DDX3X (DEAD-box helicase 3 X-linked)

2007-02-01  

Identity

HGNC
LOCATION
Xp11.4
LOCUSID
ALIAS
CAP-Rf,DBX,DDX14,DDX3,HLP2,MRX102,MRXSSB
FUSION GENES

Other Information

Locus ID:

NCBI: 1654
MIM: 300160
HGNC: 2745
Ensembl: ENSG00000215301

Variants:

dbSNP: 1654
ClinVar: 1654
TCGA: ENSG00000215301
COSMIC: DDX3X

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000215301ENST00000399959A0A2U3TZJ9
ENSG00000215301ENST00000441189F6S8Q4
ENSG00000215301ENST00000457138O00571
ENSG00000215301ENST00000478993O00571
ENSG00000215301ENST00000542215A0A2R8Y4D2
ENSG00000215301ENST00000611968A0A087WVZ1
ENSG00000215301ENST00000615313A0A2R8YF89
ENSG00000215301ENST00000615742A0A087WX09
ENSG00000215301ENST00000616050A0A0J9YVQ7
ENSG00000215301ENST00000625837A0A0D9SF53
ENSG00000215301ENST00000626301A0A0D9SFB3
ENSG00000215301ENST00000629496O00571
ENSG00000215301ENST00000629785O00571
ENSG00000215301ENST00000630255O00571
ENSG00000215301ENST00000630370A0A0D9SG12
ENSG00000215301ENST00000630858A0A0D9SG12
ENSG00000215301ENST00000642322A0A2R8Y7T2
ENSG00000215301ENST00000642424A0A2R8Y7T2
ENSG00000215301ENST00000642793A0A2R8YCU0
ENSG00000215301ENST00000643821A0A2R8YF31
ENSG00000215301ENST00000643963A0A2R8Y650
ENSG00000215301ENST00000644073A0A2R8YCW1
ENSG00000215301ENST00000644074A0A2R8YFR4
ENSG00000215301ENST00000644109A0A2R8Y645
ENSG00000215301ENST00000644513A0A2R8Y4A4
ENSG00000215301ENST00000644677A0A2R8Y5G6
ENSG00000215301ENST00000644876O00571
ENSG00000215301ENST00000645080A0A2R8YF31
ENSG00000215301ENST00000645589A0A2R8YDH3
ENSG00000215301ENST00000645783A0A2R8YF31
ENSG00000215301ENST00000646107A0A2R8Y5G6
ENSG00000215301ENST00000646122A0A2R8YF78
ENSG00000215301ENST00000646223A0A2R8Y770
ENSG00000215301ENST00000646319A0A2R8YFS5
ENSG00000215301ENST00000646627A0A2R8Y7T2
ENSG00000215301ENST00000646679A0A2R8YDT5
ENSG00000215301ENST00000647373A0A2R8YGJ1

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Hepatitis BKEGGhsa05161
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
186360902008Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation.149
178555212007DDX3 DEAD-box RNA helicase is required for hepatitis C virus RNA replication.113
185839602008The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response.100
185962382008The DEAD-box RNA helicase DDX3 associates with export messenger ribonucleoproteins as well as tip-associated protein and participates in translational control.93
182641322008Oncogenic role of DDX3 in breast cancer biogenesis.91
228721502012DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs.88
261929172015Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma.88
168186302006DDX3, a DEAD box RNA helicase with tumor growth-suppressive property and transcriptional regulation activity of the p21waf1/cip1 promoter, is a candidate tumor suppressor.78
176679412008Candidate tumor suppressor DDX3 RNA helicase specifically represses cap-dependent translation by acting as an eIF4E inhibitory protein.75
206578222010Hepatitis B virus polymerase blocks pattern recognition receptor signaling via interaction with DDX3: implications for immune evasion.75

Citation

Dessen P

DDX3X (DEAD-box helicase 3 X-linked)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43986/ddx3x