CYRIB (CYFIP related Rac1 interactor B)

2019-04-01  

Identity

HGNC
CYRIB
LOCATION
8q24.21
LOCUSID
51571
ALIAS
BM-009,CYRI,CYRI-B,FAM49B,L1

Other Information

Locus ID:

NCBI: 51571
MIM: 617978
HGNC: 25216
Ensembl: ENSG00000153310

Variants:

dbSNP: 51571
ClinVar: 51571
TCGA: ENSG00000153310
COSMIC: CYRIB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153310ENST00000401979Q9NUQ9
ENSG00000153310ENST00000401979A0A024R9G4
ENSG00000153310ENST00000517654Q9NUQ9
ENSG00000153310ENST00000517654A0A024R9G4
ENSG00000153310ENST00000517672E5RK61
ENSG00000153310ENST00000518167E5RFS4
ENSG00000153310ENST00000518283E5RIR8
ENSG00000153310ENST00000519020E5RHU5
ENSG00000153310ENST00000519070E5RH75
ENSG00000153310ENST00000519110Q9NUQ9
ENSG00000153310ENST00000519110A0A024R9G4
ENSG00000153310ENST00000519142E5RI16
ENSG00000153310ENST00000519540Q9NUQ9
ENSG00000153310ENST00000519540A0A024R9G4
ENSG00000153310ENST00000519824Q9NUQ9
ENSG00000153310ENST00000519824A0A024R9G4
ENSG00000153310ENST00000520204E5RJL8
ENSG00000153310ENST00000520254E5RGI7
ENSG00000153310ENST00000522250Q9NUQ9
ENSG00000153310ENST00000522361E5RK81
ENSG00000153310ENST00000522746Q9NUQ9
ENSG00000153310ENST00000522746A0A024R9G4
ENSG00000153310ENST00000522941Q9NUQ9
ENSG00000153310ENST00000523509Q9NUQ9
ENSG00000153310ENST00000523509A0A024R9G4
ENSG00000153310ENST00000523993E5RJE1
ENSG00000153310ENST00000615041A0A087X178
ENSG00000153310ENST00000639004A0A1W2PRQ0

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

References

Pubmed IDYearTitleCitations
215555182011The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.60
252840532015Urine, peritoneal fluid and omental fat proteomes of reproductive age women: Endometriosis-related changes and associations with endocrine disrupting chemicals.8
290591642018FAM49B, a novel regulator of mitochondrial function and integrity that suppresses tumor metastasis.7
296321892018Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation.6
312855852019CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection.3

Citation

Dessen P

CYRIB (CYFIP related Rac1 interactor B)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57975/cyrib