Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DCXR (dicarbonyl and L-xylulose reductase)

Identity

Alias_namesdicarbonyl/L-xylulose reductase
Alias_symbol (synonym)KIDCR
DCR
SDR20C1
Other aliasHCR2
HCRII
P34H
PNTSU
XR
HGNC (Hugo) DCXR
LocusID (NCBI) 51181
Atlas_Id 49843
Location 17q25.3  [Link to chromosome band 17q25]
Location_base_pair Starts at 82035881 and ends at 82037697 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DCXR (17q25.3) / CALM1 (14q32.11)DCXR (17q25.3) / DCXR (17q25.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DCXR   18985
Cards
Entrez_Gene (NCBI)DCXR  51181  dicarbonyl and L-xylulose reductase
AliasesDCR; HCR2; HCRII; KIDCR; 
P34H; PNTSU; SDR20C1; XR
GeneCards (Weizmann)DCXR
Ensembl hg19 (Hinxton)ENSG00000169738 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000169738 [Gene_View]  ENSG00000169738 [Sequence]  chr17:82035881-82037697 [Contig_View]  DCXR [Vega]
ICGC DataPortalENSG00000169738
TCGA cBioPortalDCXR
AceView (NCBI)DCXR
Genatlas (Paris)DCXR
WikiGenes51181
SOURCE (Princeton)DCXR
Genetics Home Reference (NIH)DCXR
Genomic and cartography
GoldenPath hg38 (UCSC)DCXR  -     chr17:82035881-82037697 -  17q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DCXR  -     17q25.3   [Description]    (hg19-Feb_2009)
GoldenPathDCXR - 17q25.3 [CytoView hg19]  DCXR - 17q25.3 [CytoView hg38]
ImmunoBaseENSG00000169738
Mapping of homologs : NCBIDCXR [Mapview hg19]  DCXR [Mapview hg38]
OMIM260800   608347   
Gene and transcription
Genbank (Entrez)AA446582 AB013846 AF113123 AF139841 AF515623
RefSeq transcript (Entrez)NM_001195218 NM_016286
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DCXR
Cluster EST : UnigeneHs.9857 [ NCBI ]
CGAP (NCI)Hs.9857
Alternative Splicing GalleryENSG00000169738
Gene ExpressionDCXR [ NCBI-GEO ]   DCXR [ EBI - ARRAY_EXPRESS ]   DCXR [ SEEK ]   DCXR [ MEM ]
Gene Expression Viewer (FireBrowse)DCXR [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51181
GTEX Portal (Tissue expression)DCXR
Human Protein AtlasENSG00000169738-DCXR [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z4W1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z4W1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z4W1
Splice isoforms : SwissVarQ7Z4W1
Catalytic activity : Enzyme1.1.1.10 [ Enzyme-Expasy ]   1.1.1.101.1.1.10 [ IntEnz-EBI ]   1.1.1.10 [ BRENDA ]   1.1.1.10 [ KEGG ]   
PhosPhoSitePlusQ7Z4W1
Domaine pattern : Prosite (Expaxy)ADH_SHORT (PS00061)   
Domains : Interpro (EBI)NAD(P)-bd_dom_sf    Sc_DH/Rdtase_CS    SDR_fam   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)DCXR
DMDM Disease mutations51181
Blocks (Seattle)DCXR
PDB (RSDB)1PR9    1WNT    3D3W   
PDB Europe1PR9    1WNT    3D3W   
PDB (PDBSum)1PR9    1WNT    3D3W   
PDB (IMB)1PR9    1WNT    3D3W   
Structural Biology KnowledgeBase1PR9    1WNT    3D3W   
SCOP (Structural Classification of Proteins)1PR9    1WNT    3D3W   
CATH (Classification of proteins structures)1PR9    1WNT    3D3W   
SuperfamilyQ7Z4W1
Human Protein Atlas [tissue]ENSG00000169738-DCXR [tissue]
Peptide AtlasQ7Z4W1
HPRD16320
IPIIPI00448095   IPI00797249   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z4W1
IntAct (EBI)Q7Z4W1
FunCoupENSG00000169738
BioGRIDDCXR
STRING (EMBL)DCXR
ZODIACDCXR
Ontologies - Pathways
QuickGOQ7Z4W1
Ontology : AmiGOcarbonyl reductase (NADPH) activity  nucleus  cytoplasmic microtubule  plasma membrane  microvillus  brush border  xylulose metabolic process  xylulose metabolic process  glucose metabolic process  glucose metabolic process  NADP metabolic process  oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor  glucuronate catabolic process to xylulose 5-phosphate  D-xylose metabolic process  identical protein binding  L-xylulose reductase (NAD+) activity  L-xylulose reductase (NADP+) activity  L-xylulose reductase (NADP+) activity  protein homotetramerization  oxidation-reduction process  extracellular exosome  
Ontology : EGO-EBIcarbonyl reductase (NADPH) activity  nucleus  cytoplasmic microtubule  plasma membrane  microvillus  brush border  xylulose metabolic process  xylulose metabolic process  glucose metabolic process  glucose metabolic process  NADP metabolic process  oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor  glucuronate catabolic process to xylulose 5-phosphate  D-xylose metabolic process  identical protein binding  L-xylulose reductase (NAD+) activity  L-xylulose reductase (NADP+) activity  L-xylulose reductase (NADP+) activity  protein homotetramerization  oxidation-reduction process  extracellular exosome  
Pathways : KEGGPentose and glucuronate interconversions   
NDEx NetworkDCXR
Atlas of Cancer Signalling NetworkDCXR
Wikipedia pathwaysDCXR
Orthology - Evolution
OrthoDB51181
GeneTree (enSembl)ENSG00000169738
Phylogenetic Trees/Animal Genes : TreeFamDCXR
HOGENOMQ7Z4W1
Homologs : HomoloGeneDCXR
Homology/Alignments : Family Browser (UCSC)DCXR
Gene fusions - Rearrangements
Fusion : QuiverDCXR
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDCXR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DCXR
dbVarDCXR
ClinVarDCXR
1000_GenomesDCXR 
Exome Variant ServerDCXR
ExAC (Exome Aggregation Consortium)ENSG00000169738
GNOMAD BrowserENSG00000169738
Varsome BrowserDCXR
Genetic variants : HAPMAP51181
Genomic Variants (DGV)DCXR [DGVbeta]
DECIPHERDCXR [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDCXR 
Mutations
ICGC Data PortalDCXR 
TCGA Data PortalDCXR 
Broad Tumor PortalDCXR
OASIS PortalDCXR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDCXR  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDCXR
Mutations and Diseases : HGMDDCXR
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DCXR
DgiDB (Drug Gene Interaction Database)DCXR
DoCM (Curated mutations)DCXR (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DCXR (select a term)
intoGenDCXR
Cancer3DDCXR(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM260800    608347   
Orphanet3363   
DisGeNETDCXR
MedgenDCXR
Genetic Testing Registry DCXR
NextProtQ7Z4W1 [Medical]
TSGene51181
GENETestsDCXR
Target ValidationDCXR
Huge Navigator DCXR [HugePedia]
snp3D : Map Gene to Disease51181
BioCentury BCIQDCXR
ClinGenDCXR
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51181
Chemical/Pharm GKB GenePA38772
Clinical trialDCXR
Miscellaneous
canSAR (ICR)DCXR (select the gene name)
DataMed IndexDCXR
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDCXR
EVEXDCXR
GoPubMedDCXR
iHOPDCXR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:39:56 CET 2019
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