Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DDAH1 (dimethylarginine dimethylaminohydrolase 1)

Identity

Alias_symbol (synonym)DDAH
Other aliasDDAH-1
DDAHI
HEL-S-16
HGNC (Hugo) DDAH1
LocusID (NCBI) 23576
Atlas_Id 53958
Location 1p22.3  [Link to chromosome band 1p22]
Location_base_pair Starts at 85318485 and ends at 85465206 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BMPR1B (4q22.3) / DDAH1 (1p22.3)DDAH1 (1p22.3) / ZNHIT6 (1p22.3)RMND5A (2p11.2) / DDAH1 (1p22.3)
SLC24A3 (20p11.23) / DDAH1 (1p22.3)SRPK1 (6p21.31) / DDAH1 (1p22.3)BMPR1B 4q22.3 / DDAH1 1p22.3
DDAH1 1p22.3 / ZNHIT6 1p22.3SRPK1 6p21.31 / DDAH1 1p22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  DDAH1/ZNHIT6 (1p22)
t(1;4)(p22;q22) BMPR1B/DDAH1
t(1;6)(p22;p21) SRPK1/DDAH1

External links

Nomenclature
HGNC (Hugo)DDAH1   2715
Cards
Entrez_Gene (NCBI)DDAH1  23576  dimethylarginine dimethylaminohydrolase 1
AliasesDDAH; DDAH-1; DDAHI; HEL-S-16
GeneCards (Weizmann)DDAH1
Ensembl hg19 (Hinxton)ENSG00000153904 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000153904 [Gene_View]  ENSG00000153904 [Sequence]  chr1:85318485-85465206 [Contig_View]  DDAH1 [Vega]
ICGC DataPortalENSG00000153904
TCGA cBioPortalDDAH1
AceView (NCBI)DDAH1
Genatlas (Paris)DDAH1
WikiGenes23576
SOURCE (Princeton)DDAH1
Genetics Home Reference (NIH)DDAH1
Genomic and cartography
GoldenPath hg38 (UCSC)DDAH1  -     chr1:85318485-85465206 -  1p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DDAH1  -     1p22.3   [Description]    (hg19-Feb_2009)
GoldenPathDDAH1 - 1p22.3 [CytoView hg19]  DDAH1 - 1p22.3 [CytoView hg38]
ImmunoBaseENSG00000153904
Mapping of homologs : NCBIDDAH1 [Mapview hg19]  DDAH1 [Mapview hg38]
OMIM604743   
Gene and transcription
Genbank (Entrez)AK024917 AK026093 AK055626 AK098405 AK294752
RefSeq transcript (Entrez)NM_001134445 NM_001330655 NM_012137
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DDAH1
Cluster EST : UnigeneHs.713411 [ NCBI ]
CGAP (NCI)Hs.713411
Alternative Splicing GalleryENSG00000153904
Gene ExpressionDDAH1 [ NCBI-GEO ]   DDAH1 [ EBI - ARRAY_EXPRESS ]   DDAH1 [ SEEK ]   DDAH1 [ MEM ]
Gene Expression Viewer (FireBrowse)DDAH1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23576
GTEX Portal (Tissue expression)DDAH1
Human Protein AtlasENSG00000153904-DDAH1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO94760   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO94760  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO94760
Splice isoforms : SwissVarO94760
Catalytic activity : Enzyme3.5.3.18 [ Enzyme-Expasy ]   3.5.3.183.5.3.18 [ IntEnz-EBI ]   3.5.3.18 [ BRENDA ]   3.5.3.18 [ KEGG ]   
PhosPhoSitePlusO94760
Domains : Interpro (EBI)DDAH/AD    DDAH1   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)DDAH1
DMDM Disease mutations23576
Blocks (Seattle)DDAH1
PDB (RSDB)2JAI    2JAJ    3I2E    3I4A    3P8E    3P8P   
PDB Europe2JAI    2JAJ    3I2E    3I4A    3P8E    3P8P   
PDB (PDBSum)2JAI    2JAJ    3I2E    3I4A    3P8E    3P8P   
PDB (IMB)2JAI    2JAJ    3I2E    3I4A    3P8E    3P8P   
Structural Biology KnowledgeBase2JAI    2JAJ    3I2E    3I4A    3P8E    3P8P   
SCOP (Structural Classification of Proteins)2JAI    2JAJ    3I2E    3I4A    3P8E    3P8P   
CATH (Classification of proteins structures)2JAI    2JAJ    3I2E    3I4A    3P8E    3P8P   
SuperfamilyO94760
Human Protein Atlas [tissue]ENSG00000153904-DDAH1 [tissue]
Peptide AtlasO94760
HPRD09203
IPIIPI00220342   IPI01011679   IPI01015224   IPI00910124   
Protein Interaction databases
DIP (DOE-UCLA)O94760
IntAct (EBI)O94760
FunCoupENSG00000153904
BioGRIDDDAH1
STRING (EMBL)DDAH1
ZODIACDDAH1
Ontologies - Pathways
QuickGOO94760
