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DENND6B (DENN domain containing 6B)

Identity

Alias (NCBI)AFI1B
FAM116B
HGNC (Hugo) DENND6B
HGNC Alias symbMGC33692
AFI1B
HGNC Previous nameFAM116B
HGNC Previous namefamily with sequence similarity 116, member B
 DENN/MADD domain containing 6B
LocusID (NCBI) 414918
Atlas_Id 62436
Location 22q13.33  [Link to chromosome band 22q13]
Location_base_pair Starts at 50311963 and ends at 50327060 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ZNF786 (7q36.1) / DENND6B (22q13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(7;22)(q36;q13) ZNF786/DENND6B

External links

Nomenclature
HGNC (Hugo)DENND6B   32690
Cards
Entrez_Gene (NCBI)DENND6B  414918  DENN domain containing 6B
AliasesAFI1B; FAM116B
GeneCards (Weizmann)DENND6B
Ensembl hg19 (Hinxton)ENSG00000205593 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000205593 [Gene_View]  ENSG00000205593 [Sequence]  chr22:50311963-50327060 [Contig_View]  DENND6B [Vega]
ICGC DataPortalENSG00000205593
TCGA cBioPortalDENND6B
AceView (NCBI)DENND6B
Genatlas (Paris)DENND6B
WikiGenes414918
SOURCE (Princeton)DENND6B
Genetics Home Reference (NIH)DENND6B
Genomic and cartography
GoldenPath hg38 (UCSC)DENND6B  -     chr22:50311963-50327060 -  22q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DENND6B  -     22q13.33   [Description]    (hg19-Feb_2009)
GoldenPathDENND6B - 22q13.33 [CytoView hg19]  DENND6B - 22q13.33 [CytoView hg38]
ImmunoBaseENSG00000205593
genome Data Viewer NCBIDENND6B [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AA864612 AK054743 BC031069 BI758775 BM981037
RefSeq transcript (Entrez)NM_001001794
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DENND6B
Alternative Splicing GalleryENSG00000205593
Gene ExpressionDENND6B [ NCBI-GEO ]   DENND6B [ EBI - ARRAY_EXPRESS ]   DENND6B [ SEEK ]   DENND6B [ MEM ]
Gene Expression Viewer (FireBrowse)DENND6B [ Firebrowse - Broad ]
GenevisibleExpression of DENND6B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)414918
GTEX Portal (Tissue expression)DENND6B
Human Protein AtlasENSG00000205593-DENND6B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NEG7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NEG7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NEG7
Splice isoforms : SwissVarQ8NEG7
PhosPhoSitePlusQ8NEG7
Domaine pattern : Prosite (Expaxy)DENN (PS50211)   
Domains : Interpro (EBI)ABL9/DENND6_dom    DENND6    Tripartite_DENN   
Domain families : Pfam (Sanger)Avl9 (PF09794)   
Domain families : Pfam (NCBI)pfam09794   
Conserved Domain (NCBI)DENND6B
DMDM Disease mutations414918
Blocks (Seattle)DENND6B
SuperfamilyQ8NEG7
Human Protein Atlas [tissue]ENSG00000205593-DENND6B [tissue]
Peptide AtlasQ8NEG7
HPRD17526
IPIIPI00386146   IPI00852621   
Protein Interaction databases
DIP (DOE-UCLA)Q8NEG7
IntAct (EBI)Q8NEG7
FunCoupENSG00000205593
BioGRIDDENND6B
STRING (EMBL)DENND6B
ZODIACDENND6B
Ontologies - Pathways
QuickGOQ8NEG7
Ontology : AmiGOcytosol  Rab guanyl-nucleotide exchange factor activity  Rab guanyl-nucleotide exchange factor activity  recycling endosome  
Ontology : EGO-EBIcytosol  Rab guanyl-nucleotide exchange factor activity  Rab guanyl-nucleotide exchange factor activity  recycling endosome  
NDEx NetworkDENND6B
Atlas of Cancer Signalling NetworkDENND6B
Wikipedia pathwaysDENND6B
Orthology - Evolution
OrthoDB414918
GeneTree (enSembl)ENSG00000205593
Phylogenetic Trees/Animal Genes : TreeFamDENND6B
HOGENOMQ8NEG7
Homologs : HomoloGeneDENND6B
Homology/Alignments : Family Browser (UCSC)DENND6B
Gene fusions - Rearrangements
Fusion : QuiverDENND6B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDENND6B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DENND6B
dbVarDENND6B
ClinVarDENND6B
1000_GenomesDENND6B 
Exome Variant ServerDENND6B
GNOMAD BrowserENSG00000205593
Varsome BrowserDENND6B
Genetic variants : HAPMAP414918
Genomic Variants (DGV)DENND6B [DGVbeta]
DECIPHERDENND6B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDENND6B 
Mutations
ICGC Data PortalDENND6B 
TCGA Data PortalDENND6B 
Broad Tumor PortalDENND6B
OASIS PortalDENND6B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDENND6B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDENND6B
Mutations and Diseases : HGMDDENND6B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DENND6B
DgiDB (Drug Gene Interaction Database)DENND6B
DoCM (Curated mutations)DENND6B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DENND6B (select a term)
intoGenDENND6B
Cancer3DDENND6B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETDENND6B
MedgenDENND6B
Genetic Testing Registry DENND6B
NextProtQ8NEG7 [Medical]
TSGene414918
GENETestsDENND6B
Target ValidationDENND6B
Huge Navigator DENND6B [HugePedia]
snp3D : Map Gene to Disease414918
BioCentury BCIQDENND6B
ClinGenDENND6B
Clinical trials, drugs, therapy
Protein Interactions : CTD414918
Pharm GKB GenePA144596432
Clinical trialDENND6B
Miscellaneous
canSAR (ICR)DENND6B (select the gene name)
HarmonizomeDENND6B
DataMed IndexDENND6B
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDENND6B
EVEXDENND6B
GoPubMedDENND6B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jul 16 15:53:16 CEST 2020
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