DGAT1 (diacylglycerol O-acyltransferase 1)

2018-07-01  

Identity

HGNC
DGAT1
LOCATION
8q24.3
LOCUSID
8694
ALIAS
ARAT,ARGP1,DGAT,DIAR7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8694
MIM: 604900
HGNC: 2843
Ensembl: ENSG00000185000

Variants:

dbSNP: 8694
ClinVar: 8694
TCGA: ENSG00000185000
COSMIC: DGAT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185000ENST00000332324A0A0A0MR74
ENSG00000185000ENST00000528718O75907

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycerolipid metabolismKEGGko00561
Retinol metabolismKEGGko00830
Glycerolipid metabolismKEGGhsa00561
Retinol metabolismKEGGhsa00830
Metabolic pathwaysKEGGhsa01100
Fat digestion and absorptionKEGGko04975
Fat digestion and absorptionKEGGhsa04975
Triacylglycerol biosynthesisKEGGhsa_M00089
Triacylglycerol biosynthesisKEGGM00089
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Triglyceride BiosynthesisREACTOMER-HSA-75109
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Acyl chain remodeling of DAG and TAGREACTOMER-HSA-1482883
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
187578362008Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis.284
209356282010Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1.131
168942402006The lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: effects of obesity, insulin resistance, and TZD treatment.56
219903512011Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases.52
152581942004Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells.44
231145942012DGAT1 mutation is linked to a congenital diarrheal disorder.43
234208472013Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core.43
124017092002Dissociation of obesity and impaired glucose disposal in mice overexpressing acyl coenzyme a:diacylglycerol acyltransferase 1 in white adipose tissue.41
287681782017Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis.38
187684812008Acylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorption.36

Citation

Dessen P

DGAT1 (diacylglycerol O-acyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57559/dgat1