Ontology : AmiGOcitrulline metabolic process  citrulline metabolic process  regulation of systemic arterial blood pressure  catalytic activity  cytosol  arginine metabolic process  arginine catabolic process  nitric oxide mediated signal transduction  negative regulation of cell proliferation  dimethylargininase activity  dimethylargininase activity  amino acid binding  negative regulation of vascular permeability  positive regulation of nitric oxide biosynthetic process  positive regulation of nitric oxide biosynthetic process  positive regulation of angiogenesis  metal ion binding  regulation of nitric-oxide synthase activity  extracellular exosome  negative regulation of cellular response to hypoxia  
Ontology : EGO-EBIcitrulline metabolic process  citrulline metabolic process  regulation of systemic arterial blood pressure  catalytic activity  cytosol  arginine metabolic process  arginine catabolic process  nitric oxide mediated signal transduction  negative regulation of cell proliferation  dimethylargininase activity  dimethylargininase activity  amino acid binding  negative regulation of vascular permeability  positive regulation of nitric oxide biosynthetic process  positive regulation of nitric oxide biosynthetic process  positive regulation of angiogenesis  metal ion binding  regulation of nitric-oxide synthase activity  extracellular exosome  negative regulation of cellular response to hypoxia  
NDEx NetworkDDAH1
Atlas of Cancer Signalling NetworkDDAH1
Wikipedia pathwaysDDAH1
Orthology - Evolution
OrthoDB23576
GeneTree (enSembl)ENSG00000153904
Phylogenetic Trees/Animal Genes : TreeFamDDAH1
HOGENOMO94760
Homologs : HomoloGeneDDAH1
Homology/Alignments : Family Browser (UCSC)DDAH1
Gene fusions - Rearrangements
Fusion : MitelmanBMPR1B/DDAH1 [4q22.3/1p22.3]  [t(1;4)(p22;q22)]  
Fusion : MitelmanDDAH1/ZNHIT6 [1p22.3/1p22.3]  [t(1;1)(p22;p22)]  
Fusion : MitelmanSRPK1/DDAH1 [6p21.31/1p22.3]  [t(1;6)(p22;p21)]  
Fusion PortalBMPR1B 4q22.3 DDAH1 1p22.3 KIRC
Fusion PortalDDAH1 1p22.3 ZNHIT6 1p22.3 BRCA
Fusion PortalSRPK1 6p21.31 DDAH1 1p22.3 BRCA
Fusion : QuiverDDAH1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDDAH1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DDAH1
dbVarDDAH1
ClinVarDDAH1
1000_GenomesDDAH1 
Exome Variant ServerDDAH1
ExAC (Exome Aggregation Consortium)ENSG00000153904
GNOMAD BrowserENSG00000153904
Varsome BrowserDDAH1
Genetic variants : HAPMAP23576
Genomic Variants (DGV)DDAH1 [DGVbeta]
DECIPHERDDAH1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDDAH1 
Mutations
ICGC Data PortalDDAH1 
TCGA Data PortalDDAH1 
Broad Tumor PortalDDAH1
OASIS PortalDDAH1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDDAH1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDDAH1
Mutations and Diseases : HGMDDDAH1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch DDAH1
DgiDB (Drug Gene Interaction Database)DDAH1
DoCM (Curated mutations)DDAH1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DDAH1 (select a term)
intoGenDDAH1
Cancer3DDDAH1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604743   
Orphanet
DisGeNETDDAH1
MedgenDDAH1
Genetic Testing Registry DDAH1
NextProtO94760 [Medical]
TSGene23576
GENETestsDDAH1
Target ValidationDDAH1
Huge Navigator DDAH1 [HugePedia]
snp3D : Map Gene to Disease23576
BioCentury BCIQDDAH1
ClinGenDDAH1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23576
Chemical/Pharm GKB GenePA27185
Clinical trialDDAH1
Miscellaneous
canSAR (ICR)DDAH1 (select the gene name)
DataMed IndexDDAH1
Probes
Litterature
PubMed88 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDDAH1
EVEXDDAH1
GoPubMedDDAH1
iHOPDDAH1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:39:57 CET 2019
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