DCXR (dicarbonyl and L-xylulose reductase)

2007-12-01  

Identity

HGNC
DCXR
LOCATION
17q25.3
LOCUSID
51181
ALIAS
DCR,HCR2,HCRII,KIDCR,P34H,PNTSU,SDR20C1,XR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51181
MIM: 608347
HGNC: 18985
Ensembl: ENSG00000169738

Variants:

dbSNP: 51181
ClinVar: 51181
TCGA: ENSG00000169738
COSMIC: DCXR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169738ENST00000306869Q7Z4W1
ENSG00000169738ENST00000306869A0A384NY14
ENSG00000169738ENST00000577532J3QL34
ENSG00000169738ENST00000577712J3KSZ5
ENSG00000169738ENST00000579004J3QRQ2
ENSG00000169738ENST00000579155J3KRZ4
ENSG00000169738ENST00000579821J3QS45
ENSG00000169738ENST00000581584J3QS36
ENSG00000169738ENST00000582900J3KS22

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pentose and glucuronate interconversionsKEGGko00040
Pentose and glucuronate interconversionsKEGGhsa00040
Metabolic pathwaysKEGGhsa01100
Glucuronate pathway (uronate pathway)KEGGM00014
Glucuronate pathway (uronate pathway)KEGGhsa_M00014
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Catabolism of glucuronate to xylulose-5-phosphateREACTOMER-HSA-5661270

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
118826502002Molecular characterization of mammalian dicarbonyl/L-xylulose reductase and its localization in kidney.18
180867652007Dicarbonyl/L-xylulose reductase: a potential biomarker identified by laser-capture microdissection-micro serial analysis of gene expression of human prostate adenocarcinoma.6
159063192005Structure of the tetrameric form of human L-Xylulose reductase: probing the inhibitor-binding site with molecular modeling and site-directed mutagenesis.5
174344982007Epididymal P34H protein deficiency in men evaluated for infertility.5
168475672006Decreased expression of the human carbonyl reductase 2 gene HCR2 in hepatocellular carcinoma.4
175763322007Expression of dicarbonyl/L-xylulose reductase (DCXR) in human skin and melanocytic lesions: morphological studies supporting cell adhesion function of DCXR.4
180794832008Suppression of renal alpha-dicarbonyl compounds generated following ureteral obstruction by kidney-specific alpha-dicarbonyl/L-xylulose reductase.4
285950022017Diacetyl/l-Xylulose Reductase Mediates Chemical Redox Cycling in Lung Epithelial Cells.4
166167432006Levels of P34H, a sperm protein of epididymal origin, as a predictor of conventional in vitro fertilization outcome.3
220428732011Garrod's fourth inborn error of metabolism solved by the identification of mutations causing pentosuria.2

Citation

Dessen P

DCXR (dicarbonyl and L-xylulose reductase)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49843/dcxr