DCT (dopachrome tautomerase)

2007-02-01  

Identity

HGNC
DCT
LOCATION
13q32.1
LOCUSID
1638
ALIAS
OCA8,TRP-2,TYRP2

Other Information

Locus ID:

NCBI: 1638
MIM: 191275
HGNC: 2709
Ensembl: ENSG00000080166

Variants:

dbSNP: 1638
ClinVar: 1638
TCGA: ENSG00000080166
COSMIC: DCT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000080166ENST00000377028P40126
ENSG00000080166ENST00000446125P40126
ENSG00000080166ENST00000483392A0A0A0MTD3

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Tyrosine metabolismKEGGko00350
MelanogenesisKEGGko04916
Tyrosine metabolismKEGGhsa00350
MelanogenesisKEGGhsa04916
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Melanin biosynthesisREACTOMER-HSA-5662702

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
205207072010HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase.66
202212482010Association of the OCA2 polymorphism His615Arg with melanin content in east Asian populations: further evidence of convergent evolution of skin pigmentation.36
198551292009Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers.34
289239272017MIF and D-DT are potential disease severity modifiers in male MS subjects.26
183126272008Complex signatures of selection for the melanogenic loci TYR, TYRP1 and DCT in humans.20
229882522012Negative regulation of AMP-activated protein kinase (AMPK) activity by macrophage migration inhibitory factor (MIF) family members in non-small cell lung carcinomas.18
125599592003OTX2 regulates expression of DOPAchrome tautomerase in human retinal pigment epithelium.11
168571832006Dopachrome tautomerase (Dct) regulates neural progenitor cell proliferation.11
182061232008TRP-2 specifically decreases WM35 cell sensitivity to oxidative stress.9
228988272012The changes of microRNA expression profiles and tyrosinase related proteins in MITF knocked down melanocytes.9

Citation

Dessen P

DCT (dopachrome tautomerase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43594/dct