CYP2C8 (cytochrome P450 family 2 subfamily C member 8)

2003-06-01 Affiliation

Identity

HGNC

CYP2C8

LOCATION

10q23.33

LOCUSID

1558

ALIAS

CPC8,CYP2C8DM,CYPIIC8,MP-12/MP-20

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1558
MIM: 601129
HGNC: 2622
Ensembl: ENSG00000138115

Variants:

dbSNP: 1558
ClinVar: 1558
TCGA: ENSG00000138115
COSMIC: CYP2C8

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000138115	ENST00000371270	P10632
ENSG00000138115	ENST00000490994	E9PLI9
ENSG00000138115	ENST00000525991	E9PIW6
ENSG00000138115	ENST00000527420	G3V188
ENSG00000138115	ENST00000535898	P10632
ENSG00000138115	ENST00000539050	B7Z1F5
ENSG00000138115	ENST00000623108	B7Z1F5
ENSG00000138115	ENST00000628935	A0A0D9SG51

Expression (GTEx)

100

200

300

400

500

600

700

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Arachidonic acid metabolism	KEGG	ko00590
Linoleic acid metabolism	KEGG	ko00591
Retinol metabolism	KEGG	ko00830
Drug metabolism - cytochrome P450	KEGG	ko00982
Arachidonic acid metabolism	KEGG	hsa00590
Linoleic acid metabolism	KEGG	hsa00591
Retinol metabolism	KEGG	hsa00830
Drug metabolism - cytochrome P450	KEGG	hsa00982
Metabolic pathways	KEGG	hsa01100
Serotonergic synapse	KEGG	hsa04726
Chemical carcinogenesis	KEGG	hsa05204
Chemical carcinogenesis	KEGG	ko05204
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Arachidonic acid metabolism	REACTOME	R-HSA-2142753
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	REACTOME	R-HSA-2142816
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	REACTOME	R-HSA-2142670
Biological oxidations	REACTOME	R-HSA-211859
Phase 1 - Functionalization of compounds	REACTOME	R-HSA-211945
Cytochrome P450 - arranged by substrate type	REACTOME	R-HSA-211897
Xenobiotics	REACTOME	R-HSA-211981
CYP2E1 reactions	REACTOME	R-HSA-211999

