Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DAP (death associated protein)

Identity

Other alias-
HGNC (Hugo) DAP
LocusID (NCBI) 1611
Atlas_Id 40261
Location 5p15.2  [Link to chromosome band 5p15]
Location_base_pair Starts at 10679230 and ends at 10761275 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CAMTA2 (17p13.2) / DAP (5p15.2)DAP (5p15.2) / CTNNAL1 (9q31.3)DAP (5p15.2) / DAP (5p15.2)
DAP (5p15.2) / RGL2 (6p21.32)DAP (5p15.2) / SNX9 (6q25.3)DAP (5p15.2) / WASF1 (6q21)
LPCAT1 (5p15.33) / DAP (5p15.2)MRPS21 (1q21.2) / DAP (5p15.2)PSMC3 (11p11.2) / DAP (5p15.2)
SNX9 (6q25.3) / DAP (5p15.2)DAP 5p15.2 / RGL2 6p21.32DAP 5p15.2 / SNX9 6q25.3
LPCAT1 5p15.33 / DAP 5p15.2SNX9 6q25.3 / DAP 5p15.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  LPCAT1/DAP (5p15)
t(5;6)(p15;p21) DAP/RGL2
t(5;6)(p15;q25) DAP/SNX9
t(5;6)(p15;q25) SNX9/DAP

External links

Nomenclature
HGNC (Hugo)DAP   2672
Cards
Entrez_Gene (NCBI)DAP  1611  death associated protein
Aliases
GeneCards (Weizmann)DAP
Ensembl hg19 (Hinxton)ENSG00000112977 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112977 [Gene_View]  ENSG00000112977 [Sequence]  chr5:10679230-10761275 [Contig_View]  DAP [Vega]
ICGC DataPortalENSG00000112977
TCGA cBioPortalDAP
AceView (NCBI)DAP
Genatlas (Paris)DAP
WikiGenes1611
SOURCE (Princeton)DAP
Genetics Home Reference (NIH)DAP
Genomic and cartography
GoldenPath hg38 (UCSC)DAP  -     chr5:10679230-10761275 -  5p15.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DAP  -     5p15.2   [Description]    (hg19-Feb_2009)
GoldenPathDAP - 5p15.2 [CytoView hg19]  DAP - 5p15.2 [CytoView hg38]
ImmunoBaseENSG00000112977
Mapping of homologs : NCBIDAP [Mapview hg19]  DAP [Mapview hg38]
OMIM600954   
Gene and transcription
Genbank (Entrez)AK298670 AK311783 BC002726 BI823002 BP265421
RefSeq transcript (Entrez)NM_001291963 NM_004394
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DAP
Cluster EST : UnigeneHs.75189 [ NCBI ]
CGAP (NCI)Hs.75189
Alternative Splicing GalleryENSG00000112977
Gene ExpressionDAP [ NCBI-GEO ]   DAP [ EBI - ARRAY_EXPRESS ]   DAP [ SEEK ]   DAP [ MEM ]
Gene Expression Viewer (FireBrowse)DAP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1611
GTEX Portal (Tissue expression)DAP
Human Protein AtlasENSG00000112977-DAP [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51397   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51397  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51397
Splice isoforms : SwissVarP51397
PhosPhoSitePlusP51397
Domains : Interpro (EBI)DAP1/DAPL1   
Domain families : Pfam (Sanger)DAP (PF15228)   
Domain families : Pfam (NCBI)pfam15228   
Conserved Domain (NCBI)DAP
DMDM Disease mutations1611
Blocks (Seattle)DAP
SuperfamilyP51397
Human Protein Atlas [tissue]ENSG00000112977-DAP [tissue]
Peptide AtlasP51397
HPRD02977
IPIIPI00018117   IPI00030844   IPI00911094   
Protein Interaction databases
DIP (DOE-UCLA)P51397
IntAct (EBI)P51397
FunCoupENSG00000112977
BioGRIDDAP
STRING (EMBL)DAP
ZODIACDAP
Ontologies - Pathways
QuickGOP51397
Ontology : AmiGOautophagy  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of autophagy  negative regulation of autophagy  negative regulation of NF-kappaB transcription factor activity  cellular response to amino acid starvation  cellular response to amino acid starvation  negative regulation of transcription, DNA-templated  death domain binding  death domain binding  apoptotic signaling pathway  apoptotic signaling pathway  
Ontology : EGO-EBIautophagy  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of autophagy  negative regulation of autophagy  negative regulation of NF-kappaB transcription factor activity  cellular response to amino acid starvation  cellular response to amino acid starvation  negative regulation of transcription, DNA-templated  death domain binding  death domain binding  apoptotic signaling pathway  apoptotic signaling pathway  
NDEx NetworkDAP
Atlas of Cancer Signalling NetworkDAP
Wikipedia pathwaysDAP
Orthology - Evolution
OrthoDB1611
GeneTree (enSembl)ENSG00000112977
Phylogenetic Trees/Animal Genes : TreeFamDAP
HOGENOMP51397
Homologs : HomoloGeneDAP
Homology/Alignments : Family Browser (UCSC)DAP
Gene fusions - Rearrangements
Fusion : MitelmanDAP/RGL2 [5p15.2/6p21.32]  
Fusion : MitelmanDAP/SNX9 [5p15.2/6q25.3]  [t(5;6)(p15;q25)]  
Fusion : MitelmanLPCAT1/DAP [5p15.33/5p15.2]  [t(5;5)(p15;p15)]  
Fusion : MitelmanSNX9/DAP [6q25.3/5p15.2]  [t(5;6)(p15;q25)]  
Fusion PortalDAP 5p15.2 RGL2 6p21.32 PRAD
Fusion PortalDAP 5p15.2 SNX9 6q25.3 BRCA
Fusion PortalLPCAT1 5p15.33 DAP 5p15.2 KIRC
Fusion PortalSNX9 6q25.3 DAP 5p15.2 BRCA
Fusion : QuiverDAP
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDAP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DAP
dbVarDAP
ClinVarDAP
1000_GenomesDAP 
Exome Variant ServerDAP
ExAC (Exome Aggregation Consortium)ENSG00000112977
GNOMAD BrowserENSG00000112977
Varsome BrowserDAP
Genetic variants : HAPMAP1611
Genomic Variants (DGV)DAP [DGVbeta]
DECIPHERDAP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDAP 
Mutations
ICGC Data PortalDAP 
TCGA Data PortalDAP 
Broad Tumor PortalDAP
OASIS PortalDAP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDAP  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDAP
Mutations and Diseases : HGMDDAP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DAP
DgiDB (Drug Gene Interaction Database)DAP
DoCM (Curated mutations)DAP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DAP (select a term)
intoGenDAP
Cancer3DDAP(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600954   
Orphanet
DisGeNETDAP
MedgenDAP
Genetic Testing Registry DAP
NextProtP51397 [Medical]
TSGene1611
GENETestsDAP
Target ValidationDAP
Huge Navigator DAP [HugePedia]
snp3D : Map Gene to Disease1611
BioCentury BCIQDAP
ClinGenDAP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1611
Chemical/Pharm GKB GenePA27140
Clinical trialDAP
Miscellaneous
canSAR (ICR)DAP (select the gene name)
DataMed IndexDAP
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDAP
EVEXDAP
GoPubMedDAP
iHOPDAP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:39:44 CET 2019
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