Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DCN (decorin)

Identity

Alias_symbol (synonym)DSPG2
SLRR1B
Other aliasCSCD
PG40
PGII
PGS2
HGNC (Hugo) DCN
LocusID (NCBI) 1634
Atlas_Id 40274
Location 12q21.33  [Link to chromosome band 12q21]
Location_base_pair Starts at 91143277 and ends at 91178646 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CD36 (7q21.11) / DCN (12q21.33)DCN (12q21.33) / CRIPAK (4p16.3)DCN (12q21.33) / DCN (12q21.33)
DCN (12q21.33) / MAGI1 (3p14.1)DCN (12q21.33) / SSR1 (6p24.3)DCN (12q21.33) / ZNF263 (16p13.3)
IGFBP4 (17q21.2) / DCN (12q21.33)NECAB3 (20q11.22) / DCN (12q21.33)VPS35 (16q11.2) / DCN (12q21.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(12;16)(q21;q11) VPS35/DCN

External links

Nomenclature
HGNC (Hugo)DCN   2705
Cards
Entrez_Gene (NCBI)DCN  1634  decorin
AliasesCSCD; DSPG2; PG40; PGII; 
PGS2; SLRR1B
GeneCards (Weizmann)DCN
Ensembl hg19 (Hinxton)ENSG00000011465 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000011465 [Gene_View]  ENSG00000011465 [Sequence]  chr12:91143277-91178646 [Contig_View]  DCN [Vega]
ICGC DataPortalENSG00000011465
TCGA cBioPortalDCN
AceView (NCBI)DCN
Genatlas (Paris)DCN
WikiGenes1634
SOURCE (Princeton)DCN
Genetics Home Reference (NIH)DCN
Genomic and cartography
GoldenPath hg38 (UCSC)DCN  -     chr12:91143277-91178646 -  12q21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DCN  -     12q21.33   [Description]    (hg19-Feb_2009)
GoldenPathDCN - 12q21.33 [CytoView hg19]  DCN - 12q21.33 [CytoView hg38]
ImmunoBaseENSG00000011465
Mapping of homologs : NCBIDCN [Mapview hg19]  DCN [Mapview hg38]
OMIM125255   610048   
Gene and transcription
Genbank (Entrez)AF138300 AF138301 AF138302 AF138303 AF138304
RefSeq transcript (Entrez)NM_001920 NM_133503 NM_133504 NM_133505 NM_133506 NM_133507
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DCN
Cluster EST : UnigeneHs.530910 [ NCBI ]
CGAP (NCI)Hs.530910
Alternative Splicing GalleryENSG00000011465
Gene ExpressionDCN [ NCBI-GEO ]   DCN [ EBI - ARRAY_EXPRESS ]   DCN [ SEEK ]   DCN [ MEM ]
Gene Expression Viewer (FireBrowse)DCN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1634
GTEX Portal (Tissue expression)DCN
Human Protein AtlasENSG00000011465-DCN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07585   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP07585  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP07585
Splice isoforms : SwissVarP07585
PhosPhoSitePlusP07585
Domaine pattern : Prosite (Expaxy)LRR (PS51450)   
Domains : Interpro (EBI)Decorin    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    LRR_dom_sf    LRRNT    SLRP_I_decor/aspor/byglycan   
Domain families : Pfam (Sanger)LRR_8 (PF13855)    LRRNT (PF01462)   
Domain families : Pfam (NCBI)pfam13855    pfam01462   
Domain families : Smart (EMBL)LRR_TYP (SM00369)  LRRNT (SM00013)  
Conserved Domain (NCBI)DCN
DMDM Disease mutations1634
Blocks (Seattle)DCN
SuperfamilyP07585
Human Protein Atlas [tissue]ENSG00000011465-DCN [tissue]
Peptide AtlasP07585
HPRD00501
IPIIPI00012119   IPI00219400   IPI00219401   IPI00219403   IPI00219404   IPI01022250   IPI01022113   IPI01021688   IPI01021543   IPI01021358   IPI01021491   IPI01021132   IPI01020978   IPI01020786   IPI01021928   
Protein Interaction databases
DIP (DOE-UCLA)P07585
IntAct (EBI)P07585
FunCoupENSG00000011465
BioGRIDDCN
STRING (EMBL)DCN
ZODIACDCN
Ontologies - Pathways
QuickGOP07585
Ontology : AmiGOkidney development  placenta development  RNA binding  protein binding  collagen binding  glycosaminoglycan binding  extracellular region  extracellular region  collagen type VI trimer  extracellular space  Golgi lumen  skeletal muscle tissue development  aging  response to mechanical stimulus  animal organ morphogenesis  positive regulation of autophagy  negative regulation of endothelial cell migration  positive regulation of phosphatidylinositol 3-kinase signaling  positive regulation of macroautophagy  positive regulation of macroautophagy  negative regulation of angiogenesis  peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan  extracellular matrix structural constituent conferring compression resistance  extracellular matrix structural constituent