Atlas of Genetics and Cytogenetics in Oncology and Haematology

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DERL2 (derlin 2)

Identity

Alias_namesDer1-like domain family, member 2
Alias_symbol (synonym)F-LAN-1
FLANa
F-LANa
CGI-101
derlin-2
Other aliasDERtrin-2
HGNC (Hugo) DERL2
LocusID (NCBI) 51009
Atlas_Id 40518
Location 17p13.2  [Link to chromosome band 17p13]
Location_base_pair Starts at 5471251 and ends at 5486230 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)DERL2   17943
Cards
Entrez_Gene (NCBI)DERL2  51009  derlin 2
AliasesCGI-101; DERtrin-2; F-LAN-1; F-LANa; 
FLANa; derlin-2
GeneCards (Weizmann)DERL2
Ensembl hg19 (Hinxton)ENSG00000072849 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000072849 [Gene_View]  ENSG00000072849 [Sequence]  chr17:5471251-5486230 [Contig_View]  DERL2 [Vega]
ICGC DataPortalENSG00000072849
TCGA cBioPortalDERL2
AceView (NCBI)DERL2
Genatlas (Paris)DERL2
WikiGenes51009
SOURCE (Princeton)DERL2
Genetics Home Reference (NIH)DERL2
Genomic and cartography
GoldenPath hg38 (UCSC)DERL2  -     chr17:5471251-5486230 -  17p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)DERL2  -     17p13.2   [Description]    (hg19-Feb_2009)
GoldenPathDERL2 - 17p13.2 [CytoView hg19]  DERL2 - 17p13.2 [CytoView hg38]
ImmunoBaseENSG00000072849
Mapping of homologs : NCBIDERL2 [Mapview hg19]  DERL2 [Mapview hg38]
OMIM610304   
Gene and transcription
Genbank (Entrez)AF132289 AF151859 AF208065 AF242523 AK024574
RefSeq transcript (Entrez)NM_001304777 NM_001304779 NM_016041
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)DERL2
Cluster EST : UnigeneHs.730726 [ NCBI ]
CGAP (NCI)Hs.730726
Alternative Splicing GalleryENSG00000072849
Gene ExpressionDERL2 [ NCBI-GEO ]   DERL2 [ EBI - ARRAY_EXPRESS ]   DERL2 [ SEEK ]   DERL2 [ MEM ]
Gene Expression Viewer (FireBrowse)DERL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51009
GTEX Portal (Tissue expression)DERL2
Human Protein AtlasENSG00000072849-DERL2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9GZP9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9GZP9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9GZP9
Splice isoforms : SwissVarQ9GZP9
PhosPhoSitePlusQ9GZP9
Domains : Interpro (EBI)DER1   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)DERL2
DMDM Disease mutations51009
Blocks (Seattle)DERL2
SuperfamilyQ9GZP9
Human Protein Atlas [tissue]ENSG00000072849-DERL2 [tissue]
Peptide AtlasQ9GZP9
HPRD16796
IPIIPI00304264   
Protein Interaction databases
DIP (DOE-UCLA)Q9GZP9
IntAct (EBI)Q9GZP9
FunCoupENSG00000072849
BioGRIDDERL2
STRING (EMBL)DERL2
ZODIACDERL2
Ontologies - Pathways
QuickGOQ9GZP9
Ontology : AmiGOHrd1p ubiquitin ligase ERAD-L complex  suckling behavior  protein binding  early endosome  late endosome  endoplasmic reticulum  signal recognition particle receptor complex  endoplasmic reticulum membrane  positive regulation of cell proliferation  membrane  integral component of endoplasmic reticulum membrane  integral component of endoplasmic reticulum membrane  positive regulation of cell growth  ubiquitin-dependent ERAD pathway  ubiquitin-dependent ERAD pathway  endoplasmic reticulum unfolded protein response  endoplasmic reticulum unfolded protein response  retrograde protein transport, ER to cytosol  endoplasmic reticulum quality control compartment  signal recognition particle  misfolded protein binding  negative regulation of retrograde protein transport, ER to cytosol  endoplasmic reticulum mannose trimming  ubiquitin-specific protease binding  
Ontology : EGO-EBIHrd1p ubiquitin ligase ERAD-L complex  suckling behavior  protein binding  early endosome  late endosome  endoplasmic reticulum  signal recognition particle receptor complex  endoplasmic reticulum membrane  positive regulation of cell proliferation  membrane  integral component of endoplasmic reticulum membrane  integral component of endoplasmic reticulum membrane  positive regulation of cell growth  ubiquitin-dependent ERAD pathway  ubiquitin-dependent ERAD pathway  endoplasmic reticulum unfolded protein response  endoplasmic reticulum unfolded protein response  retrograde protein transport, ER to cytosol  endoplasmic reticulum quality control compartment  signal recognition particle  misfolded protein binding  negative regulation of retrograde protein transport, ER to cytosol  endoplasmic reticulum mannose trimming  ubiquitin-specific protease binding  
Pathways : KEGGProtein processing in endoplasmic reticulum   
NDEx NetworkDERL2
Atlas of Cancer Signalling NetworkDERL2
Wikipedia pathwaysDERL2
Orthology - Evolution
OrthoDB51009
GeneTree (enSembl)ENSG00000072849
Phylogenetic Trees/Animal Genes : TreeFamDERL2
HOGENOMQ9GZP9
Homologs : HomoloGeneDERL2
Homology/Alignments : Family Browser (UCSC)DERL2
Gene fusions - Rearrangements
Fusion : QuiverDERL2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDERL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DERL2
dbVarDERL2
ClinVarDERL2
1000_GenomesDERL2 
Exome Variant ServerDERL2
ExAC (Exome Aggregation Consortium)ENSG00000072849
GNOMAD BrowserENSG00000072849
Varsome BrowserDERL2
Genetic variants : HAPMAP51009
Genomic Variants (DGV)DERL2 [DGVbeta]
DECIPHERDERL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisDERL2 
Mutations
ICGC Data PortalDERL2 
TCGA Data PortalDERL2 
Broad Tumor PortalDERL2
OASIS PortalDERL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDERL2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DDERL2
Mutations and Diseases : HGMDDERL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DERL2
DgiDB (Drug Gene Interaction Database)DERL2
DoCM (Curated mutations)DERL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DERL2 (select a term)
intoGenDERL2
Cancer3DDERL2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610304   
Orphanet
DisGeNETDERL2
MedgenDERL2
Genetic Testing Registry DERL2
NextProtQ9GZP9 [Medical]
TSGene51009
GENETestsDERL2
Target ValidationDERL2
Huge Navigator DERL2 [HugePedia]
snp3D : Map Gene to Disease51009
BioCentury BCIQDERL2
ClinGenDERL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51009
Chemical/Pharm GKB GenePA134896343
Clinical trialDERL2
Miscellaneous
canSAR (ICR)DERL2 (select the gene name)
DataMed IndexDERL2
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDERL2
EVEXDERL2
GoPubMedDERL2
iHOPDERL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Wed Nov 13 17:40:13 CET 2019
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