CYTH1 (cytohesin 1)

2006-10-01  

Identity

HGNC
LOCATION
17q25.3
LOCUSID
ALIAS
B2-1,CYTOHESIN-1,D17S811E,PSCD1,SEC7
FUSION GENES

Other Information

Locus ID:

NCBI: 9267
MIM: 182115
HGNC: 9501
Ensembl: ENSG00000108669

Variants:

dbSNP: 9267
ClinVar: 9267
TCGA: ENSG00000108669
COSMIC: CYTH1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108669ENST00000361101Q15438
ENSG00000108669ENST00000446868Q15438
ENSG00000108669ENST00000585509Q15438
ENSG00000108669ENST00000586043K7ERV8
ENSG00000108669ENST00000587308K7EKA2
ENSG00000108669ENST00000589296K7EJN5
ENSG00000108669ENST00000589297Q15438
ENSG00000108669ENST00000589768K7ENQ8
ENSG00000108669ENST00000590300K7ENH6
ENSG00000108669ENST00000591455Q15438
ENSG00000108669ENST00000591574K7EL72

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Intra-Golgi trafficREACTOMER-HSA-6811438

References

Pubmed IDYearTitleCitations
157783832005Cross-talk between CD14 and complement receptor 3 promotes phagocytosis of mycobacteria: regulation by phosphatidylinositol 3-kinase and cytohesin-1.34
193464992009Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells.22
126065672003Attenuation of cell adhesion in lymphocytes is regulated by CYTIP, a protein which mediates signal complex sequestration.16
114385222001Actin cytoskeletal association of cytohesin-1 is regulated by specific phosphorylation of its carboxyl-terminal polybasic domain.9
215113402011Cytohesin-1 regulates human blood neutrophil adhesion to endothelial cells through β2 integrin activation.9
228159592012Anti-proliferative effect of cytohesin inhibition in gefitinib-resistant lung cancer cells.9
200186262010Cytohesin-1 regulates the Arf6-phospholipase D signaling axis in human neutrophils: impact on superoxide anion production and secretion.7
270447542016FRMD4A-cytohesin signaling modulates the cellular release of tau.6
278993582017Cytohesin 1 regulates homing and engraftment of human hematopoietic stem and progenitor cells.5
304049492019HGF-induced migration depends on the PI(3,4,5)P3-binding microexon-spliced variant of the Arf6 exchange factor cytohesin-1.4

Citation

Dessen P

CYTH1 (cytohesin 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43432/cyth1