Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DBF4B (DBF4 zinc finger B)

Identity

Alias (NCBI)ASKL1
CHIFB
DRF1
ZDBF1B
HGNC (Hugo) DBF4B
HGNC Alias symbFLJ13087
DRF1
ASKL1
chifb
ZDBF1B
HGNC Alias namechiffon homolog B (Drosophila)
 zinc finger, DBF-type containing 1B
HGNC Previous nameDBF4 homolog B (S. cerevisiae)
LocusID (NCBI) 80174
Atlas_Id 56410
Location 17q21.31  [Link to chromosome band 17q21]
Location_base_pair Starts at 44708665 and ends at 44752264 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DBF4B (17q21.31) / DYNC2H1 (11q22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;17)(q22;q21) DBF4B/DYNC2H1

External links

Nomenclature
HGNC (Hugo)DBF4B   17883
Cards
Entrez_Gene (NCBI)DBF4B  80174  DBF4 zinc finger B
AliasesASKL1; CHIFB; DRF1; ZDBF1B
GeneCards (Weizmann)DBF4B
Ensembl hg19 (Hinxton)ENSG00000161692 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000161692 [Gene_View]  ENSG00000161692 [Sequence]  chr17:44708665-44752264 [Contig_View]  DBF4B [Vega]
ICGC DataPortalENSG00000161692
TCGA cBioPortalDBF4B
AceView (NCBI)DBF4B
Genatlas (Paris)DBF4B
WikiGenes80174
SOURCE (Princeton)DBF4B
Genetics Home Reference (NIH)DBF4B
Genomic and cartography
GoldenPath hg38 (UCSC)DBF4B  -     chr17:44708665-44752264 +  17q21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DBF4B  -     17q21.31   [Description]    (hg19-Feb_2009)
GoldenPathDBF4B - 17q21.31 [CytoView hg19]  DBF4B - 17q21.31 [CytoView hg38]
ImmunoBaseENSG00000161692
genome Data Viewer NCBIDBF4B [Mapview hg19]  
OMIM611661   
Gene and transcription
Genbank (Entrez)AF448801 AF465820 AK023149 AK125771 AK295296
RefSeq transcript (Entrez)NM_025104 NM_145663
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DBF4B
Alternative Splicing GalleryENSG00000161692
Gene ExpressionDBF4B [ NCBI-GEO ]   DBF4B [ EBI - ARRAY_EXPRESS ]   DBF4B [ SEEK ]   DBF4B [ MEM ]
Gene Expression Viewer (FireBrowse)DBF4B [ Firebrowse - Broad ]
GenevisibleExpression of DBF4B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80174
GTEX Portal (Tissue expression)DBF4B
Human Protein AtlasENSG00000161692-DBF4B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NFT6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NFT6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NFT6
Splice isoforms : SwissVarQ8NFT6
PhosPhoSitePlusQ8NFT6
Domaine pattern : Prosite (Expaxy)ZF_DBF4 (PS51265)   
Domains : Interpro (EBI)Znf_DBF    Znf_DBF_sf   
Domain families : Pfam (Sanger)zf-DBF (PF07535)   
Domain families : Pfam (NCBI)pfam07535   
Domain families : Smart (EMBL)ZnF_DBF (SM00586)  
Conserved Domain (NCBI)DBF4B
DMDM Disease mutations80174
Blocks (Seattle)DBF4B
SuperfamilyQ8NFT6
Human Protein Atlas [tissue]ENSG00000161692-DBF4B [tissue]
Peptide AtlasQ8NFT6
HPRD16840
IPIIPI00168899   IPI00790777   IPI00152878   IPI00303912   IPI00432712   IPI00797871   IPI00981165   IPI00980676   
Protein Interaction databases
DIP (DOE-UCLA)Q8NFT6
IntAct (EBI)Q8NFT6
FunCoupENSG00000161692
BioGRIDDBF4B
STRING (EMBL)DBF4B
ZODIACDBF4B
Ontologies - Pathways
QuickGOQ8NFT6
Ontology : AmiGOnuclear chromatin  nucleic acid binding  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  cell cycle  zinc ion binding  positive regulation of cell proliferation  positive regulation of nuclear cell cycle DNA replication  positive regulation of nuclear cell cycle DNA replication  positive regulation of G2/M transition of mitotic cell cycle  aggresome  protein kinase binding  protein kinase activator activity  Dbf4-dependent protein kinase complex  activation of protein kinase activity  intracellular membrane-bounded organelle  protein serine/threonine kinase activator activity  positive regulation of protein serine/threonine kinase activity  regulation of cell cycle phase transition  
Ontology : EGO-EBInuclear chromatin  nucleic acid binding  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  cell cycle  zinc ion binding  positive regulation of cell proliferation  positive regulation of nuclear cell cycle DNA replication  positive regulation of nuclear cell cycle DNA replication  positive regulation of G2/M transition of mitotic cell cycle  aggresome  protein kinase binding  protein kinase activator activity  Dbf4-dependent protein kinase complex  activation of protein kinase activity  intracellular membrane-bounded organelle  protein serine/threonine kinase activator activity  positive regulation of protein serine/threonine kinase activity  regulation of cell cycle phase transition  
NDEx NetworkDBF4B
Atlas of Cancer Signalling NetworkDBF4B
Wikipedia pathwaysDBF4B
Orthology - Evolution
OrthoDB80174
GeneTree (enSembl)ENSG00000161692
Phylogenetic Trees/Animal Genes : TreeFamDBF4B
HOGENOMQ8NFT6
Homologs : HomoloGeneDBF4B
Homology/Alignments : Family Browser (UCSC)DBF4B
Gene fusions - Rearrangements
Fusion : QuiverDBF4B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDBF4B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DBF4B
dbVarDBF4B
ClinVarDBF4B
1000_GenomesDBF4B 
Exome Variant ServerDBF4B
GNOMAD BrowserENSG00000161692
Varsome BrowserDBF4B
Genetic variants : HAPMAP80174
Genomic Variants (DGV)DBF4B [DGVbeta]
DECIPHERDBF4B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDBF4B 
Mutations
ICGC Data PortalDBF4B 
TCGA Data PortalDBF4B 
Broad Tumor PortalDBF4B
OASIS PortalDBF4B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDBF4B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDBF4B
Mutations and Diseases : HGMDDBF4B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DBF4B
DgiDB (Drug Gene Interaction Database)DBF4B
DoCM (Curated mutations)DBF4B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DBF4B (select a term)
intoGenDBF4B
Cancer3DDBF4B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611661   
Orphanet
DisGeNETDBF4B
MedgenDBF4B
Genetic Testing Registry DBF4B
NextProtQ8NFT6 [Medical]
TSGene80174
GENETestsDBF4B
Target ValidationDBF4B
Huge Navigator DBF4B [HugePedia]
snp3D : Map Gene to Disease80174
BioCentury BCIQDBF4B
ClinGenDBF4B
Clinical trials, drugs, therapy
Protein Interactions : CTD80174
Pharm GKB GenePA143485447
Clinical trialDBF4B
Miscellaneous
canSAR (ICR)DBF4B (select the gene name)
HarmonizomeDBF4B
DataMed IndexDBF4B
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDBF4B
EVEXDBF4B
GoPubMedDBF4B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jul 16 15:10:03 CEST 2020
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