Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CYTH1 (cytohesin 1)

Identity

Alias_namesPSCD1
pleckstrin homology, Sec7 and coiled-coil domains 1
Alias_symbol (synonym)B2-1
D17S811E
cytohesin-1
Other aliasCYTOHESIN-1
SEC7
HGNC (Hugo) CYTH1
LocusID (NCBI) 9267
Atlas_Id 43432
Location 17q25.3  [Link to chromosome band 17q25]
Location_base_pair Starts at 78674048 and ends at 78782273 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BCAS3 (17q23.2) / CYTH1 (17q25.3)CDC42EP5 (19q13.42) / CYTH1 (17q25.3)CYTH1 (17q25.3) / CYTH1 (17q25.3)
CYTH1 (17q25.3) / EIF3H (8q23.3)CYTH1 (17q25.3) / KSR1 (17q11.1)CYTH1 (17q25.3) / MRC2 (17q23.2)
CYTH1 (17q25.3) / PRPSAP1 (17q25.1)CYTH1 (17q25.3) / RASA3 (13q34)CYTH1 (17q25.3) / SYT1 (12q21.2)
CYTH1 (17q25.3) / TERF2 (16q22.1)CYTH1 (17q25.3) / USP36 (17q25.3)CYTH1 (17q25.3) / ZC3H7A (16p13.13)
EXOC7 (17q25.1) / CYTH1 (17q25.3)LGALS3BP (17q25.3) / CYTH1 (17q25.3)MLLT10 (10p12.31) / CYTH1 (17q25.3)
SNPH (20p13) / CYTH1 (17q25.3)USP36 (17q25.3) / CYTH1 (17q25.3)BCAS3 17q23.2 / CYTH1 17q25.3
CDC42EP5 19q13.42 / CYTH1 17q25.3CYTH1 17q25.3 / KSR1 17q11.1CYTH1 17q25.3 / MRC2 17q23.2
CYTH1 17q25.3 / USP36 17q25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 8 ]
  t(8;17)(q24;q25) CYTH1/EIF3H
t(17;17)(q11;q25) CYTH1/KSR1
t(17;17)(q23;q25) BCAS3/CYTH1
t(17;17)(q23;q25) CYTH1/MRC2
CYTH1/PRPSAP1 (17q25)
CYTH1/USP36 (17q25)
EXOC7/CYTH1 (17q25)
t(17;19)(q25;q13) CDC42EP5/CYTH1

