CYP2S1 (cytochrome P450 family 2 subfamily S member 1)

2003-06-01  

Identity

HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
CYPIIS1
FUSION GENES

Other Information

Locus ID:

NCBI: 29785
MIM: 611529
HGNC: 15654
Ensembl: ENSG00000167600

Variants:

dbSNP: 29785
ClinVar: 29785
TCGA: ENSG00000167600
COSMIC: CYP2S1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167600ENST00000310054Q96SQ9
ENSG00000167600ENST00000593545M0R2G8
ENSG00000167600ENST00000593890M0QYI2
ENSG00000167600ENST00000595590M0QY51
ENSG00000167600ENST00000597754M0R152
ENSG00000167600ENST00000600561M0R057

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Retinol metabolismKEGGko00830
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Retinol metabolismKEGGhsa00830
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897
XenobioticsREACTOMER-HSA-211981
CYP2E1 reactionsREACTOMER-HSA-211999
Miscellaneous substratesREACTOMER-HSA-211958

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
172773132007A novel promoter element containing multiple overlapping xenobiotic and hypoxia response elements mediates induction of cytochrome P4502S1 by both dioxin and hypoxia.20
197133582009Functional characterization of human cytochrome P450 2S1 using a synthetic gene-expressed protein in Escherichia coli.19
214302342011Cytochrome P450 2S1 is reduced by NADPH-cytochrome P450 reductase.13
232240812013Cytochrome P4502S1: a novel monocyte/macrophage fatty acid epoxygenase in human atherosclerotic plaques.12
220391722012Characterization of a human keratinocyte HaCaT cell line model to study the regulation of CYP2S1.6
228636832012Cytochrome P450 2S1 depletion enhances cell proliferation and migration in bronchial epithelial cells, in part, through modulation of prostaglandin E(2) synthesis.6
236827352013Reduction of aromatic and heterocyclic aromatic N-hydroxylamines by human cytochrome P450 2S1.6
172806602007Expression of CYP2S1 in human hepatic stellate cells.4
193684912009Characterization and expression of extrahepatic CYP2S1.4
193430462009Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.3

Citation

Dessen P

CYP2S1 (cytochrome P450 family 2 subfamily S member 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40249/cyp2s1