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DARS1 (aspartyl-tRNA synthetase 1)

Identity

Alias (NCBI)DARS
HBSL
aspRS
HGNC (Hugo) DARS1
HGNC Alias nameaspartate tRNA ligase 1, cytoplasmic
LocusID (NCBI) 1615
Atlas_Id 62291
Location 2q21.3  [Link to chromosome band 2q21]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MCM6 DARSTHSD7B DARS
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  MCM6/DARS (2q21)
t(2;2)(q21;q22) DARS/THSD7B
t(2;2)(q21;q22) THSD7B/DARS


External links

Nomenclature
HGNC (Hugo)DARS1   2678
Cards
Entrez_Gene (NCBI)DARS1  1615  aspartyl-tRNA synthetase 1
AliasesDARS; HBSL; aspRS
GeneCards (Weizmann)DARS1
Ensembl hg19 (Hinxton)ENSG00000115866 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115866 [Gene_View]  ENSG00000115866 [Sequence]  - [Contig_View]  DARS1 [Vega]
ICGC DataPortalENSG00000115866
TCGA cBioPortalDARS1
AceView (NCBI)DARS1
Genatlas (Paris)DARS1
WikiGenes1615
SOURCE (Princeton)DARS1
Genetics Home Reference (NIH)DARS1
Genomic and cartography
GoldenPath hg38 (UCSC)DARS1  -  
GoldenPath hg19 (UCSC)DARS1  -  
GoldenPathDARS1 - [CytoView hg19]  DARS1 - [CytoView hg38]
ImmunoBaseENSG00000115866
genome Data Viewer NCBIDARS1 [Mapview hg19]  
OMIM603084   615281   
Gene and transcription
Genbank (Entrez)AK129521 AK222476 AK290607 AY762100 BC000629
RefSeq transcript (Entrez)NM_001293312 NM_001349
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DARS1
Alternative Splicing GalleryENSG00000115866
Gene ExpressionDARS1 [ NCBI-GEO ]   DARS1 [ EBI - ARRAY_EXPRESS ]   DARS1 [ SEEK ]   DARS1 [ MEM ]
Gene Expression Viewer (FireBrowse)DARS1 [ Firebrowse - Broad ]
GenevisibleExpression of DARS1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1615
GTEX Portal (Tissue expression)DARS1
Human Protein AtlasENSG00000115866-DARS1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP14868   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP14868  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP14868
Splice isoforms : SwissVarP14868
PhosPhoSitePlusP14868
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_II (PS50862)   
Domains : Interpro (EBI)Aa-tRNA-synt_II    aa-tRNA-synth_II    Asp-tRNA_synthase_2    Asp/Asn-tRNA-synth_IIb    NA-bd_OB-fold    NA-bd_OB_tRNA   
Domain families : Pfam (Sanger)tRNA-synt_2 (PF00152)    tRNA_anti-codon (PF01336)   
Domain families : Pfam (NCBI)pfam00152    pfam01336   
Conserved Domain (NCBI)DARS1
DMDM Disease mutations1615
Blocks (Seattle)DARS1
PDB (RSDB)4J15    5Y6L    6IY6   
PDB Europe4J15    5Y6L    6IY6   
PDB (PDBSum)4J15    5Y6L    6IY6   
PDB (IMB)4J15    5Y6L    6IY6   
Structural Biology KnowledgeBase4J15    5Y6L    6IY6   
SCOP (Structural Classification of Proteins)4J15    5Y6L    6IY6   
CATH (Classification of proteins structures)4J15    5Y6L    6IY6   
SuperfamilyP14868
Human Protein Atlas [tissue]ENSG00000115866-DARS1 [tissue]
Peptide AtlasP14868
HPRD04361
IPIIPI00216951   IPI01009538   IPI00917399   IPI00917615   IPI00917492   IPI00917920   IPI00917783   
Protein Interaction databases
DIP (DOE-UCLA)P14868
IntAct (EBI)P14868
FunCoupENSG00000115866
BioGRIDDARS1
STRING (EMBL)DARS1
ZODIACDARS1
Ontologies - Pathways
QuickGOP14868
Ontology : AmiGORNA binding  RNA binding  aminoacylase activity  aspartate-tRNA ligase activity  protein binding  ATP binding  cytoplasm  cytosol  cytosol  cytosol  translation  tRNA aminoacylation for protein translation  aspartyl-tRNA aminoacylation  membrane  aminoacyl-tRNA synthetase multienzyme complex  aminoacyl-tRNA synthetase multienzyme complex  synapse  protein-containing complex assembly  extracellular exosome  
Ontology : EGO-EBIRNA binding  RNA binding  aminoacylase activity  aspartate-tRNA ligase activity  protein binding  ATP binding  cytoplasm  cytosol  cytosol  cytosol  translation  tRNA aminoacylation for protein translation  aspartyl-tRNA aminoacylation  membrane  aminoacyl-tRNA synthetase multienzyme complex  aminoacyl-tRNA synthetase multienzyme complex  synapse  protein-containing complex assembly  extracellular exosome  
Pathways : KEGGAminoacyl-tRNA biosynthesis    Alanine and aspartate metabolism   
NDEx NetworkDARS1
Atlas of Cancer Signalling NetworkDARS1
Wikipedia pathwaysDARS1
Orthology - Evolution
OrthoDB1615
GeneTree (enSembl)ENSG00000115866
Phylogenetic Trees/Animal Genes : TreeFamDARS1
HOGENOMP14868
Homologs : HomoloGeneDARS1
Homology/Alignments : Family Browser (UCSC)DARS1
Gene fusions - Rearrangements
Fusion PortalMCM6 DARS
Fusion PortalTHSD7B DARS
Fusion : QuiverDARS1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDARS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DARS1
dbVarDARS1
ClinVarDARS1
1000_GenomesDARS1 
Exome Variant ServerDARS1
GNOMAD BrowserENSG00000115866
Varsome BrowserDARS1
Genetic variants : HAPMAP1615
Genomic Variants (DGV)DARS1 [DGVbeta]
DECIPHERDARS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDARS1 
Mutations
ICGC Data PortalDARS1 
TCGA Data PortalDARS1 
Broad Tumor PortalDARS1
OASIS PortalDARS1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDDARS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch DARS1
DgiDB (Drug Gene Interaction Database)DARS1
DoCM (Curated mutations)DARS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DARS1 (select a term)
intoGenDARS1
Cancer3DDARS1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603084    615281   
Orphanet22297   
DisGeNETDARS1
MedgenDARS1
Genetic Testing Registry DARS1
NextProtP14868 [Medical]
TSGene1615
GENETestsDARS1
Target ValidationDARS1
Huge Navigator DARS1 [HugePedia]
snp3D : Map Gene to Disease1615
BioCentury BCIQDARS1
ClinGenDARS1
Clinical trials, drugs, therapy
Protein Interactions : CTD1615
Pharm GKB GenePA27146
Clinical trialDARS1
Miscellaneous
canSAR (ICR)DARS1 (select the gene name)
HarmonizomeDARS1
DataMed IndexDARS1
Probes
Litterature
PubMed92 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDARS1
EVEXDARS1
GoPubMedDARS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sat Aug 22 19:03:16 CEST 2020

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