DCK (deoxycytidine kinase)

2003-06-01  

Identity

HGNC
LOCATION
4q13.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 1633
MIM: 125450
HGNC: 2704
Ensembl: ENSG00000156136

Variants:

dbSNP: 1633
ClinVar: 1633
TCGA: ENSG00000156136
COSMIC: DCK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156136ENST00000286648P27707
ENSG00000156136ENST00000286648F5CTF3
ENSG00000156136ENST00000503359D6RG38
ENSG00000156136ENST00000504730D6RCP9
ENSG00000156136ENST00000504952D6RFG8
ENSG00000156136ENST00000509617D6R9C6

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Pyrimidine metabolismKEGGko00240
Purine metabolismKEGGhsa00230
Pyrimidine metabolismKEGGhsa00240
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Purine metabolismREACTOMER-HSA-73847
Purine salvageREACTOMER-HSA-74217
Pyrimidine metabolismREACTOMER-HSA-73848
Pyrimidine salvage reactionsREACTOMER-HSA-73614

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA444760Leukemia, Myeloid, AcuteDiseaseClinicalAnnotationassociatedPKPD15564883
PA445218Pancreatic NeoplasmsDiseaseClinicalAnnotationassociatedPD20665488
PA449177cytarabineChemicalClinicalAnnotationassociatedPKPD15564883
PA449212daunorubicinChemicalMultilinkAnnotationassociated25119182
PA449748gemcitabineChemicalClinicalAnnotation, Literature, MultilinkAnnotation, PathwayassociatedPKPD12477049, 20665488, 22705007, 23230131, 25162786
PA449961idarubicinChemicalClinicalAnnotationassociatedPKPD15564883
PA450163lamivudineChemicalPathwayassociated

References

Pubmed IDYearTitleCitations
227050072012Levels of gemcitabine transport and metabolism proteins predict survival times of patients treated with gemcitabine for pancreatic adenocarcinoma.84
178554782007Pharmacogenetics of deoxycytidine kinase: identification and characterization of novel genetic variants.34
200287592010Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity.34
218580902011Mechanisms of resistance to decitabine in the myelodysplastic syndrome.34
195684092009Gemcitabine-based chemogene therapy for pancreatic cancer using Ad-dCK::UMK GDEPT and TS/RR siRNA strategies.30
206654882010Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer.27
224906632012DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells.23
163616992006Identification of in vivo phosphorylation sites on human deoxycytidine kinase. Role of Ser-74 in the control of enzyme activity.21
176020532007An association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients.15
191592292009Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinase.15

Citation

Dessen P

DCK (deoxycytidine kinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40270/dck