DCX (doublecortin)

2007-02-01  

Identity

HGNC
LOCATION
Xq23
LOCUSID
ALIAS
DBCN,DC,LISX,SCLH,XLIS
FUSION GENES

Other Information

Locus ID:

NCBI: 1641
MIM: 300121
HGNC: 2714
Ensembl: ENSG00000077279

Variants:

dbSNP: 1641
ClinVar: 1641
TCGA: ENSG00000077279
COSMIC: DCX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000077279ENST00000356220A8K340
ENSG00000077279ENST00000358070O43602
ENSG00000077279ENST00000371993O43602
ENSG00000077279ENST00000468911E7EU50
ENSG00000077279ENST00000488120O43602
ENSG00000077279ENST00000496551O43602
ENSG00000077279ENST00000635795O43602
ENSG00000077279ENST00000636035A8K340
ENSG00000077279ENST00000636381A0A1B0GUE1
ENSG00000077279ENST00000637453A8K340
ENSG00000077279ENST00000637570A0A1B0GWD1

Expression (GTEx)

0
1
2
3

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
L1CAM interactionsREACTOMER-HSA-373760
Neurofascin interactionsREACTOMER-HSA-447043

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
197135292009MiR-128 up-regulation inhibits Reelin and DCX expression and reduces neuroblastoma cell motility and invasiveness.56
227273742012Doublecortin recognizes the 13-protofilament microtubule cooperatively and tracks microtubule ends.53
209748132010Template-free 13-protofilament microtubule-MAP assembly visualized at 8 A resolution.52
249457702014Off-target effect of doublecortin family shRNA on neuronal migration associated with endogenous microRNA dysregulation.41
252837772014Doublecortin recognizes the longitudinal curvature of the microtubule end and lattice.36
156634752005Neuronal precursor-specific activity of a human doublecortin regulatory sequence.26
171113592007Magnetic resonance imaging and histological studies of corpus callosal and hippocampal abnormalities linked to doublecortin deficiency.23
124276742002Selective expression of doublecortin and LIS1 in developing human cortex suggests unique modes of neuronal movement.21
287669052017Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers.20
192212932009NGF, DCX, and NSE upregulation correlates with severity and outcome of head trauma in children.19

Citation

Dessen P

DCX (doublecortin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45751/dcx