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DCP1A (decapping mRNA 1A)

Identity

Alias_namesDCP1 decapping enzyme homolog A (S. cerevisiae)
Alias_symbol (synonym)HSA275986
SMIF
SMAD4IP1
Other aliasNbla00360
HGNC (Hugo) DCP1A
LocusID (NCBI) 55802
Atlas_Id 54250
Location 3p21.1  [Link to chromosome band 3p21]
Location_base_pair Starts at 53283425 and ends at 53347627 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DCP1A (3p21.1) / CSH2 (17q23.3)DCP1A (3p21.1) / DCP1A (3p21.1)KMT2A (11q23.3) / DCP1A (3p21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(3;11)(p21;q23) KMT2A/DCP1A

External links

Nomenclature
HGNC (Hugo)DCP1A   18714
Cards
Entrez_Gene (NCBI)DCP1A  55802  decapping mRNA 1A
AliasesHSA275986; Nbla00360; SMAD4IP1; SMIF
GeneCards (Weizmann)DCP1A
Ensembl hg19 (Hinxton)ENSG00000272886 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000272886 [Gene_View]  ENSG00000272886 [Sequence]  chr3:53283425-53347627 [Contig_View]  DCP1A [Vega]
ICGC DataPortalENSG00000272886
TCGA cBioPortalDCP1A
AceView (NCBI)DCP1A
Genatlas (Paris)DCP1A
WikiGenes55802
SOURCE (Princeton)DCP1A
Genetics Home Reference (NIH)DCP1A
Genomic and cartography
GoldenPath hg38 (UCSC)DCP1A  -     chr3:53283425-53347627 -  3p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DCP1A  -     3p21.1   [Description]    (hg19-Feb_2009)
GoldenPathDCP1A - 3p21.1 [CytoView hg19]  DCP1A - 3p21.1 [CytoView hg38]
ImmunoBaseENSG00000272886
Mapping of homologs : NCBIDCP1A [Mapview hg19]  DCP1A [Mapview hg38]
OMIM607010   
Gene and transcription
Genbank (Entrez)AA129009 AB075507 AJ275986 AK001969 AK025344
RefSeq transcript (Entrez)NM_001290204 NM_001290205 NM_001290206 NM_001290207 NM_018403
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DCP1A
Cluster EST : UnigeneHs.476353 [ NCBI ]
CGAP (NCI)Hs.476353
Alternative Splicing GalleryENSG00000272886
Gene ExpressionDCP1A [ NCBI-GEO ]   DCP1A [ EBI - ARRAY_EXPRESS ]   DCP1A [ SEEK ]   DCP1A [ MEM ]
Gene Expression Viewer (FireBrowse)DCP1A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55802
GTEX Portal (Tissue expression)DCP1A
Human Protein AtlasENSG00000272886-DCP1A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NPI6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NPI6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NPI6
Splice isoforms : SwissVarQ9NPI6
PhosPhoSitePlusQ9NPI6
Domains : Interpro (EBI)Dcp1    mRNA_decap_C    PH-like_dom_sf   
Domain families : Pfam (Sanger)DCP1 (PF06058)    mRNA_decap_C (PF16741)   
Domain families : Pfam (NCBI)pfam06058    pfam16741   
Conserved Domain (NCBI)DCP1A
DMDM Disease mutations55802
Blocks (Seattle)DCP1A
PDB (RSDB)2WX3    4B6H   
PDB Europe2WX3    4B6H   
PDB (PDBSum)2WX3    4B6H   
PDB (IMB)2WX3    4B6H   
Structural Biology KnowledgeBase2WX3    4B6H   
SCOP (Structural Classification of Proteins)2WX3    4B6H   
CATH (Classification of proteins structures)2WX3    4B6H   
SuperfamilyQ9NPI6
Human Protein Atlas [tissue]ENSG00000272886-DCP1A [tissue]
Peptide AtlasQ9NPI6
HPRD06113
IPIIPI00164672   
Protein Interaction databases
DIP (DOE-UCLA)Q9NPI6
IntAct (EBI)Q9NPI6
FunCoupENSG00000272886
BioGRIDDCP1A
STRING (EMBL)DCP1A
ZODIACDCP1A
Ontologies - Pathways
QuickGOQ9NPI6
Ontology : AmiGOnuclear-transcribed mRNA catabolic process, nonsense-mediated decay  deadenylation-dependent decapping of nuclear-transcribed mRNA  P-body  P-body  protein binding  nucleus  cytoplasm  cytosol  enzyme activator activity  membrane  hydrolase activity  kinesin binding  deadenylation-independent decapping of nuclear-transcribed mRNA  cytoplasmic ribonucleoprotein granule  identical protein binding  positive regulation of catalytic activity  regulation of mRNA stability  exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay  protein localization to cytoplasmic stress granule  
Ontology : EGO-EBInuclear-transcribed mRNA catabolic process, nonsense-mediated decay  deadenylation-dependent decapping of nuclear-transcribed mRNA  P-body  P-body  protein binding  nucleus  cytoplasm  cytosol  enzyme activator activity  membrane  hydrolase activity  kinesin binding  deadenylation-independent decapping of nuclear-transcribed mRNA  cytoplasmic ribonucleoprotein granule  identical protein binding  positive regulation of catalytic activity  regulation of mRNA stability  exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay  protein localization to cytoplasmic stress granule  
Pathways : KEGGRNA degradation   
NDEx NetworkDCP1A
Atlas of Cancer Signalling NetworkDCP1A
Wikipedia pathwaysDCP1A
Orthology - Evolution
OrthoDB55802
GeneTree (enSembl)ENSG00000272886
Phylogenetic Trees/Animal Genes : TreeFamDCP1A
HOGENOMQ9NPI6
Homologs : HomoloGeneDCP1A
Homology/Alignments : Family Browser (UCSC)DCP1A
Gene fusions - Rearrangements
Fusion : QuiverDCP1A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDCP1A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DCP1A
dbVarDCP1A
ClinVarDCP1A
1000_GenomesDCP1A 
Exome Variant ServerDCP1A
ExAC (Exome Aggregation Consortium)ENSG00000272886
GNOMAD BrowserENSG00000272886
Varsome BrowserDCP1A
Genetic variants : HAPMAP55802
Genomic Variants (DGV)DCP1A [DGVbeta]
DECIPHERDCP1A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDCP1A 
Mutations
ICGC Data PortalDCP1A 
TCGA Data PortalDCP1A 
Broad Tumor PortalDCP1A
OASIS PortalDCP1A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDCP1A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDCP1A
Mutations and Diseases : HGMDDCP1A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DCP1A
DgiDB (Drug Gene Interaction Database)DCP1A
DoCM (Curated mutations)DCP1A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DCP1A (select a term)
intoGenDCP1A
Cancer3DDCP1A(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607010   
Orphanet
DisGeNETDCP1A
MedgenDCP1A
Genetic Testing Registry DCP1A
NextProtQ9NPI6 [Medical]
TSGene55802
GENETestsDCP1A
Target ValidationDCP1A
Huge Navigator DCP1A [HugePedia]
snp3D : Map Gene to Disease55802
BioCentury BCIQDCP1A
ClinGenDCP1A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55802
Chemical/Pharm GKB GenePA134931379
Clinical trialDCP1A
Miscellaneous
canSAR (ICR)DCP1A (select the gene name)
DataMed IndexDCP1A
Probes
Litterature
PubMed81 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDCP1A
EVEXDCP1A
GoPubMedDCP1A
iHOPDCP1A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:39:53 CET 2019
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