CYP4F3 (cytochrome P450 family 4 subfamily F member 3)

2009-03-01  

Identity

HGNC
LOCATION
19p13.12
LOCUSID
ALIAS
CPF3,CYP4F,CYPIVF3,LTB4H
FUSION GENES

Other Information

Locus ID:

NCBI: 4051
MIM: 601270
HGNC: 2646
Ensembl: ENSG00000186529

Variants:

dbSNP: 4051
ClinVar: 4051
TCGA: ENSG00000186529
COSMIC: CYP4F3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186529ENST00000221307Q08477
ENSG00000186529ENST00000221307A0A024R7J8
ENSG00000186529ENST00000585846Q08477
ENSG00000186529ENST00000585846A0A024R7I2
ENSG00000186529ENST00000586182Q08477
ENSG00000186529ENST00000586182A0A024R7I2
ENSG00000186529ENST00000587360K7EJZ8
ENSG00000186529ENST00000591058Q08477
ENSG00000186529ENST00000591058A0A024R7I2
ENSG00000186529ENST00000592424V9GYA1

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Arachidonic acid metabolismKEGGko00590
Arachidonic acid metabolismKEGGhsa00590
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of Leukotrienes (LT) and Eoxins (EX)REACTOMER-HSA-2142691
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897
Fatty acidsREACTOMER-HSA-211935
EicosanoidsREACTOMER-HSA-211979
Miscellaneous substratesREACTOMER-HSA-211958

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
244064702014Interactions between the dietary polyunsaturated fatty acid ratio and genetic factors determine susceptibility to pediatric Crohn's disease.26
185777682008Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism.24
180657492008Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11.21
163803832006Cytochrome P-450 4F18 is the leukotriene B4 omega-1/omega-2 hydroxylase in mouse polymorphonuclear leukocytes: identification as the functional orthologue of human polymorphonuclear leukocyte CYP4F3A in the down-regulation of responses to LTB4.19
289918562017Genetic Polymorphisms in Fatty Acid Metabolism Modify the Association Between Dietary n3: n6 Intake and Risk of Ulcerative Colitis: A Prospective Cohort Study.9
185664752008CYP4F3B is induced by PGA1 in human liver cells: a regulation of the 20-HETE synthesis.7
227062302012Human cytochrome P450 4F3: structure, functions, and prospects.7
127094242003Myeloid expression of cytochrome P450 4F3 is determined by a lineage-specific alternative promoter.4
179801682007Expression and physiological function of CYP4F subfamily in human eosinophils.3

Citation

Dessen P

CYP4F3 (cytochrome P450 family 4 subfamily F member 3)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50797/cyp4f3