Identity
HGNC
LOCATION
Xq23
LOCUSID
ALIAS
DBCN,DC,LISX,SCLH,XLIS
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1641
MIM: 300121
HGNC: 2714
Ensembl: ENSG00000077279
Variants:
dbSNP: 1641
ClinVar: 1641
TCGA: ENSG00000077279
COSMIC: DCX
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Developmental Biology | REACTOME | R-HSA-1266738 |
| Axon guidance | REACTOME | R-HSA-422475 |
| L1CAM interactions | REACTOME | R-HSA-373760 |
| Neurofascin interactions | REACTOME | R-HSA-447043 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35213059 | 2022 | Novel lissencephaly-associated DCX variants in the C-terminal DCX domain affect microtubule binding and dynamics. | 4 |
| 35213059 | 2022 | Novel lissencephaly-associated DCX variants in the C-terminal DCX domain affect microtubule binding and dynamics. | 4 |
| 32050972 | 2020 | Doublecortin undergo nucleocytoplasmic transport via the RanGTPase signaling to promote glioma progression. | 7 |
| 32050972 | 2020 | Doublecortin undergo nucleocytoplasmic transport via the RanGTPase signaling to promote glioma progression. | 7 |
| 30443988 | 2019 | Circular RNA CCDC66 targets DCX to regulate cell proliferation and migration by sponging miR-488-3p in Hirschsprung's disease. | 16 |
| 30625347 | 2019 | Doublecortin X (DCX) serine 28 phosphorylation is a regulatory switch, modulating association of DCX with microtubules and actin filaments. | 4 |
| 30979500 | 2019 | Pathogenic E2K mutation of doublecortin X (DCX) alters microtubule stabilisation and actin filament association. | 0 |
| 30443988 | 2019 | Circular RNA CCDC66 targets DCX to regulate cell proliferation and migration by sponging miR-488-3p in Hirschsprung's disease. | 16 |
| 30625347 | 2019 | Doublecortin X (DCX) serine 28 phosphorylation is a regulatory switch, modulating association of DCX with microtubules and actin filaments. | 4 |
| 30979500 | 2019 | Pathogenic E2K mutation of doublecortin X (DCX) alters microtubule stabilisation and actin filament association. | 0 |
| 30291144 | 2018 | A dominant dendrite phenotype caused by the disease-associated G253D mutation in doublecortin (DCX) is not due to its endocytosis defect. | 3 |
| 30291144 | 2018 | A dominant dendrite phenotype caused by the disease-associated G253D mutation in doublecortin (DCX) is not due to its endocytosis defect. | 3 |
| 28701724 | 2017 | Dynamic microtubule association of Doublecortin X (DCX) is regulated by its C-terminus. | 8 |
| 28766905 | 2017 | Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers. | 60 |
| 28701724 | 2017 | Dynamic microtubule association of Doublecortin X (DCX) is regulated by its C-terminus. | 8 |
Citation
Dessen P
DCX (doublecortin)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45751/dcx
