DCP1A (decapping mRNA 1A)

2014-08-01  

Identity

HGNC
DCP1A
LOCATION
3p21.1
LOCUSID
55802
ALIAS
HSA275986,Nbla00360,SMAD4IP1,SMIF
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55802
MIM: 607010
HGNC: 18714
Ensembl: ENSG00000272886

Variants:

dbSNP: 55802
ClinVar: 55802
TCGA: ENSG00000272886
COSMIC: DCP1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000272886ENST00000294241Q9NPI6
ENSG00000272886ENST00000559748A0A087WVE6
ENSG00000272886ENST00000560076A0A087WXD0
ENSG00000272886ENST00000560624A0A087WT55
ENSG00000272886ENST00000610213Q9NPI6

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Decapping complexKEGGhsa_M00395
Decapping complexKEGGM00395
Gene ExpressionREACTOMER-HSA-74160
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
mRNA decay by 5' to 3' exoribonucleaseREACTOMER-HSA-430039
Nonsense-Mediated Decay (NMD)REACTOMER-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)REACTOMER-HSA-975957
Regulation of mRNA stability by proteins that bind AU-rich elementsREACTOMER-HSA-450531
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNAREACTOMER-HSA-450385
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNAREACTOMER-HSA-450513

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
124177152002Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay.173
218598622011c-Jun N-terminal kinase phosphorylates DCP1a to control formation of P bodies.37
230850782012Structural basis of the PNRC2-mediated link between mrna surveillance and decapping.35
245101892014The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1.33
118365242002SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling.24
198122492009Dcp1-bodies in mouse oocytes.22
233009422013The P body protein Dcp1a is hyper-phosphorylated during mitosis.21
275784852016Genetic variants in the PIWI-piRNA pathway gene DCP1A predict melanoma disease-specific survival.9
185133892008New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.8
299643372018MALAT1 promotes the colorectal cancer malignancy by increasing DCP1A expression and miR203 downregulation.8

Citation

Dessen P

DCP1A (decapping mRNA 1A)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54250/dcp1a