External links

Nomenclature
HGNC (Hugo)CYTH1   9501
Cards
Entrez_Gene (NCBI)CYTH1  9267  cytohesin 1
AliasesB2-1; CYTOHESIN-1; D17S811E; PSCD1; 
SEC7
GeneCards (Weizmann)CYTH1
Ensembl hg19 (Hinxton)ENSG00000108669 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108669 [Gene_View]  ENSG00000108669 [Sequence]  chr17:78674048-78782273 [Contig_View]  CYTH1 [Vega]
ICGC DataPortalENSG00000108669
TCGA cBioPortalCYTH1
AceView (NCBI)CYTH1
Genatlas (Paris)CYTH1
WikiGenes9267
SOURCE (Princeton)CYTH1
Genetics Home Reference (NIH)CYTH1
Genomic and cartography
GoldenPath hg38 (UCSC)CYTH1  -     chr17:78674048-78782273 -  17q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CYTH1  -     17q25.3   [Description]    (hg19-Feb_2009)
GoldenPathCYTH1 - 17q25.3 [CytoView hg19]  CYTH1 - 17q25.3 [CytoView hg38]
Genome Data Viewer NCBICYTH1 [Mapview hg19]  
OMIM182115   
Gene and transcription
Genbank (Entrez)AA030002 AF054997 AK091369 AK123894 AK293894
RefSeq transcript (Entrez)NM_001292018 NM_001292019 NM_001365037 NM_001365038 NM_001365039 NM_001365040 NM_001365041 NM_004762 NM_017456
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CYTH1
Alternative Splicing GalleryENSG00000108669
Gene ExpressionCYTH1 [ NCBI-GEO ]   CYTH1 [ EBI - ARRAY_EXPRESS ]   CYTH1 [ SEEK ]   CYTH1 [ MEM ]
Gene Expression Viewer (FireBrowse)CYTH1 [ Firebrowse - Broad ]
GenevisibleExpression of CYTH1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9267
GTEX Portal (Tissue expression)CYTH1
Human Protein AtlasENSG00000108669-CYTH1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15438   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15438  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15438
Splice isoforms : SwissVarQ15438
PhosPhoSitePlusQ15438
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)    SEC7 (PS50190)   
Domains : Interpro (EBI)PH-like_dom_sf    PH_domain    Sec7_C_sf    Sec7_dom    Sec7_dom_sf   
Domain families : Pfam (Sanger)PH (PF00169)    Sec7 (PF01369)   
Domain families : Pfam (NCBI)pfam00169    pfam01369   
Domain families : Smart (EMBL)PH (SM00233)  Sec7 (SM00222)  
Conserved Domain (NCBI)CYTH1
DMDM Disease mutations9267
PDB (RSDB)1BC9    4A4P   
PDB Europe1BC9    4A4P   
PDB (PDBSum)1BC9    4A4P   
PDB (IMB)1BC9    4A4P   
Structural Biology KnowledgeBase1BC9    4A4P   
SCOP (Structural Classification of Proteins)1BC9    4A4P   
CATH (Classification of proteins structures)1BC9    4A4P   
SuperfamilyQ15438
Human Protein Atlas [tissue]ENSG00000108669-CYTH1 [tissue]
Peptide AtlasQ15438
HPRD01630
IPIIPI00478608   IPI00328228   IPI00936565   IPI01015548   IPI00852664   IPI00852732   IPI00853357   
Protein Interaction databases
DIP (DOE-UCLA)Q15438
IntAct (EBI)Q15438
FunCoupENSG00000108669
BioGRIDCYTH1
STRING (EMBL)CYTH1
ZODIACCYTH1
Ontologies - Pathways
QuickGOQ15438
Ontology : AmiGOGolgi membrane  ARF guanyl-nucleotide exchange factor activity  protein binding  cytoplasm  cytosol  cytosol  plasma membrane  adherens junction  bicellular tight junction  lipid binding  vesicle-mediated transport  regulation of cell adhesion  extrinsic component of cytoplasmic side of plasma membrane  regulation of ARF protein signal transduction  establishment of epithelial cell polarity  
Ontology : EGO-EBIGolgi membrane  ARF guanyl-nucleotide exchange factor activity  protein binding  cytoplasm  cytosol  cytosol  plasma membrane  adherens junction  bicellular tight junction  lipid binding  vesicle-mediated transport  regulation of cell adhesion  extrinsic component of cytoplasmic side of plasma membrane  regulation of ARF protein signal transduction  establishment of epithelial cell polarity  
NDEx NetworkCYTH1
Atlas of Cancer Signalling NetworkCYTH1
Wikipedia pathwaysCYTH1
Orthology - Evolution
OrthoDB9267
GeneTree (enSembl)ENSG00000108669
Phylogenetic Trees/Animal Genes : TreeFamCYTH1
HOGENOMQ15438
Homologs : HomoloGeneCYTH1
Homology/Alignments : Family Browser (UCSC)CYTH1
Gene fusions - Rearrangements
Fusion : MitelmanBCAS3/CYTH1 [17q23.2/17q25.3]  
Fusion : MitelmanCDC42EP5/CYTH1 [19q13.42/17q25.3]  
Fusion : MitelmanCYTH1/EIF3H [17q25.3/8q23.3]  
Fusion : MitelmanCYTH1/KSR1 [17q25.3/17q11.1]  
Fusion : MitelmanCYTH1/MRC2 [17q25.3/17q23.2]  
Fusion : MitelmanCYTH1/PRPSAP1 [17q25.3/17q25.1]  
Fusion : MitelmanCYTH1/USP36 [17q25.3/17q25.3]  
Fusion : MitelmanEXOC7/CYTH1 [17q25.1/17q25.3]  
Fusion PortalBCAS3 17q23.2 CYTH1 17q25.3 BRCA
Fusion PortalCDC42EP5 19q13.42 CYTH1 17q25.3 BRCA
Fusion PortalCYTH1 17q25.3 KSR1 17q11.1 LUAD
Fusion PortalCYTH1 17q25.3 MRC2 17q23.2 BRCA
Fusion PortalCYTH1 17q25.3 USP36 17q25.3 LUAD
Fusion : QuiverCYTH1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCYTH1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYTH1
dbVarCYTH1
ClinVarCYTH1
1000_GenomesCYTH1 
Exome Variant ServerCYTH1
GNOMAD BrowserENSG00000108669
Varsome BrowserCYTH1
Genetic variants : HAPMAP9267
Genomic Variants (DGV)CYTH1 [DGVbeta]
DECIPHERCYTH1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCYTH1 
Mutations
ICGC Data PortalCYTH1 
TCGA Data PortalCYTH1 
Broad Tumor PortalCYTH1
OASIS PortalCYTH1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYTH1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCYTH1
Mutations and Diseases : HGMDCYTH1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutaselect CYTH1
DgiDB (Drug Gene Interaction Database)CYTH1
DoCM (Curated mutations)CYTH1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CYTH1 (select a term)
intoGenCYTH1
Cancer3DCYTH1 (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM182115   
Orphanet
DisGeNETCYTH1
MedgenCYTH1
Genetic Testing Registry CYTH1
NextProtQ15438 [Medical]
TSGene9267
GENETestsCYTH1
Open Targets GeneticsENSG00000108669  [validation]
snp3D : Map Gene to Disease9267
BioCentury BCIQCYTH1
ClinGenCYTH1
Clinical trials, drugs, therapy
Protein Interactions : CTD9267
Pharm GKB GenePA164718528
Clinical trialCYTH1
Miscellaneous
canSAR (ICR)CYTH1 (select the gene name)
HarmonizomeCYTH1
DataMed IndexCYTH1
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCYTH1
EVEXCYTH1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jul 11 19:45:35 CEST 2020
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