DEPDC1 (DEP domain containing 1)

2015-10-01  

Identity

HGNC
DEPDC1
LOCATION
1p31.3
LOCUSID
55635
ALIAS
DEP.8,DEPDC1-V2,DEPDC1A,SDP35

Other Information

Locus ID:

NCBI: 55635
MIM: 612002
HGNC: 22949
Ensembl: ENSG00000024526

Variants:

dbSNP: 55635
ClinVar: 55635
TCGA: ENSG00000024526
COSMIC: DEPDC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000024526ENST00000370966Q5TB30
ENSG00000024526ENST00000456315Q5TB30
ENSG00000024526ENST00000489862H0YES2
ENSG00000024526ENST00000525124E9PL61

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
205875132010Cell-permeable peptide DEPDC1-ZNF224 interferes with transcriptional repression and oncogenicity in bladder cancer cells.27
250647372014DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis.16
279841152017Epigenetic disruption of miR-130a promotes prostate cancer by targeting SEC23B and DEPDC1.16
256052012014DEP domain containing 1 is a novel diagnostic marker and prognostic predictor for hepatocellular carcinoma.14
259028352015DEPDC1 is a novel cell cycle related gene that regulates mitotic progression.14
269702792016Protocadherin 10 inhibits cell proliferation and induces apoptosis via regulation of DEP domain containing 1 in endometrial endometrioid carcinoma.10
286340772017DEPDC1 promotes cell proliferation and tumor growth via activation of E2F signaling in prostate cancer.10
236461392013Inhibition of DEPDC1A, a bad prognostic marker in multiple myeloma, delays growth and induces mature plasma cell markers in malignant plasma cells.9
286026272017Phosphorylation of DEPDC1 at Ser110 is required to maintain centrosome organization during mitosis.7

Citation

Dessen P

DEPDC1 (DEP domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2015-10-01

Online version: http://atlasgeneticsoncology.org/gene/55477/depdc1