DCAF15 (DDB1 and CUL4 associated factor 15)

2014-11-01  

Identity

HGNC
DCAF15
LOCATION
19p13.12
LOCUSID
90379
ALIAS
C19orf72

Other Information

Locus ID:

NCBI: 90379
HGNC: 25095
Ensembl: ENSG00000132017

Variants:

dbSNP: 90379
ClinVar: 90379
TCGA: ENSG00000132017
COSMIC: DCAF15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132017ENST00000254337Q66K64
ENSG00000132017ENST00000585468K7ELE9
ENSG00000132017ENST00000587307K7ERN0
ENSG00000132017ENST00000591802K7ENG0

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
283027932017Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.48
318192722020Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.2
316860312020Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15.1

Citation

Dessen P

DCAF15 (DDB1 and CUL4 associated factor 15)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62315/dcaf15