Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 168002
MIM: 608966
HGNC: 21231
Ensembl: ENSG00000164488
Variants:
dbSNP: 168002
ClinVar: 168002
TCGA: ENSG00000164488
COSMIC: DACT2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000164488 | ENST00000366795 | Q5SW24 |
| ENSG00000164488 | ENST00000366796 | Q5SW24 |
| ENSG00000164488 | ENST00000607983 | Q5SW24 |
| ENSG00000164488 | ENST00000610183 | Q5SW24 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37610179 | 2024 | Different expression of DACT1, DACT2, and CYCLIN D1 genes in human colorectal cancer tissues and its association with clinicopathological characteristics. | 0 |
| 37610179 | 2024 | Different expression of DACT1, DACT2, and CYCLIN D1 genes in human colorectal cancer tissues and its association with clinicopathological characteristics. | 0 |
| 32454406 | 2020 | Comparative exome sequencing reveals novel candidate genes for retinitis pigmentosa. | 8 |
| 32454406 | 2020 | Comparative exome sequencing reveals novel candidate genes for retinitis pigmentosa. | 8 |
| 29199082 | 2018 | DACT2 Epigenetic Stimulator Exerts Dual Efficacy for Colorectal Cancer Prevention and Treatment. | 11 |
| 29745077 | 2018 | Association between promoter hypermethylation of the DACT2 gene and tumor stages in breast cancer. | 4 |
| 30075814 | 2018 | TET1 exerts its anti-tumor functions via demethylating DACT2 and SFRP2 to antagonize Wnt/β-catenin signaling pathway in nasopharyngeal carcinoma cells. | 16 |
| 30359298 | 2018 | The new 6q27 tumor suppressor DACT2, frequently silenced by CpG methylation, sensitizes nasopharyngeal cancer cells to paclitaxel and 5-FU toxicity via β-catenin/Cdc25c signaling and G2/M arrest. | 24 |
| 29199082 | 2018 | DACT2 Epigenetic Stimulator Exerts Dual Efficacy for Colorectal Cancer Prevention and Treatment. | 11 |
| 29745077 | 2018 | Association between promoter hypermethylation of the DACT2 gene and tumor stages in breast cancer. | 4 |
| 30075814 | 2018 | TET1 exerts its anti-tumor functions via demethylating DACT2 and SFRP2 to antagonize Wnt/β-catenin signaling pathway in nasopharyngeal carcinoma cells. | 16 |
| 30359298 | 2018 | The new 6q27 tumor suppressor DACT2, frequently silenced by CpG methylation, sensitizes nasopharyngeal cancer cells to paclitaxel and 5-FU toxicity via β-catenin/Cdc25c signaling and G2/M arrest. | 24 |
| 27553089 | 2017 | Prognostic significance of the methylation of Wnt pathway antagonists-CXXC4, DACT2, and the inhibitors of sonic hedgehog signaling-ZIC1, ZIC4, and HHIP in head and neck squamous cell carcinomas. | 18 |
| 28077137 | 2017 | Aberrant methylation of DACT1 and DACT2 are associated with tumor progression and poor prognosis in esophageal squamous cell carcinoma. | 9 |
| 28607412 | 2017 | Methylation of DACT2 promotes breast cancer development by activating Wnt signaling. | 10 |
Citation
Dessen P
DACT2 (dishevelled binding antagonist of beta catenin 2)
Atlas Genet Cytogenet Oncol Haematol. 2008-05-01
Online version: http://atlasgeneticsoncology.org/gene/50106/dact2
