Identity
HGNC
LOCATION
1p36.22
LOCUSID
ALIAS
DFF-45,DFF1,ICAD
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1676
MIM: 601882
HGNC: 2772
Ensembl: ENSG00000160049
Variants:
dbSNP: 1676
ClinVar: 1676
TCGA: ENSG00000160049
COSMIC: DFFA
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000160049 | ENST00000377036 | O00273 |
| ENSG00000160049 | ENST00000377036 | A0A024R4H5 |
| ENSG00000160049 | ENST00000377038 | O00273 |
| ENSG00000160049 | ENST00000476658 | K7ERT1 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 28914671 | 2018 | Endometrial Polyps and Benign Endometrial Hyperplasia Have Increased Prevalence of DNA Fragmentation Factors 40 and 45 (DFF40 and DFF45) Together With the Antiapoptotic B-Cell Lymphoma (Bcl-2) Protein Compared With Normal Human Endometria. | 2 |
| 28914671 | 2018 | Endometrial Polyps and Benign Endometrial Hyperplasia Have Increased Prevalence of DNA Fragmentation Factors 40 and 45 (DFF40 and DFF45) Together With the Antiapoptotic B-Cell Lymphoma (Bcl-2) Protein Compared With Normal Human Endometria. | 2 |
| 29091952 | 2017 | Evaluation of miRNA-196a2 and apoptosis-related target genes: ANXA1, DFFA and PDCD4 expression in gastrointestinal cancer patients: A pilot study. | 20 |
| 29091952 | 2017 | Evaluation of miRNA-196a2 and apoptosis-related target genes: ANXA1, DFFA and PDCD4 expression in gastrointestinal cancer patients: A pilot study. | 20 |
| 26106156 | 2015 | Engineered cellular gene-replacement platform for selective and inducible proteolytic profiling. | 3 |
| 26106156 | 2015 | Engineered cellular gene-replacement platform for selective and inducible proteolytic profiling. | 3 |
| 23451280 | 2013 | ICAD deficiency in human colon cancer and predisposition to colon tumorigenesis: linkage to apoptosis resistance and genomic instability. | 9 |
| 24277473 | 2013 | siRNA-mediated knock-down of DFF45 amplifies doxorubicin therapeutic effects in breast cancer cells. | 2 |
| 23451280 | 2013 | ICAD deficiency in human colon cancer and predisposition to colon tumorigenesis: linkage to apoptosis resistance and genomic instability. | 9 |
| 24277473 | 2013 | siRNA-mediated knock-down of DFF45 amplifies doxorubicin therapeutic effects in breast cancer cells. | 2 |
| 22378161 | 2012 | DFF45 expression in human endometrium is associated with menstrual cycle phases and decreases after menopause. | 2 |
| 22454513 | 2012 | Loss of Pnn expression results in mouse early embryonic lethality and cellular apoptosis through SRSF1-mediated alternative expression of Bcl-xS and ICAD. | 23 |
| 22378161 | 2012 | DFF45 expression in human endometrium is associated with menstrual cycle phases and decreases after menopause. | 2 |
| 22454513 | 2012 | Loss of Pnn expression results in mouse early embryonic lethality and cellular apoptosis through SRSF1-mediated alternative expression of Bcl-xS and ICAD. | 23 |
| 19882353 | 2010 | Histone H1 subtype preferences of DFF40 and possible nuclear localization of DFF40/45 in normal and trichostatin A-treated NB4 leukemic cells. | 4 |
Citation
Dessen P
DFFA (DNA fragmentation factor subunit alpha)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/40297/dffa
