CYP2J2 (cytochrome P450 family 2 subfamily J member 2)

2007-09-01  

Identity

HGNC
CYP2J2
LOCATION
1p32.1
LOCUSID
1573
ALIAS
CPJ2,CYPIIJ2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1573
MIM: 601258
HGNC: 2634
Ensembl: ENSG00000134716

Variants:

dbSNP: 1573
ClinVar: 1573
TCGA: ENSG00000134716
COSMIC: CYP2J2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134716ENST00000371204P51589
ENSG00000134716ENST00000466095A0A3B3IU95
ENSG00000134716ENST00000468257A0A3B3IT99
ENSG00000134716ENST00000469406A0A3B3ITF2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Arachidonic acid metabolismKEGGko00590
Linoleic acid metabolismKEGGko00591
Arachidonic acid metabolismKEGGhsa00590
Linoleic acid metabolismKEGGhsa00591
Metabolic pathwaysKEGGhsa01100
Serotonergic synapseKEGGhsa04726
Ovarian steroidogenesisKEGGhsa04913
Ovarian steroidogenesisKEGGko04913
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)REACTOMER-HSA-2142670
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897
XenobioticsREACTOMER-HSA-211981
Fatty acidsREACTOMER-HSA-211935

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164746058albendazoleChemicalVipGeneassociated19923256
PA164749056danazolChemicalVipGeneassociated19923256
PA165817016Kidney TransplantationDiseaseClinicalAnnotationassociatedPD28316087
PA166153598rs890293VariantVipGeneassociated15861034, 15864120, 16202848, 17126841, 17327508, 17475630, 18496133, 19851119, 11901223
PA443796Coronary Artery DiseaseDiseaseVipGeneassociated
PA444552HypertensionDiseaseVipGeneassociated15864120
PA445019Myocardial InfarctionDiseaseVipGeneassociated17126841
PA448383amiodaroneChemicalVipGeneassociated19923256
PA448498astemizoleChemicalVipGeneassociated15861034
PA449293diclofenacChemicalVipGeneassociated15861034
PA450386mesoridazineChemicalVipGeneassociated19923256
PA450572nabumetoneChemicalVipGeneassociated19923256
PA451578tacrolimusChemicalClinicalAnnotationassociatedPD28316087
PA451619terfenadineChemicalVipGeneassociated15861034
PA451666thioridazineChemicalVipGeneassociated19923256

References

Pubmed IDYearTitleCitations
365875092023CYP2C8 and CYP2J2 gene variations increase the risk of hypertensive intracerebral hemorrhage.0
365875092023CYP2C8 and CYP2J2 gene variations increase the risk of hypertensive intracerebral hemorrhage.0
362692802022Endothelial CYP2J2 overexpression restores the BRB via METTL3-mediated ANXA1 upregulation.6
362692802022Endothelial CYP2J2 overexpression restores the BRB via METTL3-mediated ANXA1 upregulation.6
342582612021CYP2J2 Is a Diagnostic and Prognostic Biomarker Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma.7
347740512021CYP2J2 and EETs protect against pulmonary arterial hypertension with lung ischemia-reperfusion injury in vivo and in vitro.7
342582612021CYP2J2 Is a Diagnostic and Prognostic Biomarker Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma.7
347740512021CYP2J2 and EETs protect against pulmonary arterial hypertension with lung ischemia-reperfusion injury in vivo and in vitro.7
319025552020Association of CYP2J2 polymorphism with susceptibility to psoriasis in Turkish population: a case-control study.1
322102982020CYP2J2 Modulates Diverse Transcriptional Programs in Adult Human Cardiomyocytes.8
322240172020Influence of the CYP2J2 Gene Polymorphisms on Chronic Obstructive Pulmonary Disease Risk in the Chinese Han Population.1
3331234120206,8-Diprenylorobol Induces Apoptosis in Human Hepatocellular Carcinoma Cells via Activation of FOXO3 and Inhibition of CYP2J2.6
333352332020Molecular determinant of substrate binding and specificity of cytochrome P450 2J2.2
319025552020Association of CYP2J2 polymorphism with susceptibility to psoriasis in Turkish population: a case-control study.1
322102982020CYP2J2 Modulates Diverse Transcriptional Programs in Adult Human Cardiomyocytes.8

Citation

Dessen P

CYP2J2 (cytochrome P450 family 2 subfamily J member 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-09-01

Online version: http://atlasgeneticsoncology.org/gene/49722/cyp2j2