DDX6 (DEAD-box helicase 6)

2003-02-01  

Identity

HGNC
LOCATION
11q23.3
LOCUSID
ALIAS
HLR2,IDDILF,P54,RCK,Rck/p54
FUSION GENES

Other Information

Locus ID:

NCBI: 1656
MIM: 600326
HGNC: 2747
Ensembl: ENSG00000110367

Variants:

dbSNP: 1656
ClinVar: 1656
TCGA: ENSG00000110367
COSMIC: DDX6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110367ENST00000526070P26196
ENSG00000110367ENST00000534980P26196
ENSG00000110367ENST00000617381Q8IV96
ENSG00000110367ENST00000620157P26196

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Decapping complexKEGGhsa_M00395
Decapping complexKEGGM00395
Gene ExpressionREACTOMER-HSA-74160
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
mRNA decay by 5' to 3' exoribonucleaseREACTOMER-HSA-430039

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
167563902006Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54.216
173925192007Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules.126
247685382014Structural and biochemical insights to the role of the CCR4-NOT complex and DDX6 ATPase in microRNA repression.106
247685402014A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing.105
219574972011Quantitative mass spectrometry of DENV-2 RNA-interacting proteins reveals that the DEAD-box RNA helicase DDX6 binds the DB1 and DB2 3' UTR structures.88
192859482009Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B.60
203928462010DDX6 (Rck/p54) is required for efficient hepatitis C virus replication but not for internal ribosome entry site-directed translation.59
192975242009Role of p54 RNA helicase activity and its C-terminal domain in translational repression, P-body localization and assembly.54
201583042010A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.52
250352962014Human DDX6 effects miRNA-mediated gene silencing via direct binding to CNOT1.49

Citation

Dessen P

DDX6 (DEAD-box helicase 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/65/ddx6