CYP3A43 (cytochrome P450 family 3 subfamily A member 43)

2007-02-01  

Identity

HGNC
LOCATION
7q22.1
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 64816
MIM: 606534
HGNC: 17450
Ensembl: ENSG00000021461

Variants:

dbSNP: 64816
ClinVar: 64816
TCGA: ENSG00000021461
COSMIC: CYP3A43

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000021461ENST00000222382Q9HB55
ENSG00000021461ENST00000312017Q9HB55
ENSG00000021461ENST00000342499F8W6L8
ENSG00000021461ENST00000354829Q9HB55
ENSG00000021461ENST00000415413E9PDL8
ENSG00000021461ENST00000417625Q9HB55
ENSG00000021461ENST00000433277E7EMH4
ENSG00000021461ENST00000434806Q9HB55
ENSG00000021461ENST00000436834E9PG90
ENSG00000021461ENST00000444905C9JA26
ENSG00000021461ENST00000631161Q9HB50

Expression (GTEx)

0
1
2
3
4
5

Pathways

PathwaySourceExternal ID
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897
XenobioticsREACTOMER-HSA-211981
Miscellaneous substratesREACTOMER-HSA-211958

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA165108401Acute coronary syndromeDiseaseClinicalAnnotationassociatedPK25935875
PA165374673ticagrelorChemicalClinicalAnnotationassociatedPK25935875
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPKPD21519338, 24595013
PA450688olanzapineChemicalClinicalAnnotationassociatedPKPD21519338, 24595013

References

Pubmed IDYearTitleCitations
155487192004CYP3A4, CYP3A5, and CYP3A43 genotypes and haplotypes in the etiology and severity of prostate cancer.31
197891902009A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers.23
158946822005CYP3A43 Pro(340)Ala polymorphism and prostate cancer risk in African Americans and Caucasians.12
158946822005CYP3A43 Pro(340)Ala polymorphism and prostate cancer risk in African Americans and Caucasians.12
185669912008Joint effects of inflammation and androgen metabolism on prostate cancer severity.11
251508452015Genetic variation in CYP3A43 is associated with response to antipsychotic medication.9
205297632010Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE.8
210810282010Genetic variations in androgen metabolism genes and associations with prostate cancer in South African men.4
193430462009Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.3
146955442004First report of a genetic polymorphism of the cytochrome P450 3A43 (CYP3A43) gene: identification of a loss-of-function variant.2

Citation

Dessen P

CYP3A43 (cytochrome P450 family 3 subfamily A member 43)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43751/cyp3a43