DEDD (death effector domain containing)

2017-04-01  

Identity

HGNC
LOCATION
1q23.3
LOCUSID
ALIAS
CASP8IP1,DEDD1,DEFT,FLDED1,KE05

Other Information

Locus ID:

NCBI: 9191
MIM: 606841
HGNC: 2755
Ensembl: ENSG00000158796

Variants:

dbSNP: 9191
ClinVar: 9191
TCGA: ENSG00000158796
COSMIC: DEDD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158796ENST00000368005B1AQP5
ENSG00000158796ENST00000368006O75618
ENSG00000158796ENST00000458050O75618
ENSG00000158796ENST00000464113V9GY27
ENSG00000158796ENST00000490843O75618
ENSG00000158796ENST00000545495O75618

Expression (GTEx)

0
10
20
30
40
50
60

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
227190722012DEDD interacts with PI3KC3 to activate autophagy and attenuate epithelial-mesenchymal transition in human breast cancer.59
125278982003DEDD and DEDD2 associate with caspase-8/10 and signal cell death.23
280009002017miR-24-3p regulates bladder cancer cell proliferation, migration, invasion and autophagy by targeting DEDD.20
299539652018MicroRNA-17 inhibition overcomes chemoresistance and suppresses epithelial-mesenchymal transition through a DEDD-dependent mechanism in gastric cancer.13
119654972002Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC.9
301756642018Long Noncoding RNA LINC00472 Inhibits Proliferation and Promotes Apoptosis of Lung Adenocarcinoma Cells via Regulating miR-24-3p/ DEDD.7
200701222010Localization of the death effector domain of Fas-associated death domain protein into the membrane of Escherichia coli induces reactive oxygen species-involved cell death.1
307778792019MCL1 and DEDD Promote Urothelial Carcinoma Progression.1

Citation

Dessen P

DEDD (death effector domain containing)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56750/dedd