DAOA (D-amino acid oxidase activator)

2019-04-01  

Identity

HGNC
LOCATION
13q33.2
LOCUSID
ALIAS
LG72,SG72

Other Information

Locus ID:

NCBI: 267012
MIM: 607408
HGNC: 21191
Ensembl: ENSG00000182346

Variants:

dbSNP: 267012
ClinVar: 267012
TCGA: ENSG00000182346
COSMIC: DAOA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182346ENST00000329625P59103
ENSG00000182346ENST00000375936P59103
ENSG00000182346ENST00000471432M0R2W9
ENSG00000182346ENST00000473269P59103
ENSG00000182346ENST00000473269A0A024RDZ4
ENSG00000182346ENST00000488534Q8IWM3
ENSG00000182346ENST00000489237M0R2M6
ENSG00000182346ENST00000559369P59103
ENSG00000182346ENST00000595812A2T115
ENSG00000182346ENST00000600388P59103
ENSG00000182346ENST00000601240M0R0L0
ENSG00000182346ENST00000618629P59103

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447215Psychotic DisordersDiseaseClinicalAnnotationassociatedPD19482054
PA450403methamphetamineChemicalClinicalAnnotationassociatedPD19482054

References

Pubmed IDYearTitleCitations
185839792008Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.395
123645862002Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia.163
181982662008No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics.111
149664792004Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder.59
178803992007d-Amino acid oxidase and serine racemase in human brain: normal distribution and altered expression in schizophrenia.54
210416082011Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up.48
170066722007Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia.46
170066722007Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia.46
185445342008pLG72 modulates intracellular D-serine levels through its interaction with D-amino acid oxidase: effect on schizophrenia susceptibility.45
173369462007Impact of schizophrenia candidate genes on schizotypy and cognitive endophenotypes at the population level.43

Citation

Dessen P

DAOA (D-amino acid oxidase activator)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57835/daoa