DACT1 (dishevelled binding antagonist of beta catenin 1)

2007-02-01  

Identity

HGNC
LOCATION
14q23.1
LOCUSID
ALIAS
DAPPER,DAPPER1,DPR1,FRODO,HDPR1,TBS2,THYEX3
FUSION GENES

Other Information

Locus ID:

NCBI: 51339
MIM: 607861
HGNC: 17748
Ensembl: ENSG00000165617

Variants:

dbSNP: 51339
ClinVar: 51339
TCGA: ENSG00000165617
COSMIC: DACT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165617ENST00000335867Q9NYF0
ENSG00000165617ENST00000395153Q9NYF0
ENSG00000165617ENST00000421793C9JGV7
ENSG00000165617ENST00000541264B7Z673
ENSG00000165617ENST00000556859B7Z673

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Degradation of DVLREACTOMER-HSA-4641258

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
164463662006Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation.61
155802862005HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: involvement of methylation-mediated gene silencing.36
190737712009Dact1, a nutritionally regulated preadipocyte gene, controls adipogenesis by coordinating the Wnt/beta-catenin signaling network.28
189361002008Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus.25
197338382009Case-control study of six genes asymmetrically expressed in the two cerebral hemispheres: association of BAIAP2 with attention-deficit/hyperactivity disorder.20
249809602014Dapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation.20
202323572010Downregulation of HDPR1 is associated with poor prognosis and affects expression levels of p120-catenin and beta-catenin in nonsmall cell lung cancer.18
226107942012Identification of novel rare mutations of DACT1 in human neural tube defects.14
224705072012Oncogenic function of DACT1 in colon cancer through the regulation of β-catenin.13
258254962015The Wnt Signaling Antagonist Dapper1 Accelerates Dishevelled2 Degradation via Promoting Its Ubiquitination and Aggregate-induced Autophagy.12

Citation

Dessen P

DACT1 (dishevelled binding antagonist of beta catenin 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46315/dact1