| PA451234 | repaglinide | Chemical | ClinicalAnnotation, Pathway, VariantAnnotation, VipGene | associated | PK | PD | 15961978, 18388877, 21270106, 14534525, 17923851 |
| PA451283 | rosiglitazone | Chemical | ClinicalAnnotation, Pathway, VariantAnnotation, VipGene | associated | PK | PD | 23426382, 17178266, 23426382, 27271184 |
| PA451363 | simvastatin | Chemical | Pathway, VariantAnnotation | associated | PD | 25504632 | |
| PA451578 | tacrolimus | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PK | PD | 18769365, 23426640, 28316087 |
| PA7000 | sorafenib | Chemical | Pathway | associated | 28362716 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36178950 | 2023 | CYP2D6 and CYP2C8 pharmacogenetics and pharmacological interactions to predict imatinib plasmatic exposure in GIST patients. | 4 |
| 36587509 | 2023 | CYP2C8 and CYP2J2 gene variations increase the risk of hypertensive intracerebral hemorrhage. | 0 |
| 37175734 | 2023 | Functional Characterization of Allelic Variations of Human Cytochrome P450 2C8 (V181I, I244V, I331T, and L361F). | 1 |
| 37686184 | 2023 | Potential Association of Cytochrome P450 Copy Number Alteration in Tumour with Chemotherapy Resistance in Lung Adenocarcinoma Patients. | 1 |
| 36178950 | 2023 | CYP2D6 and CYP2C8 pharmacogenetics and pharmacological interactions to predict imatinib plasmatic exposure in GIST patients. | 4 |
| 36587509 | 2023 | CYP2C8 and CYP2J2 gene variations increase the risk of hypertensive intracerebral hemorrhage. | 0 |
| 37175734 | 2023 | Functional Characterization of Allelic Variations of Human Cytochrome P450 2C8 (V181I, I244V, I331T, and L361F). | 1 |
| 37686184 | 2023 | Potential Association of Cytochrome P450 Copy Number Alteration in Tumour with Chemotherapy Resistance in Lung Adenocarcinoma Patients. | 1 |
| 33976432 | 2022 | The anti-inflammatory role of placental Hofbauer cells is altered in patients with chorioamnionitis: Are CYP2C8 and soluble epoxide hydrolase involved in immunomodulation? | 0 |
| 34448113 | 2022 | Variability of CYP2C8 Polymorphisms in Three Jordanian Populations: Circassians, Chechens and Jordanian-Arabs. | 2 |
| 34740282 | 2022 | Role of cytochrome P450 2C8 genetic polymorphism and epoxygenase uncoupling in periodontal remodelling affecting orthodontic treatment. | 1 |
| 35134542 | 2022 | CYP2C8, CYP2C9, and CYP2C19 Characterization Using Next-Generation Sequencing and Haplotype Analysis: A GeT-RM Collaborative Project. | 18 |
| 35780191 | 2022 | The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals. | 4 |
| 36246885 | 2022 | The impact of genetic variants in the CYP2C8 gene on bladder cancer susceptibility. | 1 |
| 36286958 | 2022 | [Evaluation of the association of polymorphisms of the CYP2C8 gene with the efficacy and safety of ketorolac in patients with postoperative pain syndrome]. | 0 |
Citation
Dessen P
CYP2C8 (cytochrome P450 family 2 subfamily C member 8)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/40244/cyp2c8
