DAGLA (diacylglycerol lipase alpha)

2016-10-01  

Identity

HGNC
LOCATION
11q12.2
LOCUSID
ALIAS
C11orf11,DAGL(ALPHA),DAGLALPHA,NSDDR
FUSION GENES

Other Information

Locus ID:

NCBI: 747
MIM: 614015
HGNC: 1165
Ensembl: ENSG00000134780

Variants:

dbSNP: 747
ClinVar: 747
TCGA: ENSG00000134780
COSMIC: DAGLA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134780ENST00000257215Q9Y4D2
ENSG00000134780ENST00000257215A0A024R517
ENSG00000134780ENST00000540717F5GY58

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Retrograde endocannabinoid signalingKEGGhsa04723
Retrograde endocannabinoid signalingKEGGko04723
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Effects of PIP2 hydrolysisREACTOMER-HSA-114508
Arachidonate production from DAGREACTOMER-HSA-426048
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Aldosterone synthesis and secretionKEGGhsa04925
Aldosterone synthesis and secretionKEGGko04925

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
146100532003Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain.308
228279152012Developmental trajectory of the endocannabinoid system in human dorsolateral prefrontal cortex.27
246164512014Influence of dietary fat intake on the endocannabinoid system in lean and obese subjects.15
240760152014Nuclear phospholipase C-β1 and diacylglycerol LIPASE-α in brain cortical neurons.8
291454972017Rare genetic variants in the endocannabinoid system genes CNR1 and DAGLA are associated with neurological phenotypes in humans.5
296143122018Diacylglycerol lipase alpha promotes tumorigenesis in oral cancer by cell-cycle progression.3
294770302018Association between alcoholism and the gene encoding the endocannabinoid synthesizing enzyme diacylglycerol lipase alpha in the Japanese population.0

Citation

Dessen P

DAGLA (diacylglycerol lipase alpha)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56014/dagla