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA10235	zoledronate	Chemical	ClinicalAnnotation	associated		PD	18594024
PA128406954	Weight gain	Disease	VariantAnnotation	ambiguous		PD	27271184
PA128406956	fluorouracil	Chemical	ClinicalAnnotation	associated		PD
PA133950441	hmg coa reductase inhibitors	Chemical	Pathway	associated
PA164712563	Bisphosphonates	Chemical	ClinicalAnnotation, VariantAnnotation, VipGene	ambiguous		PD	21396799, 18594024
PA164712580	Calcineurin inhibitors	Chemical	VariantAnnotation	associated		PD	23426640
PA164746311	everolimus	Chemical	VariantAnnotation	not associated		PD	23797529
PA164748728	mycophenolic acid	Chemical	Pathway, VipGene	associated			22572835, 24220207
PA164925725	Toxic liver disease	Disease	VariantAnnotation	ambiguous		PD	17241877, 25504632
PA165291492	pazopanib	Chemical	VariantAnnotation	associated		PD	25504632
PA165817016	Kidney Transplantation	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	18769365, 23426640, 24681964, 28316087
PA165958682	CYP2C8*1B	Haplotype	VipGene	associated			17923851, 12429347
PA165958683	CYP2C8*1C	Haplotype	VipGene	associated			12429347
PA165958684	CYP2C8*2	Haplotype	VipGene	associated			17361129, 20459297, 23536207, 11668219
PA165958685	CYP2C8*3	Haplotype	VipGene	associated			11767116, 12429347, 12435384, 12530467, 12756196, 15655291, 15900280, 16164496, 17361129, 17923851, 19614891, 20421446, 20459297, 20665013, 23536207, 11668219
PA165958686	CYP2C8*4	Haplotype	VipGene	associated			17923851, 18574320, 20459297, 20848147, 23536207, 12429347
PA166114458	heart transplantation	Disease	VariantAnnotation	not associated		PD	23797529
PA166122590	simeprevir	Chemical	LabelAnnotation	associated
PA166131631	glomerular filtration rate	Disease	VariantAnnotation	associated			28316087
PA166153431	flibanserin	Chemical	LabelAnnotation	associated
PA166153961	rs1058930	Variant	VipGene	associated			17923851, 18574320, 20459297, 20848147, 23536207, 12429347
PA166154085	rs7909236	Variant	VipGene	associated			17923851, 12429347
PA166154110	rs10509681	Variant	VipGene	associated			11767116, 12429347, 12435384, 12530467, 12756196, 15655291, 15900280, 16164496, 17361129, 17923851, 19614891, 20421446, 20459297, 20665013, 23536207, 11668219
PA166154140	rs11572080	Variant	VipGene	associated			11767116, 12429347, 12435384, 12530467, 12756196, 15655291, 15900280, 16164496, 17361129, 17923851, 19614891, 20421446, 20459297, 20665013, 23536207, 11668219
PA166154141	rs11572103	Variant	VipGene	associated			17361129, 20459297, 23536207, 11668219
PA166154160	rs17110453	Variant	VipGene	associated			12429347
PA166163418	rucaparib	Chemical	LabelAnnotation	associated
PA166163692	diclofenac acyl glucuronide	Chemical	VariantAnnotation	associated	PK		29203276
PA378	NR1I2	Gene	Pathway	associated			21151855
PA443450	Asthma	Disease	ClinicalAnnotation	associated	PK		28940478
PA443560	Breast Neoplasms	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	24599932, 25495407, 30520341
PA443622	Carcinoma, Non-Small-Cell Lung	Disease	ClinicalAnnotation	associated		PD	31616045
PA443886	Diabetes Mellitus	Disease	VariantAnnotation	ambiguous		PD	27271184
PA443937	Drug Toxicity	Disease	ClinicalAnnotation	associated		PD	20212519
PA444682	Kidney Diseases	Disease	VariantAnnotation	ambiguous		PD
PA444985	Multiple Myeloma	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous		PD	18594024
PA445113	Neutropenia	Disease	ClinicalAnnotation	associated		PD
PA445187	Osteonecrosis	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous		PD	18594024
PA445204	Ovarian Neoplasms	Disease	VariantAnnotation	ambiguous	PK	PD	20368717, 21327421
PA445301	Peripheral Nervous System Diseases	Disease	VariantAnnotation	ambiguous		PD	24599932, 26115084
PA445846	Thrombocytopenia	Disease	ClinicalAnnotation	associated		PD	31616045
PA446975	Neurotoxicity Syndromes	Disease	ClinicalAnnotation	associated		PD	20212519
PA447247	liver transplantation	Disease	VariantAnnotation	ambiguous		PD
PA448404	amodiaquine	Chemical	ClinicalAnnotation, Pathway, VariantAnnotation, VipGene	associated	PK	PD	21998472, 23204183, 17361129, 18855526
PA448500	atorvastatin	Chemical	Pathway	associated
PA448785	carbamazepine	Chemical	Pathway	associated			21738081
PA448803	carboplatin	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous		PD	21327421, 31616045
PA448871	celecoxib	Chemical	VariantAnnotation	not associated	PK		23996211
PA448897	cerivastatin	Chemical	VariantAnnotation, VipGene	associated	PK		15365880, 11844864
PA449053	clopidogrel	Chemical	Literature, MultilinkAnnotation	associated			24971633
PA449165	cyclophosphamide	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous		PD	24599932
PA449167	cyclosporine	Chemical	VariantAnnotation	ambiguous		PD	23426640
PA449293	diclofenac	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	17241877, 18548238, 29203276
PA449412	doxorubicin	Chemical	VariantAnnotation	not associated		PD
PA449476	epirubicin	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous		PD	24599932
PA449688	fluvastatin	Chemical	Pathway	associated
PA449748	gemcitabine	Chemical	ClinicalAnnotation	associated		PD	31616045
PA449957	ibuprofen	Chemical	ClinicalAnnotation, Pathway, VariantAnnotation, VipGene	associated	PK	PD	18216720, 18694831, 19480553, 15289789, 18694831, 19480553, 25502615, 26122864, 30562214
PA450272	lovastatin	Chemical	Pathway	associated
PA450546	montelukast	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PK		28940478
PA450566	mycophenolate mofetil	Chemical	ClinicalAnnotation	associated		PD	24681964
PA450761	paclitaxel	Chemical	ClinicalAnnotation, Pathway, VariantAnnotation, VipGene	ambiguous	PK	PD	17224914, 17925548, 19143748, 20212519, 20368717, 22527201, 23215890, 11668219, 11767116, 12429347, 16299241, 18574320, 20212519, 20368717, 21151855, 21327421, 24599932, 25495407, 25504632, 26115084, 30520341
PA450767	pamidronate	Chemical	ClinicalAnnotation	associated		PD	18594024
PA450970	pioglitazone	Chemical	ClinicalAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	17913194, 23370354, 17178266, 22625877, 23712614, 27271184
PA451234	repaglinide	Chemical	ClinicalAnnotation, Pathway, VariantAnnotation, VipGene	associated	PK	PD	15961978, 18388877, 21270106, 14534525, 17923851
PA451283	rosiglitazone	Chemical	ClinicalAnnotation, Pathway, VariantAnnotation, VipGene	associated	PK	PD	23426382, 17178266, 23426382, 27271184
PA451363	simvastatin	Chemical	Pathway, VariantAnnotation	associated		PD	25504632
PA451578	tacrolimus	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	18769365, 23426640, 28316087
PA7000	sorafenib	Chemical	Pathway	associated			28362716

References

Pubmed ID	Year	Title	Citations
19706858	2009	Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.	307
19833260	2009	The SLCO1B1*5 genetic variant is associated with statin-induced side effects.	116
16538176	2006	Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions.	112
17048007	2007	Association of warfarin dose with genes involved in its action and metabolism.	100
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
14676196	2004	Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site.	82
11668219	2001	Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid.	76
16385451	2006	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	69
17975119	2008	Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.	65
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62

Citation

Dessen P

CYP2C8 (cytochrome P450 family 2 subfamily C member 8)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40244/cyp2c8