conferring compression resistance  extracellular matrix organization  chondroitin sulfate biosynthetic process  chondroitin sulfate catabolic process  dermatan sulfate biosynthetic process  response to lipopolysaccharide  wound healing  lysosomal lumen  positive regulation of transcription by RNA polymerase II  protein N-terminus binding  extracellular matrix binding  positive regulation of mitochondrial depolarization  collagen-containing extracellular matrix  collagen-containing extracellular matrix  collagen-containing extracellular matrix  positive regulation of mitochondrial fission  negative regulation of vascular endothelial growth factor signaling pathway  
Ontology : EGO-EBIkidney development  placenta development  RNA binding  protein binding  collagen binding  glycosaminoglycan binding  extracellular region  extracellular region  collagen type VI trimer  extracellular space  Golgi lumen  skeletal muscle tissue development  aging  response to mechanical stimulus  animal organ morphogenesis  positive regulation of autophagy  negative regulation of endothelial cell migration  positive regulation of phosphatidylinositol 3-kinase signaling  positive regulation of macroautophagy  positive regulation of macroautophagy  negative regulation of angiogenesis  peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan  extracellular matrix structural constituent conferring compression resistance  extracellular matrix structural constituent conferring compression resistance  extracellular matrix organization  chondroitin sulfate biosynthetic process  chondroitin sulfate catabolic process  dermatan sulfate biosynthetic process  response to lipopolysaccharide  wound healing  lysosomal lumen  positive regulation of transcription by RNA polymerase II  protein N-terminus binding  extracellular matrix binding  positive regulation of mitochondrial depolarization  collagen-containing extracellular matrix  collagen-containing extracellular matrix  collagen-containing extracellular matrix  positive regulation of mitochondrial fission  negative regulation of vascular endothelial growth factor signaling pathway  
Pathways : KEGGTGF-beta signaling pathway    Proteoglycans in cancer   
NDEx NetworkDCN
Atlas of Cancer Signalling NetworkDCN
Wikipedia pathwaysDCN
Orthology - Evolution
OrthoDB1634
GeneTree (enSembl)ENSG00000011465
Phylogenetic Trees/Animal Genes : TreeFamDCN
HOGENOMP07585
Homologs : HomoloGeneDCN
Homology/Alignments : Family Browser (UCSC)DCN
Gene fusions - Rearrangements
Fusion : MitelmanVPS35/DCN [16q11.2/12q21.33]  [t(12;16)(q21;q11)]  
Fusion : QuiverDCN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDCN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DCN
dbVarDCN
ClinVarDCN
1000_GenomesDCN 
Exome Variant ServerDCN
ExAC (Exome Aggregation Consortium)ENSG00000011465
GNOMAD BrowserENSG00000011465
Varsome BrowserDCN
Genetic variants : HAPMAP1634
Genomic Variants (DGV)DCN [DGVbeta]
DECIPHERDCN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDCN 
Mutations
ICGC Data PortalDCN 
TCGA Data PortalDCN 
Broad Tumor PortalDCN
OASIS PortalDCN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDCN  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDCN
Mutations and Diseases : HGMDDCN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DCN
DgiDB (Drug Gene Interaction Database)DCN
DoCM (Curated mutations)DCN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DCN (select a term)
intoGenDCN
Cancer3DDCN(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM125255    610048   
Orphanet14779   
DisGeNETDCN
MedgenDCN
Genetic Testing Registry DCN
NextProtP07585 [Medical]
TSGene1634
GENETestsDCN
Target ValidationDCN
Huge Navigator DCN [HugePedia]
snp3D : Map Gene to Disease1634
BioCentury BCIQDCN
ClinGenDCN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1634
Chemical/Pharm GKB GenePA27177
Clinical trialDCN
Miscellaneous
canSAR (ICR)DCN (select the gene name)
DataMed IndexDCN
Probes
Litterature
PubMed226 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDCN
EVEXDCN
GoPubMedDCN
iHOPDCN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:39:53 CET 2019
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