DDX19B (DEAD-box helicase 19B)

2007-04-01  

Identity

HGNC
DDX19B
LOCATION
16q22.1
LOCUSID
11269
ALIAS
DBP5,DDX19,RNAh
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11269
MIM: 605812
HGNC: 2742
Ensembl: ENSG00000157349

Variants:

dbSNP: 11269
ClinVar: 11269
TCGA: ENSG00000157349
COSMIC: DDX19B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000157349ENST00000288071Q9UMR2
ENSG00000157349ENST00000288071A0A0U4B4U6
ENSG00000157349ENST00000355992Q9UMR2
ENSG00000157349ENST00000393657Q9UMR2
ENSG00000157349ENST00000393657A0A024QZ90
ENSG00000157349ENST00000451014Q9UMR2
ENSG00000157349ENST00000562519H3BPV3
ENSG00000157349ENST00000562912H3BUH0
ENSG00000157349ENST00000563206H3BQK0
ENSG00000157349ENST00000563392Q9UMR2
ENSG00000157349ENST00000563392A0A024QZ90
ENSG00000157349ENST00000566216H3BMQ5
ENSG00000157349ENST00000568008H3BMV7
ENSG00000157349ENST00000568408H3BTX1
ENSG00000157349ENST00000568460H3BUH0
ENSG00000157349ENST00000568625Q9UMR2
ENSG00000157349ENST00000568625A0A024QZ90

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
192190462009The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner.83
192442452009The DEXD/H-box RNA helicase DDX19 is regulated by an {alpha}-helical switch.56
220644662011Dbp5, Gle1-IP6 and Nup159: a working model for mRNP export.44
281803042017RNA helicase DDX19 stabilizes ribosomal elongation and termination complexes.10
255856912015RNA export factor Ddx19 is required for nuclear import of the SRF coactivator MKL1.9
297465422018Depletion of mRNA export regulator DBP5/DDX19, GLE1 or IPPK that is a key enzyme for the production of IP6, resulting in differentially altered cytoplasmic mRNA expression and specific cell defect.4
297828322018Nup159 Weakens Gle1 Binding to Dbp5 But Does Not Accelerate ADP Release.3
122199402002Identification and characterization of a gene coding a novel isoform of DEAD-box protein.0

Citation

Dessen P

DDX19B (DEAD-box helicase 19B)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46753/ddx19b