DBI (diazepam binding inhibitor, acyl-CoA binding protein)

2003-08-01  

Identity

HGNC
DBI
LOCATION
2q14.2
LOCUSID
1622
ALIAS
ACBD1,ACBP,CCK-RP,EP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1622
MIM: 125950
HGNC: 2690
Ensembl: ENSG00000155368

Variants:

dbSNP: 1622
ClinVar: 1622
TCGA: ENSG00000155368
COSMIC: DBI

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000155368ENST00000311521P07108
ENSG00000155368ENST00000311521A0A024RAF2
ENSG00000155368ENST00000355857P07108
ENSG00000155368ENST00000393103P07108
ENSG00000155368ENST00000409094P07108
ENSG00000155368ENST00000409094A0A024RAF2
ENSG00000155368ENST00000535617B8ZWD1
ENSG00000155368ENST00000535757P07108
ENSG00000155368ENST00000535757A0A024RAF2
ENSG00000155368ENST00000542275A0A0A0MTI5
ENSG00000155368ENST00000627093P07108
ENSG00000155368ENST00000627305P07108

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
PPAR signaling pathwayKEGGko03320
PPAR signaling pathwayKEGGhsa03320
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Triglyceride BiosynthesisREACTOMER-HSA-75109
Fatty Acyl-CoA BiosynthesisREACTOMER-HSA-75105

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
120153062002The gene encoding the Acyl-CoA-binding protein is activated by peroxisome proliferator-activated receptor gamma through an intronic response element functionally conserved between humans and rodents.40
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
258989852015Long-chain acyl-CoA esters in metabolism and signaling: Role of acyl-CoA binding proteins.33
160424052005Acyl-coenzyme A binding protein expression alters liver fatty acyl-coenzyme A metabolism.19
123962322002Acyl-CoA binding protein is an essential protein in mammalian cell lines.12
248198762014Acyl-coenzyme A-binding protein regulates Beta-oxidation required for growth and survival of non-small cell lung cancer.12
198157042009Genoproteomic mining of urothelial cancer suggests {gamma}-glutamyl hydrolase and diazepam-binding inhibitor as putative urinary markers of outcome after chemotherapy.11
190884332008Transcriptional regulation of HMG-CoA synthase and HMG-CoA reductase genes by human ACBP.10
283208572017Regulation of very-long acyl chain ceramide synthesis by acyl-CoA-binding protein.10

Citation

Dessen P

DBI (diazepam binding inhibitor, acyl-CoA binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40267/dbi