DBF4 (DBF4 zinc finger)

2008-03-01  

Identity

HGNC
DBF4
LOCATION
7q21.12
LOCUSID
10926
ALIAS
ASK,CHIF,DBF4A,ZDBF1

Other Information

Locus ID:

NCBI: 10926
MIM: 604281
HGNC: 17364
Ensembl: ENSG00000006634

Variants:

dbSNP: 10926
ClinVar: 10926
TCGA: ENSG00000006634
COSMIC: DBF4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000006634ENST00000265728Q9UBU7
ENSG00000006634ENST00000413643Q9UBU7
ENSG00000006634ENST00000430279B4DXK0
ENSG00000006634ENST00000431138F8WF77

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Cell cycleKEGGhsa04110
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
Activation of ATR in response to replication stressREACTOMER-HSA-176187
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1/S TransitionREACTOMER-HSA-69206
Activation of the pre-replicative complexREACTOMER-HSA-68962
M/G1 TransitionREACTOMER-HSA-68874
DNA Replication Pre-InitiationREACTOMER-HSA-69002
DNA ReplicationREACTOMER-HSA-69306

References

Pubmed IDYearTitleCitations
125355332003An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication.134
187143922008Cdc7-Dbf4 kinase overexpression in multiple cancers and tumor cell lines is correlated with p53 inactivation.43
168995102006Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells.42
172769902007Cdc7-Dbf4 and the human S checkpoint response to UVC.39
198644172010Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activity.31
191116652008The role of Dbf4/Drf1-dependent kinase Cdc7 in DNA-damage checkpoint control.29
168262392006The replication kinase Cdc7-Dbf4 promotes the interaction of the p150 subunit of chromatin assembly factor 1 with proliferating cell nuclear antigen.28
221238272012Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint.24
210369052010Dbf4 regulates the Cdc5 Polo-like kinase through a distinct non-canonical binding interaction.16
185367242008Asymmetric bidirectional replication at the human DBF4 origin.13

Citation

Dessen P

DBF4 (DBF4 zinc finger)

Atlas Genet Cytogenet Oncol Haematol. 2008-03-01

Online version: http://atlasgeneticsoncology.org/gene/50062/dbf4